Review
Biochemistry & Molecular Biology
Hosna Mohammad Sadeghi, Ida Adeli, Daniela Calina, Anca Oana Docea, Taraneh Mousavi, Marzieh Daniali, Shekoufeh Nikfar, Aristidis Tsatsakis, Mohammad Abdollahi
Summary: PCOS is an endocrine-gynecology disorder affecting women of childbearing age, with incomplete understanding of its etiology and pathophysiology. Lifestyle modifications and alternative medicines are the preferred first-line therapy, and certain medications have shown potential for repurposing in PCOS. Further research and well-designed clinical trials are needed, as the current evidence is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Kexin Wang, Yanhua Li
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. The etiologies of this syndrome are complex and involve prenatal factors, genetic variation, epigenetic mechanisms, unhealthy lifestyles, and environmental toxins. This review examines the molecular mechanisms underlying PCOS pathogenesis at the level of signaling pathways and discusses potential therapies including exosome therapy, gene therapy, and drugs based on traditional Chinese medicine and natural compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Si-wei Zhang, Jing Zhou, Hans-Jurgen Gober, Wing Ting Leung, Ling Wang
Summary: PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Jin Yu, Yulai Zhou, Jie Ding, Danying Zhang, Chaoqin Yu, Hefeng Huang
Summary: This study aimed to investigate the metabolic characteristics of overweight women with PCOS and analyze the possible mechanisms. The results showed that overweight PCOS patients were prone to hypertension, diabetes, low gonadal levels, and insulin resistance. Inflammatory cytokines CXCL12/SDF-1, Serpin E1/PAI-1, and MIF were predicted to play a crucial role in inducing insulin resistance in overweight PCOS through various biological functions and signal transductions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Manuel R. Garcia-Saenz, Miry Lobaton-Ginsberg, Claudia Ramirez-Renteria, Nitzia Lopez-Juarez, Renata Saucedo, Jorge Valencia-Ortega, Aldo Ferreira-Hermosillo
Summary: This study evaluated the clinical and biochemical characteristics of patients with type 1 diabetes (T1D) with and without polycystic ovarian syndrome (PCOS). The results showed a prevalence of 39% for PCOS in T1D patients, and significant differences were found between patients with and without PCOS in terms of insulin usage, glucose levels, ovarian volume, and Ferriman-Gallwey scores. Additionally, PCOS women had a higher incidence of insulin resistance and metabolic syndrome.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Chunzhu Li, Chuan Xing, Jiaqi Zhang, Han Zhao, Wenjing Shi, Bing He
Summary: The research showed that time-restricted feeding can help women with anovulatory PCOS to lose weight, reduce body fat, improve menstrual irregularity, hyperandrogenemia, insulin resistance, and chronic inflammation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Lucas Bandeira Marchesan, Ramon Bossardi Ramos, Poli Mara Spritzer
Summary: The metabolic profiles of women with PCOS in Latin America are worse than those without PCOS in the same region, with higher anthropometric and metabolic parameters. Further studies evaluating metabolic comorbidities and distinct PCOS phenotypes in different Latin American countries are needed for primary and secondary prevention of PCOS in the region.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Jiayue Liu, Ying Liu, Xiaoliang Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, characterized by ovulation disorders, high androgen levels, and insulin resistance. The pathogenesis of PCOS is still unclear. Intestinal flora, known as the second genome of human beings, is closely linked to metabolic diseases, immune diseases, and infectious diseases. There is increasing evidence that intestinal flora can regulate insulin synthesis and secretion, affect androgen metabolism and follicular development, and play a role in chronic inflammation and obesity. The imbalance of intestinal flora, related to changes in microbial diversity and interactions with host cells, is associated with the occurrence and development of PCOS. Modulating intestinal flora may offer a potential direction for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Plant Sciences
Meng-fan Peng, Shuo Tian, Ya-gang Song, Cai-xia Li, Ming-san Miao, Zhen Ren, Ming Li
Summary: This study aimed to investigate the mechanism of TFEL intervention in a rat model of PCOS-IR, finding that TFEL can inhibit ovarian hyperplasia, regulate disorders of glucose and lipid metabolism, and improve the secretion of sex hormones by regulating the expression of signaling pathway-related proteins in the ovary and HPO axis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nazia Begum, Kandavalli Manipriya, B. Veeresh
Summary: This study developed a new animal model by combining a high-fat diet with letrozole to better simulate polycystic ovary syndrome (PCOS). Compared to the letrozole-only model, this new model can better demonstrate metabolic anomalies observed in PCOS.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Medical Laboratory Technology
Huiqing Liu, Xingqi Meng, Jinyuan Wang, Yi Wei, Jinru Tang, Xiaocan Lei, Weiguo He, Suyun Li
Summary: PCOS is an endocrinemetabolic disease affecting reproductive aged women, potentially leading to various complications. Recent studies have identified a protein called SAA that may be associated with PCOS, serving as a potential inflammatory biomarker.
