Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice

Phosphoinositide-3 Kinase γ Activity Contributes to Sepsis and Organ Damage by Altering Neutrophil Recruitment

(2010) Erica L. Martin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Involvement of Phosphoinositide 3-Kinase γ in Angiogenesis and Healing of Experimental Myocardial Infarction in Mice

(2010) Mauro Siragusa et al.   CIRCULATION RESEARCH

PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-κB-independent manner

(2010) Lirlândia P. Sousa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of PI3K by PX-866 Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis

(2009) Timothy D. Le Cras et al.   AMERICAN JOURNAL OF PATHOLOGY

Phosphatidylinositol-3-Kinase/Akt Regulates Bleomycin-Induced Fibroblast Proliferation and Collagen Production

(2009) Yongju Lu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-κB

(2009) Lirlândia P. Sousa et al.   BIOCHEMICAL PHARMACOLOGY

Phosphoinositide 3-kinase   required for lipopolysaccharide-induced transepithelial neutrophil trafficking in the lung

(2009) J. Reutershan et al.   EUROPEAN RESPIRATORY JOURNAL

Fine tuning the immune response with PI3K

(2009) David A. Fruman et al.   IMMUNOLOGICAL REVIEWS

Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis

(2009) Borna Mehrad et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase γ–deficient mice

(2009) Masahide Takeda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Role for a CXCR2/Phosphatidylinositol 3-Kinase   Signaling Axis in Acute and Chronic Vascular Permeability

(2009) J. Gavard et al.   MOLECULAR AND CELLULAR BIOLOGY

Pulmonary fibrosis: pathogenesis, etiology and regulation

(2009) M S Wilson et al.   Mucosal Immunology

Regulation of phosphoinositide 3-kinase expression in health and disease

(2009) Klaartje Kok et al.   TRENDS IN BIOCHEMICAL SCIENCES

Transepithelial Migration of Neutrophils

(2008) Rachel L. Zemans et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Role of the Chemokine Receptor CXCR2 in Bleomycin-Induced Pulmonary Inflammation and Fibrosis

(2008) Remo C. Russo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Overlapping and distinct roles for PI3Kβ and γ isoforms in S1P-induced migration of human and mouse endothelial cells

(2008) Regine Heller et al.   CARDIOVASCULAR RESEARCH

Inhibition of PI-3 kinase for treating respiratory disease: good idea or bad idea?

(2008) M THOMAS et al.   CURRENT OPINION IN PHARMACOLOGY

Hyper-responsiveness of IPF/UIP fibroblasts: Interplay between TGFβ1, IL-13 and CCL2

(2008) Lynne A. Murray et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Aerosolized Phosphoinositide 3-Kinase  /  Inhibitor TG100-115 [3-[2,4-Diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a Therapeutic Candidate for Asthma and Chronic Obstructive Pulmonary Disease

(2008) J. Doukas et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

An Essential Role for Fibronectin Extra Type III Domain A in Pulmonary Fibrosis

(2007) Andrés F. Muro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phosphoinositide 3-Kinase γ Gene Knockout Impairs Postischemic Neovascularization and Endothelial Progenitor Cell Functions

(2007) Paolo Madeddu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY