Review
Food Science & Technology
Jasmin Katrin Badawi
Summary: Prostate cancer is one of the most common cancers in men, with challenges in disease progression and resistance of cancer cells to available therapeutic agents. Further therapeutic agents are needed, and bee venom components have shown promising anticancer effects, particularly melittin.
Review
Food Science & Technology
Na-Yoen Kwon, Soo-Hyun Sung, Hyun-Kyung Sung, Jang-Kyung Park
Summary: Bee venom and its components have been found to have anticancer effects on breast cancer cells by reducing cell numbers and improving survival rates. The various mechanisms of action suggest the potential for reducing side effects and the future prevention and treatment of breast cancer.
Review
Oncology
Agata Malek, Maciej Strzemski, Joanna Kurzepa, Jacek Kurzepa
Summary: This paper presents the current state of knowledge regarding the mechanisms of anticancer activity of bee venom, showing its strong potential in inducing apoptosis and inhibiting the cell cycle of tumor cells without affecting normal cells significantly. Animal studies also support the safety of venom doses effective in vitro. This information is valuable for planning future clinical trials.
Article
Neurosciences
Agata Malek, Joanna Kocot, Kamila Mitrowska, Andrzej Posyniak, Jacek Kurzepa
Summary: This study evaluated the anticancer potential of honey bee venom on glioblastoma cells and found that it exhibited cytotoxic effects on the cells and inhibited the secretion of MMP-2 and MMP-9.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Food Science & Technology
Seongjae Bae, Hyemin Gu, Mi-Gyeong Gwon, Hyun-Jin An, Sang-Mi Han, Sun-Jae Lee, Jaechan Leem, Kwan-Kyu Park
Summary: Bee venom and melittin can alleviate skin infections caused by Streptococcus pyogenes and have anti-inflammatory effects.
Review
Nutrition & Dietetics
Pratibha Pandey, Fahad Khan, Minhaj Ahmad Khan, Rajnish Kumar, Tarun Kumar Upadhyay
Summary: Apitherapy using bee products, especially honeybee venom, has gained recognition globally in cancer therapeutics. Bee products, including honeybee venom, have shown significant potential in strengthening the immune system and improving human health.
Article
Biology
Ivan Koludarov, Mariana Velasque, Tobias Senoner, Thomas Timm, Carola Greve, Alexander Ben Hamadou, Deepak Kumar Gupta, Guenter Lochnit, Michael Heinzinger, Andreas Vilcinskas, Rosalyn Gloag, Brock A. Harpur, Lars Podsiadlowski, Burkhard Rost, Timothy N. W. Jackson, Sebastien Dutertre, Eckart Stolle, Bjoern M. von Reumont
Summary: Most venom genes in Hymenoptera are shared by all members of the clade, with single gene co-option being the primary source and gene duplication contributing to diversification. Only a few venom proteins, such as melittin and anthophilin1, appear to be unique to the bee lineage, suggesting that most venom proteins predate the evolution of the aculeate stinger and the mega-radiation of hymenopterans.
Article
Multidisciplinary Sciences
Naiqi Shi, Tibor G. Szanto, Jia He, Christina I. Schroeder, Andrew A. Walker, Jennifer R. Deuis, Irina Vetter, Gyoergy Panyi, Glenn F. King, Samuel D. Robinson
Summary: Most bee species have the ability to sting humans, causing painful reactions. This study investigates the venom composition of the Australian great carpenter bee and finds that it is similar to the venoms of other social bee species. The venom can directly activate mammalian sensory neurons and induce pain behaviors.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Asli Elif Tanugur-Samanc, Meral Kekecoglu
Summary: This research paper aimed to determine the characteristics of Anatolian bee venom through analyzing its chemical content and microbiological properties. The results showed that Anatolian bee venom has a high phospholipase A2 content, similar levels of apamin compared to other countries, and melittin content within standard values. The bee venom samples exhibited high sugar content and minimal microbial development, with no Staphylococcus aureus detected.
Article
Food Science & Technology
Karolina Bodlakova, Jan Cerny, Helena Sterbova, Roman Guran, Ondrej Zitka, Dalibor Kodrik
Summary: This study investigated the physiological responses of American cockroaches to honeybee venom. The results showed that bee venom caused severe stress and destruction of muscle cell ultrastructure in the cockroaches. The venom also regulated the levels of substances in the cockroaches' haemolymph and the activity of digestive enzymes. Furthermore, it significantly reduced vitellogenin levels in female cockroaches and had an impact on dopamine and glutathione levels.