CLINICA CHIMICA ACTA
(2021)
Review
Endocrinology & Metabolism
Yong Chen, Qian Zhang, Jinhui Ma, Yuexin Yu
Summary: This article uses bibliometric analysis to study the publication trends and research hotspots of insulin resistance in polycystic ovary syndrome (PCOS). By analyzing the basic information of the literature and categorizing the keywords, it provides a deep perspective and valuable information for research in this field.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Ling Zhu, Lidan Wang
Summary: This retrospective case-control study investigated the relationship between asprosin and insulin resistance in PCOS patients. The study found that PCOS patients had significantly higher levels of asprosin and insulin resistance compared to the control group. Asprosin was independently correlated with insulin resistance and CRP. Asprosin may be a new indicator for evaluating insulin resistance in PCOS patients.
Article
Obstetrics & Gynecology
Nefise Nazli Yenigul, Runa Ozelc, Emre Baser, Serdar Dilbaz, Oya Aldemir, Berna Dilbaz, Ozlem Moraloglu Tekin
Summary: The study compared the success rates of two controlled ovarian hyperstimulation protocols in women under 35 with diminished ovarian reserve. The results showed that there were no significant differences in clinical pregnancy rate, implantation rate, miscarriage rate, and live birth rate between the two groups.
GINEKOLOGIA POLSKA
(2022)
Article
Pediatrics
Gamze Yurtdas, Gamze Akbulut, Masallah Baran, Canan Yilmaz
Summary: In this study, the effects of Mediterranean diet (MD) and low-fat diet (LFD) on adolescents with obesity and NAFLD were compared. Both diets were found to reduce hepatic steatosis, inflammation, and oxidative stress, with MD showing greater improvement in some parameters like AST levels and antioxidant capacity. Overall, both diets had positive effects on reducing BMI, fat mass, hepatic steatosis, insulin resistance, and improving liver enzyme levels.
Article
Obstetrics & Gynecology
Nefise Nazli Yenigul, Serdar Dilbaz, Runa Ozelci, Oya Aldemir, Emre Baser, Iskender Kaplanoglu, Berna Dilbaz, Ozlem Moraloglu Tekin
Summary: A scoring system incorporating all ideal factors for embryo transfer was created and correlated with B-HCG results. Factors such as antral follicle count, endometrial thickness, and mature oocyte number were significantly higher in B-HCG positive patients. The scoring system demonstrated a cutoff value of 9.5 for predicting B-HCG positivity, with 82% sensitivity and 67% specificity.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2022)
Article
Anatomy & Morphology
Sezin E. Aksakal, Ramazan Erda Pay, Caner Kose, Omer L. Tapisiz, Yaprak Engin-Ustun
Summary: This study compares several ultrasound measurements between women with pelvic inflammatory disease (PID) and healthy controls, and finds that the uterine body longitudinal and transverse axis are lower, while the cervix longitudinal axis and anterior cervical angle are higher in the PID group. These measurements can be predictors of PID.
Article
Obstetrics & Gynecology
Alperen Aksan, Berna Dilbaz, Serdar Dilbaz, Ece Ozdemir
Summary: This study analyzed the incidence of IUD dislocation and its related factors in patients who had an IUD immediately inserted after voluntary termination of pregnancy. The overall incidence of IUD dislocation was 16.3% and was not related to gestational age, but was associated with gravity and parity.
CURRENT WOMENS HEALTH REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Berna Dilbaz, Sule Atalay Mert, Elif Gulsah Diktas, Caner Kose, Yaprak Engin Ustun
Summary: This study investigated the obstetric outcomes of T/Y-shaped uterus and compared the results between T-shaped and Y-shaped uterus in patients. The results showed promising pregnancy and term delivery rates after surgery in these uterine anomalies, with better outcomes in T-shaped group for patients with recurrent pregnancy loss.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2022)
Article
Obstetrics & Gynecology
Sezin E. Aksakal, Sadiman K. Altinbas, Merve A. Ozkan, Fulya Kayikcioglu, Omer L. Tapisiz
Summary: This study presents a successful algorithm for the treatment and management of vulvar abscess, providing guidance for its treatment and management.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Biology
Raci Karayigit, Scott C. Forbes, Zakir Osmanov, Canan Yilmaz, Burak Caglar Yasli, Alireza Naderi, Hakan Buyukcelebi, Daniela Benesova, Tomasz Gabrys, Ozcan Esen
Summary: The study investigated the effects of low and moderate doses of caffeine from coffee on repeated sprint performance and plasma catecholamine concentration in trained female team-sport athletes. Results showed that caffeine ingestion can enhance the average peak power score during repeated sprints, supporting caffeine supplementation via coffee as a nutritional ergogenic aid for trained female team-sport players.
