mRNA transcript therapy

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Antibody-modified T cells: CARs take the front seat for hematologic malignancies

(2014) M. V. Maus et al.   BLOOD

Optimized dendritic cell-based immunotherapy for melanoma: the TriMix-formula

(2014) Sandra Van Lint et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Current status of therapy with omalizumab in children

(2014) Carlos E. Baena-Cagnani et al.   Current Opinion in Allergy and Clinical Immunology

Sorting out the trash: the spatial nature of eukaryotic protein quality control

(2014) Emily M Sontag et al.   CURRENT OPINION IN CELL BIOLOGY

To sense or not to sense viral RNA—essentials of coronavirus innate immune evasion

(2014) Eveline Kindler et al.   CURRENT OPINION IN MICROBIOLOGY

Emerging therapies for food allergy

(2014) Corinne A. Keet et al.   JOURNAL OF CLINICAL INVESTIGATION

Processing of Double-Stranded RNA in Mammalian Cells: A Direct Antiviral Role?

(2014) Michael P. Gantier   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Extracellular dsRNA: Its Function and Mechanism of Cellular Uptake

(2014) Srinivas Nellimarla et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients

(2013) S. Wilgenhof et al.   ANNALS OF ONCOLOGY

mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation

(2013) O. Levy et al.   BLOOD

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells

(2013) Hideyuki Okano et al.   CIRCULATION RESEARCH

Regulation and dysregulation of 3′UTR-mediated translational control

(2013) Jie Jia et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Spontaneous activation of RNA-sensing pathways in autoimmune disease

(2013) Steve P Crampton et al.   CURRENT OPINION IN IMMUNOLOGY

Parts, assembly and operation of the RIG-I family of motors

(2013) David C Rawling et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Omalizumab for treatment of allergic rhinitis

(2013) Priyanka Vashisht et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Potential therapeutic applications of RNA cap analogs

(2013) Marcin Ziemniak et al.   Future Medicinal Chemistry

Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair

(2013) T. O. Auer et al.   GENOME RESEARCH

Regimen-Specific Effects of RNA-Modified Chimeric Antigen Receptor T Cells in Mice with Advanced Leukemia

(2013) David M. Barrett et al.   HUMAN GENE THERAPY

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

A perspective on mammalian upstream open reading frame function

(2013) Joanna Somers et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Modified Foxp3 mRNA protects against asthma through an IL-10–dependent mechanism

(2013) Lauren E. Mays et al.   JOURNAL OF CLINICAL INVESTIGATION

Eukaryotic mRNA Decay: Methodologies, Pathways, and Links to Other Stages of Gene Expression

(2013) José E. Pérez-Ortín et al.   JOURNAL OF MOLECULAR BIOLOGY

The Protein Invasion: A Broad Review on the Origin of the Translational System

(2013) David W. Morgens   JOURNAL OF MOLECULAR EVOLUTION

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

(2013) Prashant Mali et al.   NATURE BIOTECHNOLOGY

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA

(2013) Benedikt Wefers et al.   Nature Protocols

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

The intimate relationships of mRNA decay and translation

(2013) Bijoyita Roy et al.   TRENDS IN GENETICS

The influence of antigen targeting to sub-cellular compartments on the anti-allergic potential of a DNA vaccine

(2013) Esther E. Weinberger et al.   VACCINE

RNA-Based Tools for Nuclear Reprogramming and Lineage-Conversion: Towards Clinical Applications

(2013) Juan A. Bernal   Journal of Cardiovascular Translational Research

mRNA

(2013) Sandra Van Lint et al.   Human Vaccines & Immunotherapeutics

Nucleic acids and endosomal pattern recognition: how to tell friend from foe?

(2013) Eva Brencicova et al.   Frontiers in Cellular and Infection Microbiology

mTOR Inhibition Improves Antitumor Effects of Vaccination with Antigen-Encoding RNA

(2013) M. Diken et al.   Cancer Immunology Research

Design of an Optimized Wilms’ Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo

(2013) Daphné Benteyn et al.   Molecular Therapy-Nucleic Acids

Sensing Microbial RNA in the Cytosol

(2013) Nicolas Vabret et al.   Frontiers in Immunology

Translational control by 3'-UTR-binding proteins

(2012) E. Szostak et al.   Briefings in Functional Genomics

Exploiting the Mutanome for Tumor Vaccination

(2012) J. C. Castle et al.   CANCER RESEARCH

Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

(2012) S. Van Lint et al.   CANCER RESEARCH

mRNA as a Versatile Tool for Exogenous Protein Expression

(2012) Andreas N. Kuhn et al.   CURRENT GENE THERAPY

Translational Control of Protein Synthesis: The Early Years

(2012) Harvey F. Lodish   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect

(2012) Mariola Fotin-Mleczek et al.   JOURNAL OF GENE MEDICINE

B Cell TLR7 Expression Drives Anti-RNA Autoantibody Production and Exacerbates Disease in Systemic Lupus Erythematosus-Prone Mice

(2012) S.-H. Hwang et al.   JOURNAL OF IMMUNOLOGY

Rectifying behavior of charge transfer complexes of tetrakis(dimethylamino)ethene with acceptor molecules: a theoretical study

