期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 138, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.111468
关键词
Berberine; Polycystic ovary syndrome; Insulin resistance; Hyperandrogenism; Lipid metabolism
资金
- National Natural Science Foundation of China [31571196, 30801502]
- Shanghai Municipal Science and Technology Commission [18401902200, 15401932200]
- Shanghai Committee of the China Democratic League [02054]
- Shanghai Pujiang Program [11PJ1401900]
- FY2008 JSPS Postdoctoral Fellowship for Foreign Researchers [P08471]
- Special Project of the China Resources Sanjiu Medical and Pharmaceutical Co.
- Obstetrics and Gynecology Special Committee
- Chinese Association for the Integration of Traditional and Western Medicine [CR1901FC01]
- Shanghai Project for Development of Leading Disciplines-Integrative Medicine [20180101, 20150407]
PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
For women of reproductive age, polycystic ovary syndrome (PCOS) is not a rare heterogeneous endocrine disorder and metabolic dysfunction. Menstrual problems, hyperandrogenism, polycystic ovary (PCO) and infertility often affect these women, and they are also prone to metabolic syndrome (MS) and insulin resistance (IR). As an isoquinoline alkaloid, Berberine (BBR) is the main effective component of Coptis. BBR, as a multi-target, multipath plant extract, can interfere with the development of PCOS and relate to pathological process from many aspects, with less adverse reactions. It is mentioned in this review that BBR can alleviate IR, reduce the level of serum androgen, regulate lipid metabolism and moderate chronic inflammation. BBR is often used in combination with metformin, compound cyproterone (CPA) and other drugs, in order to achieve better therapeutic effect on PCOS.
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