14-3-3 zeta as novel molecular target for cancer therapy

14-3-3ζ binds class III phosphatidylinositol-3-kinase and inhibits autophagy

(2011) Mercedes Pozuelo-Rubio   Autophagy

Silencing of 14-3-3ζ over-expression in hepatocellular carcinoma inhibits tumor growth and enhances chemosensitivity to cis-diammined dichloridoplatium

(2011) Jung Eun Choi et al.   CANCER LETTERS

Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit

(2011) C L Neal et al.   ONCOGENE

Identification of proteins secreted by head and neck cancer cell lines using LC-MS/MS: Strategy for discovery of candidate serological biomarkers

(2011) Ranju Ralhan et al.   PROTEOMICS

14-3-3 proteins as signaling integration points for cell cycle control and apoptosis

(2011) Alexandra K. Gardino et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Ras-ERK pathway: Understanding site-specific signaling provides hope of new anti-tumor therapies

(2010) Fernando Calvo et al.   BIOESSAYS

Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein–protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis

(2010) Valentina Corradi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in Head and Neck cancer cells

(2010) Muzafar A Macha et al.   BMC CANCER

A Panel of Sputum-Based Genomic Marker for Early Detection of Lung Cancer

(2010) F. Jiang et al.   Cancer Prevention Research

MicroRNA-375 Is Downregulated in Gastric Carcinomas and Regulates Cell Survival by Targeting PDK1 and 14-3-3 

(2010) Y. Tsukamoto et al.   CANCER RESEARCH

Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase

(2010) M Pozuelo-Rubio   CELL DEATH AND DIFFERENTIATION

14-3-3ζ Overexpression and abnormal β-catenin expression are associated with poor differentiation and progression in stage I non-small cell lung cancer

(2010) Dongyu Zang et al.   CLINICAL AND EXPERIMENTAL MEDICINE

14-3-3ζ as a prognostic marker and therapeutic target for cancer

(2010) Christopher L Neal et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3 

(2010) D. M. Patrick et al.   GENES & DEVELOPMENT

Prognostic significance of nuclear pSTAT3 in oral cancer

(2010) Muzafar A. Macha et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Clinical significance of TC21 overexpression in oral cancer

(2010) Muzafar A. Macha et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

A New Nonpeptidic Inhibitor of 14-3-3 Induces Apoptotic Cell Death in Chronic Myeloid Leukemia Sensitive or Resistant to Imatinib

(2010) M. Mancini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification of Novel 14-3-3ζ Interacting Proteins by Quantitative Immunoprecipitation Combined with Knockdown (QUICK)

(2010) Feng Ge et al.   JOURNAL OF PROTEOME RESEARCH

LC−MS/MS Analysis of Ovarian Cancer Metastasis-Related Proteins Using a Nude Mouse Model: 14-3-3 Zeta as a Candidate Biomarker

(2010) Yifeng He et al.   JOURNAL OF PROTEOME RESEARCH

Small Interfering RNA Targeting 14-3-3  Increases Efficacy of Chemotherapeutic Agents in Head and Neck Cancer Cells

(2010) A. Matta et al.   MOLECULAR CANCER THERAPEUTICS

14-3-3 sigma and 14-3-3 zeta plays an opposite role in cell growth inhibition mediated by transforming growth factor-beta 1

(2010) Hye-Young Hong et al.   MOLECULES AND CELLS

Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer

(2010) Yang Li et al.   NATURE MEDICINE

DNA damage stress response in germ cells: role of c-Abl and clinical implications

(2010) S Gonfloni   ONCOGENE

Breast cancer metastasis driven by ErbB2 and 14-3-3ξ

(2010) Yingqun Wang   Cell Adhesion & Migration

Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice

(2009) Weidong Cao et al.   APOPTOSIS

14-3-3ζ Cooperates with ErbB2 to Promote Ductal Carcinoma In Situ Progression to Invasive Breast Cancer by Inducing Epithelial-Mesenchymal Transition

(2009) Jing Lu et al.   CANCER CELL

14-3-3  Overexpression Defines High Risk for Breast Cancer Recurrence and Promotes Cancer Cell Survival

(2009) C. L. Neal et al.   CANCER RESEARCH

α3β1 integrin promotes cell survival via multiple interactions between 14-3-3 isoforms and proapoptotic proteins

(2009) Ju-Eun Oh et al.   EXPERIMENTAL CELL RESEARCH

Copy number gain and oncogenic activity of YWHAZ/14-3-3ζ in head and neck squamous cell carcinoma

(2009) Mauting Lin et al.   INTERNATIONAL JOURNAL OF CANCER

Dimerization Is Essential for 14-3-3ζ Stability and Functionin Vivo

(2009) Georgia Messaritou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

14-3-3ζ Mediates Resistance of Diffuse Large B Cell Lymphoma to an Anthracycline-based Chemotherapeutic Regimen

(2009) Steve A. Maxwell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine 58 of 14-3-3  Is a Molecular Switch Regulating ASK1 and Oxidant Stress-Induced Cell Death

(2009) J. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

14-3-3 zeta protein secreted by tumor associated monocytes/macrophages from ascites of epithelial ovarian cancer patients

(2008) Ryuji Kobayashi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

14-3-3  Down-regulates p53 in Mammary Epithelial Cells and Confers Luminal Filling

(2008) C. G. Danes et al.   CANCER RESEARCH

Cytoplasmic accumulation of activated leukocyte cell adhesion molecule is a predictor of disease progression and reduced survival in oral cancer patients

(2008) Meenakshi Sawhney et al.   INTERNATIONAL JOURNAL OF CANCER

Prognostic Significance of Head-and-Neck Cancer Biomarkers Previously Discovered and Identified Using iTRAQ-Labeling and Multidimensional Liquid Chromatography−Tandem Mass Spectrometry

(2008) Ajay Matta et al.   JOURNAL OF PROTEOME RESEARCH

iTRAQ-Multidimensional Liquid Chromatography and Tandem Mass Spectrometry-Based Identification of Potential Biomarkers of Oral Epithelial Dysplasia and Novel Networks between Inflammation and Premalignancy

(2008) Ranju Ralhan et al.   JOURNAL OF PROTEOME RESEARCH

Discovery and Verification of Head-and-neck Cancer Biomarkers by Differential Protein Expression Analysis Using iTRAQ Labeling, Multidimensional Liquid Chromatography, and Tandem Mass Spectrometry

(2008) Ranju Ralhan et al.   MOLECULAR & CELLULAR PROTEOMICS

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

(2008) Deborah K. Morrison   TRENDS IN CELL BIOLOGY