Review
Pharmacology & Pharmacy
Peiying Shi, Shihui Xie, Jiali Yang, Yi Zhang, Shuo Han, Songkun Su, Hong Yao
Summary: This study reviewed the recent progress in the pharmacological effects and mechanisms of bee venom (BV) and its main components against various diseases. It identified the target proteins and signaling pathways involved, and bioinformatically predicted the potential effects and mechanisms on diseases. The review provides new insights into the therapeutic effects of BV and its main components.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ghada H. Mansour, Mohammed A. El-Magd, Dalia H. Mahfouz, Ismail A. Abdelhamid, Magda F. Mohamed, Nada S. Ibrahim, Abdel Hady A. Abdel Wahab, Emad M. Elzayat
Summary: The study found that Bee Venom and its active component, Melittin, when combined with Sorafenib, have a synergistic anticancer effect on HepG2 cells, potentially representing a new enhancing strategy for HCC treatment.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hafsa Er-Rouassi, Meryem Bakour, Soumaya Touzani, Miguel Vilas-Boas, Soraia Falcao, Catherine Vidal, Badiaa Lyoussi
Summary: This study evaluated the potential effect of bee venom and its major components on a mouse model of peripheral nerve injury. The results showed that bee venom treatment was more effective for behavioral recovery. After 4 weeks, the facial motoneurons in the BV-treated group showed normal labeling, while no such restoration was observed in the other groups.
Article
Biochemistry & Molecular Biology
Irina Tanuwidjaja, Lidija Svecnjak, Domenika Gugic, Marko Levanic, Slaven Juric, Marko Vincekovic, Mirna Mrkonjic Fuka
Summary: The study found that honey bee venom exhibited high antibacterial activity against a broad spectrum of potentially pathogenic bacteria, with efficiency comparable to conventional antibiotics in certain cases. This suggests the therapeutic potential of honey bee venom as an alternative antimicrobial compound in combating antibiotic resistance.
Article
Agriculture, Dairy & Animal Science
Alaa Elkomy, Ali El-Hanoun, Mohamed Abdella, Karim El-Sabrout
Summary: The study demonstrated that the use of bee venom (BV) in rabbit does positively impacted reproductive performance, immune response, and health status. It led to improvements in litter size, weight, survival rate, milk yield, hormone levels, conception and fertility rates, as well as reduction in liver enzyme activities. BV also increased total antioxidant capacity and levels of antioxidative enzymes and immunoglobulins while decreasing oxidative stress markers. The results suggest that BV can be an effective and safe alternative for enhancing reproductive traits, immune response, and health in rabbit farming.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Seung-Hak Cho, Jun-young Park, Cheorl-Ho Kim
Summary: Microorganisms and host cells have carbohydrate chains and lectins that can recognize each other, playing a critical role in defense mechanisms and pathogen infection. This review aims to identify the role of host glycans in the immune response against pathogenic intestinal bacteria through studies on the lectin-glycan interaction, providing a new perspective for the prevention and treatment of infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mi-Jin Choi, Yeo Reum Kim, Nam Gyu Park, Cheorl-Ho Kim, Young Dae Oh, Han Kyu Lim, Jong-Myoung Kim
Summary: This study identified a gene that influences the growth of Pacific abalone and found that it plays an important role in the host defense mechanism. The protein encoded by this gene was also found to exhibit antimicrobial activity against various bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yoonsung Lee, Young-Seuk Bae
Summary: This study demonstrates that the KCNQ1OT1-miR-760-CK2α pathway plays essential roles in senescence and calorie restriction (CR), suggesting KCNQ1OT1 as a novel therapeutic target for anti-aging and CR treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fukushi Abekura, Junyoung Park, Hakseong Lim, Hee-Do Kim, Hyunju Choi, Moon-Jo Lee, Cheorl-Ho Kim
Summary: The study demonstrates that LprG can suppress lipopolysaccharide-induced inflammation by downregulating the expression of related proteins and cytokines. These findings are of great significance for the development of anti-inflammatory medications and the utilization of Mycobacterium tuberculosis as a medical resource.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Jennifer K. Lee, Inyong Kim, Eun-Kyeong Jeon, Jung-Heun Ha, Cher-Won Hwang, Jin-Chul Kim, Woong-Suk Yang, Hyunju Choi, Hee-Do Kim, Cheorl-Ho Kim
