PTP1B inhibitors for type 2 diabetes treatment: a patent review (2011 – 2014)

Diphenylether Derivative as Selective Inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) Over T-cell Protein Tyrosine Phosphatase (TCPTP) Identified through Virtual Screening

(2015) M. Reddy et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B

(2014) Ying Zhi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Discovery of a Novel and Selective Inhibitor of PTP1B Over TCPTP: 3D QSAR Pharmacophore Modeling, Virtual Screening, Synthesis, and Biological Evaluation

(2014) Ying Ma et al.   Chemical Biology & Drug Design

3-Phenylpropanoic Acid-Based Phosphotyrosine (pTyr) Mimetics: Hit Evolution to a Novel Orally Active Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitor

(2014) Yan-Bo Tang et al.   ChemMedChem

New compounds from acid hydrolyzed products of the fruits of Momordica charantia L. and their inhibitory activity against protein tyrosine phosphatas 1B

(2014) Ke Zeng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors

(2014) Jian-Peng Yin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bidentate Inhibitors of Protein Tyrosine Phosphatases

(2013) Joo-Leng Low et al.   ANTIOXIDANTS & REDOX SIGNALING

Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors

(2013) Lin-Fu Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors

(2013) Yan-Bo Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural characterization and bioactivity evaluation of an acidic proteoglycan extract fromGanoderma lucidumfruiting bodies for PTP1B inhibition and anti-diabetes

(2013) Deng Pan et al.   BIOPOLYMERS

Pharmacological Inhibition of Protein Tyrosine Phosphatase 1B: A Promising Strategy for the Treatment of Obesity and Type 2 Diabetes Mellitus

(2013) E. Panzhinskiy et al.   CURRENT MEDICINAL CHEMISTRY

Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors from Morinda citrifolia (Noni) and Their Insulin Mimetic Activity

(2013) Phi-Hung Nguyen et al.   JOURNAL OF NATURAL PRODUCTS

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

(2012) Cheng-shi Jiang et al.   ACTA PHARMACOLOGICA SINICA

QSAR Studies of PTP1B Inhibitors: Recent Advances and Perspectives

(2012) F. Luan et al.   CURRENT MEDICINAL CHEMISTRY

PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis

(2012) Tony Tiganis   FEBS Journal

Unprecedented Diterpenoids as a PTP1B Inhibitor from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller

(2012) Lin-Fu Liang et al.   ORGANIC LETTERS

Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP–1B: In vitro, in silico, and in vivo approaches

(2011) Juan José Ramírez-Espinosa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Berberine inhibits PTP1B activity and mimics insulin action

(2010) Chunhua Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Self-organizing molecular field analysis of 2,4-thiazolidinediones: A 3D-QSAR model for the development of human PTP1B inhibitors

(2010) Suresh Thareja et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development

(2010) Alastair J Barr   Future Medicinal Chemistry

Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus

(2010) Suresh Thareja et al.   MEDICINAL RESEARCH REVIEWS

Docking Simulations and in Vitro Assay Unveil Potent Inhibitory Action of Papaverine against Protein Tyrosine Phosphatase 1B

(2009) Yasser Bustanji et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Genistein-Derivatives from Tetracera scandens Stimulate Glucose-Uptake in L6 Myotubes

(2009) Myung Sun Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis

(2009) Duc Manh Hoang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects

(2009) Bharat Raj Bhattarai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B

(2009) Goo Yoon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B

(2009) Juan Zhang et al.   FOOD CHEMISTRY

Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues

(2009) B. Xue et al.   MOLECULAR AND CELLULAR BIOLOGY

Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a phosphatidylinositol 3-kinase-independent manner

(2009) Baddireddi Subhadra LAKSHMI et al.   Journal of Diabetes

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits

(2008) Akhilesh K. Tamrakar et al.   JOURNAL OF ETHNOPHARMACOLOGY

Prodrugs of Phosphates and Phosphonates

(2008) Scott J. Hecker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triterpenoids and a sterol from the stem-bark ofStyrax japonicaand their protein tyrosine phosphatase 1B inhibitory activities

(2008) Joo-Hee Kwon et al.   PHYTOTHERAPY RESEARCH

Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines

(2007) Brent Douty et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats

(2005) Yong Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY