Article
Nutrition & Dietetics
Joanna Maria Pieczynska, Ewa Pruszynska-Oszmalek, Pawel Antoni Kolodziejski, Anna Lukomska, Joanna Bajerska
Summary: The study revealed that a high-fat, high-fructose diet can lead to metabolic/endocrine dysregulations in prepubertal female mice, exacerbating symptoms of Polycystic Ovarian Syndrome. It is important to be cautious of foods rich in simple sugars and saturated fats in the diet to reduce the risk of PCOS progression.
Article
Plant Sciences
Meng-fan Peng, Shuo Tian, Ya-gang Song, Cai-xia Li, Ming-san Miao, Zhen Ren, Ming Li
Summary: This study aimed to investigate the mechanism of TFEL intervention in a rat model of PCOS-IR, finding that TFEL can inhibit ovarian hyperplasia, regulate disorders of glucose and lipid metabolism, and improve the secretion of sex hormones by regulating the expression of signaling pathway-related proteins in the ovary and HPO axis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Shiya Huang, Chuyi Yu, Min Hu, Qidan Wen, Xiaohui Wen, Shuna Li, Kunyin Li, Hongxia Ma
Summary: This study evaluated the effects of low-frequency electroacupuncture on glucose and lipid disturbances in a rat model of polycystic ovary syndrome (PCOS) characterized by insulin resistance and hepatic steatosis. The results showed that electroacupuncture improved metabolic abnormalities in the PCOS-IR rat model and its mechanism may involve the regulation of key molecules in the PI3-K/Akt insulin signaling pathway in the liver.
ACUPUNCTURE IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ling Zuo, Yang Hai, Ruoyu Zhang, Biao Zuo, Jiayu Tian, Pan Li, Xiumei Ke, Meng Wang, Li Ren, Xuezhi Li, Xuekuan Huang, Jianwei Wang
Summary: This study aimed to determine the therapeutic effect and pharmacological mechanism of icariin in PCOS rats. The results showed that icariin significantly improved ovarian function and reproductive endocrine disorders by regulating sex hormones, restoring the estrous cycle, and reducing ovarian morphological damage in PCOS rats. In addition, icariin also reduced weight gain and improved glucolipid metabolism in PCOS rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Ruye Wang, Ying Zhao, Xiaohong Fang, Chenyun Miao, Ning Ren, Yun Chen, Wei Cheng, Qin Zhang
Summary: This study aimed to investigate the effects and mechanisms of action of the ketogenic diet (KD) on the gut microbiome and metabolites in PCOS rats. The results showed that feeding with a KD for 8 weeks improved the clinical phenotype and insulin resistance in PCOS rats. The KD also altered the composition of the gut microbiome and metabolites, which were associated with androgen metabolism, representing a potential mechanism for mediating the effects of the KD on sex hormone metabolism in PCOS. Evaluation: 8 points.
Article
Food Science & Technology
Bernat Miralles-Perez, Maria Rosa Nogues, Vanessa Sanchez-Martos, Angels Fortuno-Mar, Sara Ramos-Romero, Josep L. Torres, Julia Ponomarenko, Susana Amezqueta, Xiang Zhang, Marta Romeu
Summary: The present study found that increasing consumption of inulin promoted high dominance of certain bacterial genera in feces while reducing richness and diversity. Additionally, inulin decreased cardiometabolic risk factors, eicosanoid levels in the liver, and oxidative stress in blood.
Article
Plant Sciences
Javad Heshmati, Ashraf Moini, Mahdi Sepidarkish, Mojgan Morvaridzadeh, Masoud Salehi, Andriko Palmowski, Maryam Farid Mojtahedi, Farzad Shidfar
Summary: The study found that using curcumin in PCOS patients can effectively improve blood sugar and androgen levels, and is safe and reliable. Longer trials with different dosages are needed to confirm these findings.