Summary: Oat is a widely consumed cereal grain with high nutritional value and potential health benefits. Microbial fermentation enhances the quality and content of functional ingredients in oats, providing natural dietary supplements, antioxidants, and antiaging agents.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Yu-Chan Chang, Cheorl-Ho Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Abekura Fukushi, Hee-Do Kim, Yu-Chan Chang, Cheorl-Ho Kim
Summary: Aerobic glycolysis is a characteristic of many human cancers, playing a crucial role in the growth, invasion, immune escape, and drug resistance of cancer cells. The glycolysis pathway consists of multiple enzymatic reactions, with increased levels of glycolytic proteins and enzymatic activities observed in cancer cells. In the Warburg effect, cancer cells rely on glycolysis to generate energy instead of oxidative phosphorylation. The understanding of the Warburg effect can lead to the development of targeted therapies for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jun-Young Park, Cheorl-Ho Kim, Seung-Hak Cho
Summary: In this study, we developed a FimH inhibitor to prevent adhesion of enterohemorrhagic Escherichia coli on human intestinal epithelium during the early stage of infection. By investigating the ligand binding domain of FimH and analyzing its evolutionary characteristics, we identified a potential drug target and found that glycan-like peptides can serve as initial infection inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hee-Do Kim, Hyunju Choi, Fukushi Abekura, Jun-Young Park, Woong-Suk Yang, Seung-Hoon Yang, Cheorl-Ho Kim
Summary: There are three major assaying methods used to validate in vitro whitening activity from natural products: methods using mushroom tyrosinase, human tyrosinase, and dopachrome tautomerase (or tyrosinase-related protein-2, TRP-2). Whitening agent development consists of two ways, melanin synthesis inhibition in melanocytes and downregulation of melanocyte stimulation. Many researchers have recently presented the bioactivity-guided fractionation, discovery, purification, and identification of whitening agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyunju Choi, Hee-Do Kim, Yeon-Woo Choi, Hakseong Lim, Kyung-Woon Kim, Kyoung-Sook Kim, Young-Choon Lee, Cheorl-Ho Kim
Summary: This study isolated the GM3-interacting protein NOLC1 using the T7 phage display method, further elucidating the functional roles of GM3 and providing evidence for the association between GM3 and NOLC1.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
So-Young An, Ji-Won Lee, Hee-Do Kim, Kyoung-Sook Kim, Jong-Hyun Cho, Cheorl-Ho Kim, Young-Choon Lee
Summary: In this study, it was observed that human glioblastoma cells particularly expressed the hST8Sia V gene. The study found that the JNK/AP-1 signaling pathway controls the specific expression of the hST8Sia V gene in U87MG cells.
GLYCOCONJUGATE JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Hee-Do Kim, Hyunju Choi, Fukushi Abekura, Junyoung Park, Seung-Hak Cho, Young-Choon Lee, Cheorl-Ho Kim
Summary: This study investigates the immunomodulatory effect of MPT32 in murine macrophage cells, demonstrating the possibility of using it as a TB vaccine and drug candidate for TB prevention.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Jeong-Han Kang, Patrick Splinter, Christy Trussoni, Nicholas E. Pirius, Maria Eugenia Guicciardi, Anuradha Krishnan, Begum Ozturk, Gregory J. Gores, Nicholas F. LaRusso, Steven P. O'Hara
Article
Biochemistry & Molecular Biology
Jeong-Woo Park, Jihyeon Jeong, Young-Seuk Bae
Summary: Calorie restriction (CR) and autophagy activation have been found to extend the healthspan of organisms by delaying age-related diseases. This study investigated the role of protein kinase CK2 in CR and autophagy and found that CK2's expression was upregulated by CR, leading to the activation of SIRT1 and AMP-activated protein kinase (AMPK). Overexpression of CK2 alpha stimulated autophagy initiation and nucleation markers, and several molecules including SIRT1, AKT, mTOR, AMPK, and FoxO3a were involved in CK2-mediated autophagy. The findings suggest that inhibiting certain microRNAs or using their antisense inhibitors could mimic the effects of CR or induce autophagy.
MOLECULES AND CELLS
(2022)
Article
Biochemistry & Molecular Biology
Jeong-Woo Park, Young-Seuk Bae
Summary: This study investigated the roles of histone lysine demethylases JMJD2a and LSD1 in CK2 downregulation-mediated senescence. The results showed that CK2 downregulation reduced the expression of JMJD2a and LSD1 by activating mTOR, resulting in H3K9me3 induction. This study suggests that CK2 is a potential therapeutic target for age-related diseases.
