β2-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

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Ca2+ homeostasis and structural and functional remodelling of airway smooth muscle in asthma

(2010) K. Mahn et al.   THORAX

Mechanism regulating proasthmatic effects of prolonged homologous β2-adrenergic receptor desensitization in airway smooth muscle

(2009) Gustavo Nino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-β1-stimulated fibroblasts

(2009) Shinsaku Togo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells

(2009) Megumi Goto et al.   CELLULAR IMMUNOLOGY

Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma

(2009) K. Mahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Steroids completely reverse albuterol-induced β 2 -adrenergic receptor tolerance in human small airways

(2008) Philip R. Cooper et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY