Article
Environmental Sciences
Weiyu Huang, Zijiang Wang, Gaoyang Wang, Kunyang Li, Yaping Jin, Fenghong Zhao
Summary: This study demonstrates that long-term exposure to 1,2-DCE impairs learning and memory capacity in mice, possibly due to disrupted glutamate metabolism and inhibition of the CaM-CaMKII-CREB signaling pathway in the hippocampus.
ENVIRONMENTAL POLLUTION
(2022)
Article
Neurosciences
Tongjie Ji, Ying Pang, Meng Cheng, Rui Wang, Xu Chen, Chunyu Zhang, Min Liu, Jing Zhang, Chunlong Zhong
Summary: In this study, it was found that deletion of GCPII can reduce glutamate production, protect neurons from damage, and improve cognitive function, while deletion of GCPIII has no significant neuroprotective effect. In addition, there is no significant difference in the neuroprotective effect between the combination of GCPII and GCPIII deletion and GCPII deletion alone.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Francesca Liberatore, Nico Antenucci, Daniel Tortolani, Giada Mascio, Federico Fanti, Manuel Sergi, Giuseppe Battaglia, Valeria Bruno, Ferdinando Nicoletti, Mauro Maccarrone, Serena Notartomaso
Summary: Research has shown that using mGlu1 receptor PAM can partially correct learning deficits in SCA1 mouse models, restore memory retention, and increase levels of endocannabinoid anandamide in the hippocampus.
Article
Neurosciences
Wei Zhu, Fengming Wu, Jiong Li, Lianghui Meng, Wenjun Zhang, Huijie Zhang, Shuhan Cha, Jifeng Zhang, Guoqing Guo
Summary: Hyperthyroidism can impair excitatory synaptic transmission in the hippocampus, affecting learning and memory functions. Activation of AMPA and NMDA receptors can restore excitatory synaptic function and improve learning and memory deficits in hyperthyroid mice.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Ping Liu, Hengyan Shen, Qiaoyue Zhang, Limei Zhou, Xinyu Bai, Tao Zhang
Summary: This study found that Lonicera japonica polysaccharide can inhibit the cue-induced reinstatement of alcohol addiction memory, mitigate hippocampal neuronal damage, and reduce abnormal enhancement of alcohol-induced addiction memory. Additionally, VPS34 was identified as a potential target for modulating alcohol cravings.
Review
Biochemistry & Molecular Biology
Massimo Ubaldi, Nazzareno Cannella, Anna Maria Borruto, Michele Petrella, Maria Vittoria Micioni Di Bonaventura, Laura Soverchia, Serena Stopponi, Friedbert Weiss, Carlo Cifani, Roberto Ciccocioppo
Summary: Nociceptin/orphanin FQ (N/OFQ) is a neuropeptide that binds the NOP receptor and exerts anti-opioids effects; the NOP receptor is widely expressed in the brain, while N/OFQ is mainly localized in stress-related brain nuclei; preclinical evidence suggests that both NOP agonists and antagonists may be effective therapeutic approaches for substance use disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
J. M. Wilcox, D. C. Consoli, A. A. Tienda, S. Dixit, R. A. Buchanan, J. M. May, W. P. Nobis, F. E. Harrison
Summary: Repeated low-dose kainic acid treatment triggered non-convulsive epileptiform activity in APP/PSEN1 mice, leading to memory impairment and hippocampal long-term potentiation deficits. The high excitability in Alzheimer's disease may contribute to cognitive decline independently of beta-amyloid-plaque load, especially in younger mice without plaques.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Pharmacology & Pharmacy
Yin Cao, Qinglin Li, An Zhou, Zunji Ke, Shengqi Chen, Mingrui Li, Zipeng Gong, Zhengtao Wang, Xiaojun Wu
Summary: This study demonstrates that notoginsenoside R1 (NGR1) extracted from Panax notoginseng can improve impaired learning and memory in sleep deprived mice by reducing excessive autophagy and apoptosis of hippocampal neurons through modulation of the MTNR1A-mediated PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Flora D'Oliveira da Silva, Joaquim Azevedo Neto, Chiara Sturaro, Annunziata Guarino, Cathaline Robert, Elaine C. Gavioli, Girolamo Calo, Lionel Mouledous, Chiara Ruzza
Summary: The study found that the NOP receptor antagonist BTRX-246040 has antidepressant effects and can prevent the development of helplessness behavior. This research provides evidence for the innovative strategy of blocking NOP signaling for the treatment of stress-related psychopathologies.