(2012) Serguei Fomine   JOURNAL OF MOLECULAR MODELING

Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin

(2012) Katalin Karikó et al.   MOLECULAR THERAPY

Systemic Delivery of Modified mRNA Encoding Herpes Simplex Virus 1 Thymidine Kinase for Targeted Cancer Gene Therapy

(2012) Yuhua Wang et al.   MOLECULAR THERAPY

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

In vivo genome editing using a high-efficiency TALEN system

(2012) Victoria M. Bedell et al.   NATURE

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

(2012) Benjamin Petsch et al.   NATURE BIOTECHNOLOGY

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA

(2012) Luigi Warren et al.   Scientific Reports

Targeting the tumor mutanome for personalized vaccination therapy

(2012) Sebastian Kreiter et al.   OncoImmunology

mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients

(2011) Ellen Van Gulck et al.   AIDS

FLT3 Ligand Enhances the Cancer Therapeutic Potency of Naked RNA Vaccines

(2011) S. Kreiter et al.   CANCER RESEARCH

A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption

(2011) Sabine D. Allard et al.   CLINICAL IMMUNOLOGY

Tumor vaccination using messenger RNA: prospects of a future therapy

(2011) Sebastian Kreiter et al.   CURRENT OPINION IN IMMUNOLOGY

mRNA vaccination as a safe approach for specific protection from type I allergy

(2011) Richard Weiss et al.   Expert Review of Vaccines

Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells

(2011) David M. Barrett et al.   HUMAN GENE THERAPY

Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery

(2011) Bin Shi et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

(2011) Leif E. Sander et al.   NATURE

Genetic engineering of human pluripotent cells using TALE nucleases

(2011) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

Knockout rats generated by embryo microinjection of TALENs

(2011) Laurent Tesson et al.   NATURE BIOTECHNOLOGY

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

(2011) B. R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway

(2011) Christina Lorenz et al.   RNA Biology

Targeted Genome Editing Across Species Using ZFNs and TALENs

(2011) Andrew J. Wood et al.   SCIENCE

Engineering a Direct and Inducible Protein−RNA Interaction To Regulate RNA Biology

(2010) Brian J. Belmont et al.   ACS Chemical Biology

Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors

(2010) Eduard Yakubov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Particle size and activation threshold: a new dimension of danger signaling

(2010) L. Rettig et al.   BLOOD

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

(2010) S. Kreiter et al.   CANCER RESEARCH

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

(2010) Y. Zhao et al.   CANCER RESEARCH

Prophylactic mRNA vaccination against allergy

(2010) Richard Weiss et al.   Current Opinion in Allergy and Clinical Immunology

Transiently redirected T cells for adoptive transfer

(2010) Hilde Almåsbak et al.   CYTOTHERAPY

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

(2010) A N Kuhn et al.   GENE THERAPY

Delivery of Immunostimulatory RNA Oligonucleotides by Gelatin Nanoparticles Triggers an Efficient Antitumoral Response

(2010) Carole Bourquin et al.   JOURNAL OF IMMUNOTHERAPY

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

(2010) Mariola Fotin-Mleczek et al.   JOURNAL OF IMMUNOTHERAPY

RNA Interference Advances to Early-Stage Clinical Trials

(2010) V. Brower   JNCI-Journal of the National Cancer Institute

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

(2010) Susanne M Rittig et al.   MOLECULAR THERAPY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

(2010) Bart R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy

(2009) Jean-Pierre Routy et al.   CLINICAL IMMUNOLOGY

Clinical-grade manufacturing of autologous mature mRNA-electroporated dendritic cells and safety testing in acute myeloid leukemia patients in a phase I dose-escalation clinical trial

(2009) Ann Van Driessche et al.   CYTOTHERAPY

Immunize and disappear—Safety-optimized mRNA vaccination with a panel of 29 allergens

(2009) Elisabeth Roesler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

(2009) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE

Ectopic expression of a truncated CD40L protein from synthetic post-transcriptionally capped RNA in dendritic cells induces high levels of IL-12 secretion

(2008) Irina Y Tcherepanova et al.   BMC MOLECULAR BIOLOGY

Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products

(2008) Eugen Koren et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Cytokine Maturation Followed by CD40L mRNA Electroporation Results in a Clinically Relevant Dendritic Cell Product Capable of Inducing a Potent Proinflammatory CTL Response

(2008) David M. Calderhead et al.   JOURNAL OF IMMUNOTHERAPY

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

(2008) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA

(2008) Aude Bonehill et al.   MOLECULAR THERAPY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

Translational control of localized mRNAs: restricting protein synthesis in space and time

(2008) Florence Besse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Efficient cytosolic delivery of molecular beacon conjugates and flow cytometric analysis of target RNA

(2008) A. K. Chen et al.   NUCLEIC ACIDS RESEARCH

Quantitative Effect of Suboptimal Codon Usage on Translational Efficiency of mRNA Encoding HIV-1 gag in Intact T Cells

(2008) Kholiswa C. Ngumbela et al.   PLoS One

Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

(2008) J. Kowalska et al.   RNA

Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

(2008) S. R. Nallagatla et al.   RNA

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY