Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery

Systemic siRNA delivery to leukocyte-implicated diseases

(2011) Dan Peer et al.   CELL CYCLE

Efficient and targeted delivery of siRNA in vivo

(2010) Min Suk Shim et al.   FEBS Journal

Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice

(2010) Manabu Kinoshita et al.   JOURNAL OF HEPATOLOGY

Noninvasive Imaging of Lipid Nanoparticle–Mediated Systemic Delivery of Small-Interfering RNA to the Liver

(2010) Weikang Tao et al.   MOLECULAR THERAPY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Effect of biological matrix and sample preparation on qPCR quantitation of siRNA drugs in animal tissues

(2010) Jessica Seitzer et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Lentiviral delivery of short hairpin RNAs

(2009) N. Manjunath et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipid-based systemic delivery of siRNA

(2009) Yu-Cheng Tseng et al.   ADVANCED DRUG DELIVERY REVIEWS

Effect of Poly(N-vinyl-pyrrolidone)-block-poly(d,l-lactide) as Coating Agent on the Opsonization, Phagocytosis, and Pharmacokinetics of Biodegradable Nanoparticles

(2009) Geneviève Gaucher et al.   BIOMACROMOLECULES

Influence of PEG chain on the complement activation suppression and longevity in vivo prolongation of the PCL biomedical nanoparticles

(2009) Xiaoqian Shan et al.   BIOMEDICAL MICRODEVICES

Peptide Mediated siRNA Delivery

(2009) Mousa Jafari et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Systemic Delivery and Quantification of Unformulated Interfering RNAs In Vivo

(2009) Aurelie Morin et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Overcoming obstacles to develop effective and safe siRNA therapeutics

(2009) Leiming Li et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis

(2009) Janie L. Baratta et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging

(2009) Olivia M. Merkel et al.   JOURNAL OF CONTROLLED RELEASE

Neutrophils Sequestered in the Liver Suppress the Proinflammatory Response of Kupffer Cells to Systemic Bacterial Infection

(2009) M. Holub et al.   JOURNAL OF IMMUNOLOGY

Dicer is required for proper liver zonation

(2009) Shigeki Sekine et al.   JOURNAL OF PATHOLOGY

Tracking the Relative In Vivo Pharmacokinetics of Nanoparticles with PARACEST MRI

(2009) M. Meser Ali et al.   MOLECULAR PHARMACEUTICS

A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery

(2009) James J. Lu et al.   MOLECULAR PHARMACEUTICS

The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice

(2009) Shan Gao et al.   MOLECULAR THERAPY

Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment

(2009) Marc T Abrams et al.   MOLECULAR THERAPY

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

Gold nanocages covered by smart polymers for controlled release with near-infrared light

(2009) Mustafa S. Yavuz et al.   NATURE MATERIALS

miRNA in situ hybridization in formaldehyde and EDC–fixed tissues

(2009) John T G Pena et al.   NATURE METHODS

Stem-Loop RT-PCR Quantification of siRNAs In Vitro and In Vivo

(2009) Angie Cheng et al.   OLIGONUCLEOTIDES

Therapeutic Applications of DNA and RNA Aptamers

(2009) Kristina W. Thiel et al.   OLIGONUCLEOTIDES

In Vivo SPECT and Real-Time Gamma Camera Imaging of Biodistribution and Pharmacokinetics of siRNA Delivery Using an Optimized Radiolabeling and Purification Procedure

(2008) Olivia M. Merkel et al.   BIOCONJUGATE CHEMISTRY

BARRIERS TO SUCCESSFUL DELIVERY OF SHORT INTERFERING RNA AFTER SYSTEMIC ADMINISTRATION

(2008) Paul J White   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Challenges and Opportunities for Local and Systemic Delivery of siRNA and Antisense Oligonucleotides

(2008) L Sepp-Lorenzino et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Tumor-targeted delivery of siRNA by non-viral vector: safe and effective cancer therapy

(2008) Yunching Chen et al.   Expert Opinion on Drug Delivery

Efficient Inhibition of Hepatitis B Virus Replication In Vivo, Using Polyethylene Glycol-Modified Adenovirus Vectors

(2008) Carol Crowther et al.   HUMAN GENE THERAPY

Polymersome delivery of siRNA and antisense oligonucleotides

(2008) Younghoon Kim et al.   JOURNAL OF CONTROLLED RELEASE

Characterization of the gene delivery properties of baculoviral-based virosomal vectors

(2008) Ghiabe-Henri Guibinga et al.   JOURNAL OF VIROLOGICAL METHODS

Sustained delivery of siRNAs targeting viral infection by cell-degradable multilayered polyelectrolyte films

(2008) M. Dimitrova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development and Application of Glycosylated Particulate Carriers for Delivery of Nucleic Acid Medicine

(2008) Shigeru KAWAKAMI   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells

(2007) Jeffrey S. Smith et al.   JOURNAL OF VIROLOGICAL METHODS