PDE inhibitors currently in early clinical trials for the treatment of asthma

ABCD of the phosphodiesterase family: interaction and differential activity in COPD

(2016) David Halpin   International Journal of Chronic Obstructive Pulmonary Disease

Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases

(2014) Katharine H. Abbott-Banner et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Emerging targets for novel therapy of asthma

(2013) William T Gerthoffer et al.   CURRENT OPINION IN PHARMACOLOGY

Transcriptome sequencing (RNA-Seq) of human endobronchial biopsies: asthmaversuscontrols

(2013) Ching Yong Yick et al.   EUROPEAN RESPIRATORY JOURNAL

New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders

(2013) Maliheh Safavi et al.   Expert Opinion on Drug Discovery

Phosphodiesterase-4 inhibitors: a review of current developments (2010 – 2012)

(2013) Amadeu Gavaldà et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

(2013) Lui G Franciosi et al.   Lancet Respiratory Medicine

Reduction in oral corticosteroid use in patients with severe allergic (IgE-mediated) asthma receiving omalizumab in a real-world setting

(2013) Gert-Jan Braunstahl et al.   Clinical and Translational Allergy

Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration

(2012) Koji Ochiai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective PDE inhibitors as novel treatments for respiratory diseases

(2012) Clive P Page et al.   CURRENT OPINION IN PHARMACOLOGY

Discovery of a novel orally active PDE-4 inhibitor effective in an ovalbumin-induced asthma murine model

(2012) Hyun Jeong Kwak et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues

(2011) Issaka Yougbare et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma

(2011) E. Chevalier et al.   EUROPEAN RESPIRATORY JOURNAL

ASP3258, an orally active potent phosphodiesterase 4 inhibitor with low emetic activity

(2011) Miki Kobayashi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

In Vivo Characterization of GSK256066, a High-Affinity Inhaled Phosphodiesterase 4 Inhibitor

(2011) A. T. Nials et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

β2-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D

(2011) Thomas Trian et al.   PLoS One

PDE4-inhibitors: A novel, targeted therapy for obstructive airways disease

(2011) Zuzana Diamant et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Phosphodiesterase 4B is essential for TH2-cell function and development of airway hyperresponsiveness in allergic asthma

(2010) S.-L. Catherine Jin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

(2009) Katharine H Banner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats

(2009) T. Wang et al.   EUROPEAN RESPIRATORY JOURNAL

Randomized, placebo-controlled study of a selective PDE4 inhibitor in the treatment of asthma

(2009) Susan Lu et al.   RESPIRATORY MEDICINE

PDE4 inhibitors: current status

(2008) D Spina   BRITISH JOURNAL OF PHARMACOLOGY

A Major Functional Role for Phosphodiesterase 4D5 in Human Airway Smooth Muscle Cells

(2007) Charlotte K. Billington et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY