Phosphodiesterase-4 inhibitors: a review of current developments (2010 – 2012)

Tetomilast: new promise for phosphodiesterase-4 inhibitors?

(2012) Stephen J Bickston et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Efficacy of apremilast in the treatment of moderate to severe psoriasis: a randomised controlled trial

(2012) Kim Papp et al.   LANCET

Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2

(2011) Jacob L. Nankervis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

GSK256066, an Exceptionally High-Affinity and Selective Inhibitor of Phosphodiesterase 4 Suitable for Administration by Inhalation: In Vitro, Kinetic, and In Vivo Characterization

(2011) C. J. Tralau-Stewart et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Water-soluble PDE4 inhibitors for the treatment of dry eye

(2010) Steven P. Govek et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

(2010) F. Mori et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration

(2009) Christopher J. Lunniss et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration

(2009) Michael D. Woodrow et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis

(2009) PH Schafer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs

(2009) Han-Ting Zhang   CURRENT PHARMACEUTICAL DESIGN

PDE4 inhibitors: a review of current developments (2005 – 2009)

(2009) Lluís Pagès et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Dual Inhibitors of Phosphodiesterase-4 and Serotonin Reuptake

(2009) John R. Cashman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors

(2008) J. Nicole Hamblin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice

(2008) Hitoshi Ichikawa et al.   INFLAMMATORY BOWEL DISEASES