Review
Biochemistry & Molecular Biology
Rok Herman, Jaka Sikonja, Mojca Jensterle, Andrej Janez, Vita Dolzan
Summary: Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age, characterized by hyperandrogenemia, reproductive changes, polycystic ovary morphology, and insulin resistance (IR). The primary pathophysiological process in its etiology has not yet been identified, but it is believed to involve insulin metabolism disruption and hyperandrogenemia. This review focuses on the role of insulin secretion, clearance, and decreased sensitivity in target cells as potential primary insults in PCOS pathogenesis, as well as the molecular mechanism behind IR in PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kok-Min Seow, Pin-Shiou Liu, Kuo-Hu Chen, Chien-Wei Chen, Luen-Kui Chen, Chi-Hong Ho, Jiann-Loung Hwang, Peng-Hui Wang, Chi-Chang Juan
Summary: This study investigated the mechanisms of polycystic ovary syndrome (PCOS) and the effects of letrozole on reproductive and metabolic disorders using a mouse model. Letrozole treatment resulted in disrupted estrous cycle, hormonal imbalances, formation of cystic follicles, glucose intolerance, and insulin resistance. Additionally, the expression of CCR5 and CCL5 in the perigonadal white adipose tissue was significantly higher in the letrozole-treated mice compared with the control group, and correlated with insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Maryam Kazemi, Amir Hadi, Roger A. Pierson, Marla E. Lujan, Gordon A. Zello, Philip D. Chilibeck
Summary: The study found that a diet with low glycemic index (LGI) had significant effects on improving cardiometabolic and reproductive profiles in PCOS patients, including reducing insulin resistance, improving lipid metabolism, and decreasing abdominal fat.
ADVANCES IN NUTRITION
(2021)
Article
Chemistry, Medicinal
Sowmya Shree Gopal, Shinde Vijay Sukhdeo, Baskaran Vallikannan, Ganesan Ponesakki
Summary: Lutein has antiobesity effects in a high-fat diet-induced obese mouse model, reducing adipose tissue weight, serum cholesterol, triglycerides, and blood glucose levels, as well as downregulating genes and proteins associated with obesity.
PHYTOTHERAPY RESEARCH
(2023)
Article
Obstetrics & Gynecology
Xiuxian Zhu, Yonglun Fu
Summary: This study aimed to evaluate whether extending letrozole (LE) treatment duration could induce ovulation in women with polycystic ovary syndrome (PCOS) who previously failed to ovulate after a 5-day regimen of 5 mg LE daily. The researchers found that extending LE treatment duration in a stepwise manner (2-step extended LE regimen) increased the ovulation rate without the occurrence of ovarian hyperstimulation syndrome.
FERTILITY AND STERILITY
(2023)
Article
Chemistry, Medicinal
Masoome Jabarpour, Ashraf Aleyasin, Maryam Shabani Nashtaei, Fardin Amidi
Summary: This study investigated the effect of astaxanthin on infertile polycystic ovarian syndrome (PCOS) patients. The results showed that astaxanthin improved insulin metabolism, lipid profile parameters, and oxidative stress levels in these patients. The study suggests that astaxanthin may be an effective and safe supplement.
PHYTOTHERAPY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Christopher O. Akintayo, Anjola D. Johnson, Olabimpe C. Badejogbin, Kehinde S. Olaniyi, Adesola A. Oniyide, Isaac O. Ajadi, Abdulfatai O. Ojewale, Olorunsola I. Adeyomoye, Adedeji B. Kayode
Summary: The study found that FRD increases ovarian and liver weight, but has no significant impact on hormone levels or histopathological changes in PCOS rats. However, FRD significantly alters hormone levels, resulting in histopathological changes in the fallopian tube and uterus.
Article
Medicine, Research & Experimental
Carmem Peres Valgas Da Silva, Vikram K. Shettigar, Lisa A. Baer, Eaman Abay, Kelsey M. Pinckard, Jorge Vinales, Sarah L. Sturgill, Pablo Vidal, Mark T. Ziolo, Kristin I. Stanford
Summary: This study demonstrates that aerobic exercise can significantly improve survival after myocardial infarction (MI), independent of its effects on cardiac function. However, exercise does not have an impact on obesity and glucose intolerance induced by a high-fat diet (HFD). This highlights the importance of considering environmental interventions, including diet, in the cardiac rehabilitation of obese patients.