Article
Neurosciences
Xiao Liu, Su-Su Tang, Si-Ming Liu, Jie Zeng, Zhi-Gang Chen, Cai-Hong Liu, Rong-Hao Mu, Dan-Hua Yuan, Jia-Jia Zhao, Hao Hong, Hao Wang
Summary: Astrocyte CysLT(1)R regulates depression through modulating glutamate synaptic transmission. This finding is of significant importance for developing novel drugs for depression treatment.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Pengbo Shi, Zhaosu Li, Teng He, Nanqin Li, Xing Xu, Peiyao Yu, Xue Lu, Jiaxun Nie, Dekang Liu, Qinglong Cai, Yun Guan, Feifei Ge, Jun Wang, Xiaowei Guan
Summary: The study revealed that METH withdrawal disrupted spatial memory in mice, associated with increased Glu levels and postsynaptic neuronal activities at dCA1 synapses. METH withdrawal weakened the capacity of Glu clearance in astrocytes, while it did not affect the presynaptic Glu release from dCA3 within dCA1.
Article
Immunology
Yosuke Danjo, Eiji Shigetomi, Yukiho J. Hirayama, Kenji Kobayashi, Tatsuya Ishikawa, Yugo Fukazawa, Keisuke Shibata, Kenta Takanashi, Bijay Parajuli, Youichi Shinozaki, Sun Kwang Kim, Junichi Nabekura, Schuichi Koizumi
Summary: The activation of astrocytes plays a crucial role in brain plasticity and the development of neurological disorders. The presence of mGluR5 in astrocytes, which is absent under normal conditions, is essential for regulating synaptic plasticity and neuronal activity, particularly in the somatosensory cortex.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Ahmed Salim Mahmood, Afaq M. Ammoo, Mayssam Hussein Mohammed Ali, Tiba M. Hameed, Hany A. Al-Hussaniy, Abdulla Amer Abbas Aljumaili, Mohammed Hussein Alaa Al-Fallooji, Ali Hakim Kadhim
Summary: NeuroAid, a traditional Chinese medicine, has been found to have significant effects in preventing epilepsy by reducing seizure severity, prolonging seizure onset, and decreasing the number and duration of seizures.
Article
Neurosciences
Chunhua Liu, Qun Li, Zekang Wu, Shengwen Wang, Zhuo Yang, Tao Zhang
Summary: Cognitive dysfunction is a common occurrence in diabetes mellitus (DM), but the relationship between DM-induced cognitive defects and neuronal network oscillations is still not well understood. This study aimed to investigate the effects of DM on the hippocampal neural network and found that dysfunction of metabotropic glutamate receptors (mGluRs) may contribute to the alterations in neural network activity.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Engineering, Environmental
Chiang-Wen Lee, Lee-Fen Hsu, I-Lin Wu, Yung-Li Wang, Wei-Chen Chen, Yan-Jun Liu, Lu-Tang Yang, Chong-Lun Tan, Yueh-Hsia Luo, Chia-Ching Wang, Hui-Wen Chiu, Thomas Chung-Kuang Yang, Yen-Yue Lin, Hsin-An Chang, Yao-Chang Chiang, Ching-Hsiang Chen, Ming-Hsueh Lee, Kuo-Ti Peng, Cathy Chia-Yu Huang
Summary: Exposure to polystyrene microplastics impairs learning and memory in mice, especially in the hippocampus, and the memory function can be improved by ablation of the vagus nerve.
JOURNAL OF HAZARDOUS MATERIALS
(2022)