Emerging therapeutic interventions for idiopathic pulmonary fibrosis

Peptide-Mediated Inhibition of Mitogen-Activated Protein Kinase–Activated Protein Kinase–2 Ameliorates Bleomycin-Induced Pulmonary Fibrosis

(2013) Ragini Vittal et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Thalidomide for the Treatment of Cough in Idiopathic Pulmonary Fibrosis

(2013) Maureen R. Horton et al.   ANNALS OF INTERNAL MEDICINE

Treatment of Idiopathic Pulmonary Fibrosis With Ambrisentan

(2013) Ganesh Raghu   ANNALS OF INTERNAL MEDICINE

Hepatocyte growth factor is an attractive target for the treatment of pulmonary fibrosis

(2013) Sushmita Chakraborty et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

PI3K p110γ overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitro effects of its inhibition

(2013) Enrico Conte et al.   LABORATORY INVESTIGATION

Endostatin, an angiogenesis inhibitor, ameliorates bleomycin-induced pulmonary fibrosis in rats

(2013) Yun-Yan Wan et al.   RESPIRATORY RESEARCH

Octreotide treatment of idiopathic pulmonary fibrosis: a proof-of-concept study

(2012) B. Crestani et al.   EUROPEAN RESPIRATORY JOURNAL

Delivery and Safety of Inhaled Interferon-γ in Idiopathic Pulmonary Fibrosis

(2012) Keith T. Diaz et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3

(2011) Alison C. MacKinnon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

(2011) Véronique Plantevin Krenitsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis

(2011) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis

(2011) MONIQUE A. MALOUF et al.   RESPIROLOGY

Bleomycin revisited: towards a more representative model of IPF?

(2010) Chris J. Scotton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Clinical Course and Prediction of Survival in Idiopathic Pulmonary Fibrosis

(2010) Brett Ley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A phosphoinositide 3-kinase-γ inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats

(2010) Xin Wei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Safety and Tolerability of Inhaled Heparin in Idiopathic Pulmonary Fibrosis

(2010) Philipp Markart et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice

(2010) Remo C. Russo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

A Controlled Trial of Sildenafil in Advanced Idiopathic Pulmonary Fibrosis

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Vasohibin attenuates bleomycin induced pulmonary fibrosis via inhibition of angiogenesis in mice

(2010) Xingsheng Wang et al.   PATHOLOGY

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts

(2010) N. Amara et al.   THORAX

Pirfenidone: antifibrotic agent for idiopathic pulmonary fibrosis

(2010) Arata Azuma   Expert Review of Respiratory Medicine

Imatinib Treatment for Idiopathic Pulmonary Fibrosis

(2009) Craig E. Daniels et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Potential Role of Endothelin-1 in Pulmonary Fibrosis

(2009) Bryan Ross et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pirfenidone in idiopathic pulmonary fibrosis

(2009) H. Taniguchi et al.   EUROPEAN RESPIRATORY JOURNAL

Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial

(2009) Talmadge E King et al.   LANCET

Bone Marrow Stem Cells Expressing Keratinocyte Growth Factor via an Inducible Lentivirus Protects against Bleomycin-Induced Pulmonary Fibrosis

(2009) Susana Aguilar et al.   PLoS One

Improvement of bleomycin-induced pulmonary hypertension and pulmonary fibrosis by the endothelin receptor antagonist Bosentan

(2009) Stephan Schroll et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Treatment of Idiopathic Pulmonary Fibrosis with Etanercept

(2008) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

c-Jun N-Terminal Kinase 1 Is Required for the Development of Pulmonary Fibrosis

(2008) John F. Alcorn et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy

(2008) F. Hilberg et al.   CANCER RESEARCH

Interleukin-13 acts as an apoptotic effector on lung epithelial cells and induces pro-fibrotic gene expression in lung fibroblasts

(2008) A. Borowski et al.   CLINICAL AND EXPERIMENTAL ALLERGY

From lung injury to fibrosis

(2008) Klaus Ley et al.   NATURE MEDICINE

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

BUILD-1: A Randomized Placebo-controlled Trial of Bosentan in Idiopathic Pulmonary Fibrosis

(2007) Talmadge E. King et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Activation of somatostatin receptors attenuates pulmonary fibrosis

(2007) R Borie et al.   THORAX