Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer’s disease (AD)

Nonpharmacological Treatment of Alzheimer Disease

(2017) Clive Ballard et al.   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders II: Alzheimers Disease

(2012) Miguel Divino da Rocha et al.   CNS & Neurological Disorders-Drug Targets

Solanezumab for the treatment of mild-to-moderate Alzheimer’s disease

(2012) Bruno P Imbimbo et al.   Expert Review of Clinical Immunology

Statins to treat Alzheimer’s disease: an incomplete story

(2012) Marwan N Sabbagh et al.   Expert Review of Neurotherapeutics

Immunotherapy for Alzheimer’s disease: from anti-β-amyloid to tau-based immunization strategies

(2012) Francesco Panza et al.   Immunotherapy

Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life

(2012) Danielle Swanson et al.   Advances in Nutrition

Tramiprosate in mild-to-moderate Alzheimer’s disease – a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)

(2011) Paul S. Aisen et al.   Archives of Medical Science

Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

(2011) H. Rheinallt Parri et al.   BIOCHEMICAL PHARMACOLOGY

Sortilin: An unusual suspect in cholesterol metabolism

(2011) Joseph B. Dubé et al.   BIOESSAYS

Managing Cognitive Dysfunction through the Continuum of Alzheimerʼs Disease

(2011) Julien Delrieu et al.   CNS DRUGS

γ-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes

(2011) Bruno P. Imbimbo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Current and Emerging Drug Treatment Options for Alzheimerʼs Disease

(2011) Nathan Herrmann et al.   DRUGS

The Role of Phytochemicals in the Treatment and Prevention of Dementia

(2011) Melanie-Jayne R. Howes et al.   DRUGS & AGING

Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before

(2011) Cesare Mancuso et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Metals in alzheimer's disease: a systemic perspective

(2011) Rosanna Squitti   Frontiers in Bioscience-Landmark

Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain

(2011) D. Allan Butterfield et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease

(2011) Maire E. Percy et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The role of metallobiology and amyloid-β peptides in Alzheimer’s disease

(2011) Blaine R. Roberts et al.   JOURNAL OF NEUROCHEMISTRY

Proteolytic processing of Alzheimer’s β-amyloid precursor protein

(2011) Han Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’

(2011) Rudy J Castellani et al.   JOURNAL OF PATHOLOGY

Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases: Beneficial Effect of Docosahexaenoic Acid on Cognitive Decline in Alzheimer’s Disease

(2011) Michio Hashimoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease

(2011) Jun Wang et al.   Molecular Neurodegeneration

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Development of subtype-selective oestrogen receptor-based therapeutics

(2011) Stefan Nilsson et al.   NATURE REVIEWS DRUG DISCOVERY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Statins in the treatment of Alzheimer disease

(2011) D. Larry Sparks   Nature Reviews Neurology

Cholesterol-independent neuroprotective and neurotoxic activities of statins: Perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders

(2011) D. Allan Butterfield et al.   PHARMACOLOGICAL RESEARCH

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

(2011) Yuhai Zhao et al.   PLoS One

DHA Supplemented in Peptamen Diet Offers No Advantage in Pathways to Amyloidosis: Is It Time to Evaluate Composite Lipid Diet?

(2011) Zareen Amtul et al.   PLoS One

Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1

(2011) Matthew A. Wozniak et al.   PLoS One

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer’s disease

(2011) Karim Bordji et al.   REVIEWS IN THE NEUROSCIENCES

Traditional Chinese medicines and Alzheimer’s disease

(2011) Tzong-Yuan Wu et al.   Taiwanese Journal of Obstetrics & Gynecology

Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia

(2011) Michael Ewers et al.   TRENDS IN NEUROSCIENCES

The roles of amyloid precursor protein (APP) in neurogenesis

(2011) Zhi-dong Zhou et al.   Cell Adhesion & Migration

Amyloid imaging in the differential diagnosis of dementia: review and potential clinical applications

(2011) Robert Laforce et al.   Alzheimers Research & Therapy

Goal-Oriented Cognitive Rehabilitation for People With Early-Stage Alzheimer Disease: A Single-Blind Randomized Controlled Trial of Clinical Efficacy

(2010) Linda Clare et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Are We Prepared to Deal With the Alzheimer's Disease Pandemic?

(2010) J L Holtzman   CLINICAL PHARMACOLOGY & THERAPEUTICS

Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease

(2010) Jian Guo Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DHA May Prevent Age-Related Dementia

(2010) Greg M. Cole et al.   JOURNAL OF NUTRITION

Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells

(2010) Walter J. Lukiw et al.   NEUROREPORT

Update on the use of memantine in Alzheimer’s disease

(2010) Rob Marum   Neuropsychiatric Disease and Treatment

Oral amyloid anti-aggregating agent ELND005 is measurable in CSF and brain of healthy adult men

(2009) Pamela Garzone et al.   Alzheimers & Dementia

Drug development for Alzheimer's disease: Where are we now and where are we headed?

(2009) Marwan N. Sabbagh   American Journal Geriatric Pharmacotherapy

Translational Medicine Lessons from Flurizan's Failure in Alzheimer's Disease (AD) Trial: Implication for Future Drug Discovery and Development for AD

(2009) Hong I. Wan et al.   CTS-Clinical and Translational Science

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lessons learned in the use of volumetric MRI in therapeutic trials in Alzheimer’s disease: The Alzhemedtm (Tramiprosate) experience

(2009) D. Saumier et al.   Journal of Nutrition Health & Aging

Metal sulfate-mediated induction of pathogenic genes and repression by phenyl butyl nitrone and Feralex-G

(2009) Theodore P.A. Kruck et al.   NEUROREPORT

HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signaling

(2009) James M. Hill et al.   NEUROREPORT

Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex

(2009) Prerna Sethi et al.   NEUROSCIENCE LETTERS

Toward Structural Elucidation of the γ-Secretase Complex

(2009) Huilin Li et al.   STRUCTURE

Emerging amyloid beta (Ab) peptide modulators for the treatment of Alzheimer's disease (AD)

(2008) Walter J Lukiw   EXPERT OPINION ON EMERGING DRUGS

An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells

(2008) Walter J. Lukiw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence supporting nutritional interventions for persons in early stage Alzheimer’s disease (AD)

(2008) S. C. Burgener et al.   Journal of Nutrition Health & Aging

Statins, incident Alzheimer disease, change in cognitive function, and neuropathology

(2008) Z. Arvanitakis et al.   NEUROLOGY

Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain

(2006) Catherine E. Creeley et al.   NEUROBIOLOGY OF AGING