Article
Biochemistry & Molecular Biology
Kardelen Kocaman Kalkan, Serkan Sen, Belkis Narli, Cemile Merve Seymen, Canan Yilmaz
Summary: The aim of this study was to investigate the effects of quercetin on lipid and carbohydrate metabolism in a fructose-mediated metabolic syndrome (MetS) model. The results showed that quercetin administration exerted positive effects on lipid and carbohydrate metabolism, indicating its potential in the prevention and treatment of metabolic disorders.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Medicine, General & Internal
Burak Sezenoz, Serkan Unlu, Gulten Tacoy, Sedat Turkoglu, Canan Yilmaz Demirtas, Mehmet Ridvan Yalcin, Atiye Cengel, Nuri Bulent Boyaci
Summary: This study investigated the plasma levels of ghrelin in patients with pulmonary arterial hypertension (PAH) and its correlation with right ventricular (RV) function and NT-proBNP levels. The results showed no significant difference in ghrelin levels between the PAH patients and the control group. Although ghrelin may play a role in the pathogenesis of PAH, current data is insufficient to verify the exact relationship between ghrelin and PAH.
GAZI MEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Niyazi Samet Yilmaz, Bayram Sen, Burak Arslan, Tuba Saadet Deveci Bulut, Belkis Narli, Nigar Afandiyeva, Gulce Koca, Canan Yilmaz, Ozlem Gulbahar
Summary: This study implemented autoverification (AV) in a tertiary hospital to improve the efficiency of laboratory results verification and decrease turnaround time (TAT). The results showed that a significant percentage of tests achieved high AV rates during the daytime, leading to a reduction in TAT. However, there is still room for improvement in increasing the percentage of report-based verification.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)
Article
Medicine, General & Internal
Caglayan Ates, Berna Dilbaz, Seval Yilmaz Ergani, Fuad Atabay
Summary: This study aimed to investigate the effects of antiangiogenic medications (aflibercept and cabergoline) on the prevention and treatment of ovarian hyperstimulation syndrome in a rat model. The results showed that aflibercept decreased vascular permeability and vascular endothelial growth factor expression, thus alleviating ovarian hyperstimulation syndrome.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Article
Obstetrics & Gynecology
Nefise Nazli Yenigul, Runa Ozelci, Emre Baser, Serdar Dilbaz, Oya Aldemir, Berna Dilbaz, Ozlem Moraloglu Tekin
Summary: This study evaluated the effect of the rate of decline in serum estradiol levels on the success of assisted reproductive technology in women with infertility. The results showed that high ovarian responders with a 60% decrease in estradiol levels on the day of embryo transfer had lower live birth rates and higher miscarriage rates.
TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Developmental Biology
Emre Baser, Demet Aydogan Kirmizi, Runa Ozelci, Oya Aldemir, Berna Dilbaz, Serdar Dilbaz, Ozlem Moraloglu Tekin
Summary: This study investigated the pathophysiology of ovarian hyperstimulation syndrome (OHSS) and found that the neutrophil to lymphocyte (NLR) and oestradiol/progesterone (EPR) ratios were significantly higher in patients who developed OHSS. Multivariate logistic regression analysis identified NLR and EPR as independent predictors for the development of OHSS, suggesting their potential use in predicting OHSS in patients undergoing in vitro fertilisation cycles with controlled ovarian hyperstimulation.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Medicine, Research & Experimental
Fatmanur Er, Erdal Zorba, Mehmet Gunay, Mitat Koz, Canan Yilmaz, Ozge Tugce Pasaoglu, Nurten Turkozkan
Summary: The study demonstrated that the MetS model induced by fructose in rats resulted in increased blood pressure, triglycerides, and insulin resistance, and aerobic exercise training had beneficial effects on these parameters. While quercetin showed positive effects on blood pressure and insulin levels, it also led to an increase in triglycerides and body fat mass, suggesting the need for further studies to understand its mechanisms.
METABOLIC SYNDROME AND RELATED DISORDERS
(2022)