Recently patented and promising ORL-1 ligands: where have we been and where are we going?

Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile

(2009) N. Dietis et al.   BRITISH JOURNAL OF ANAESTHESIA

Activity of new NOP receptor ligands in a rat peripheral mononeuropathy model: Potentiation of morphine anti-allodynic activity by NOP receptor antagonists

(2009) Taline V. Khroyan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

1-Benzyl-N-[3-[spiroisobenzofuran-1(3H),4′-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (Compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices

(2009) Yan-Yu Liao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24

(2009) Carmela Fischetti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Generalized Anxiety Disorder and Medical Illness

(2009) Larry Culpepper   JOURNAL OF CLINICAL PSYCHIATRY

Identification of an Orally Active Opioid Receptor-like 1 (ORL1) Receptor Antagonist 4-{3-[(2R)-2,3-Dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1′-cyclopropan]-3-ylmethyl]piperidine as Clinical Candidate

(2009) Atsushi Satoh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antinociceptive Effects of Nociceptin/Orphanin FQ Administered Intrathecally in Monkeys

(2009) Mei-Chuan Ko et al.   JOURNAL OF PAIN

Nociceptin/Orphanin FQ Receptor Activation Attenuates Antinociception Induced by Mixed Nociceptin/Orphanin FQ/ -Opioid Receptor Agonists

(2009) T. V. Khroyan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain

(2009) Giovanna M. Scoto et al.   LIFE SCIENCES

Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms

(2009) Celia Goeldner et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Selective and high affinity labeling of neuronal and recombinant nociceptin receptors with the hexapeptide radioprobe [3H]Ac-RYYRIK-ol

(2009) Engin Bojnik et al.   NEUROCHEMISTRY INTERNATIONAL

Behavioral Effects of a Synthetic Agonist Selective for Nociceptin/Orphanin FQ Peptide Receptors in Monkeys

(2009) Mei-Chuan Ko et al.   NEUROPSYCHOPHARMACOLOGY

Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112

(2009) Eric Hu et al.   PAIN

The ORL-1 Receptor System: Are There Opportunities for Antagonists in Pain Therapy?

(2008) Beatriz Fioravanti et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Anxiety disorders and comorbid medical illness

(2008) Peter P. Roy-Byrne et al.   GENERAL HOSPITAL PSYCHIATRY

The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA

(2008) Matteo Marti et al.   JOURNAL OF NEUROCHEMISTRY

The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

(2008) David G. Lambert   NATURE REVIEWS DRUG DISCOVERY

Activities of mixed NOP and μ-opioid receptor ligands

(2007) B Spagnolo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations

(2007) Robert H. Dworkin et al.   JOURNAL OF PAIN