Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiangyun Li, Jianbo Yu, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Cui Li, Yuting Li, Yanfang Zhang, Haibo Li
Summary: Sepsis-induced acute lung injury leads to oxidative stress, inflammation, apoptosis, and changes in Golgi morphology. Activating the HO-1 pathway can alleviate Golgi stress and oxidative stress, providing a therapeutic target for treating acute lung injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Hieronim Jakubowski
Summary: High-density lipoprotein (HDL) has cardio- and neuro-protective properties, which are mediated by paraoxonase 1 (PON1), an enzyme associated with a specific HDL subfraction. Reduced levels of PON1 activity, characterized by elevated levels of specific metabolites, are associated with cardiovascular and neurological abnormalities. Recent studies have highlighted the role of dysregulated proteostasis in the disease phenotypes associated with low PON1 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Nicole K. Campbell, Hannah K. Fitzgerald, Aisling Dunne
Summary: HO-1, known for its antioxidant properties, has also been shown to have anti-inflammatory effects, making it a potential treatment for chronic inflammatory and autoimmune diseases. Inducing HO-1 has therapeutic potential, but there are challenges to translating this treatment to clinical use.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chiara Caselli, Raffaele De Caterina, Rosetta Ragusa, Riccardo Liga, Alessia Gimelli, Arthur J. H. A. Scholte, Aldo Clerico, Juhani Knuuti, Danilo Neglia
Summary: The study aimed to evaluate the relationship between plasma HO-1 levels, clinical/molecular profiles, and coronary disease patterns in patients with chronic coronary syndromes (CCS). Results showed that patients with higher HO-1 levels were more often male, had higher BMI, and presented with a more diffuse but mainly non-obstructive coronary atherosclerosis, suggesting a potential protective role for the Nrf2/HO-1 pathway.
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Review
Biochemistry & Molecular Biology
Yi-Hsuan Wu, Hsi-Lung Hsieh
Summary: The heme oxygenase system, particularly HO-1 and HO-2, plays an important role in the nervous system. Dysregulation of HO-1 is associated with neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Alzheimer's disease is the principal cause of dementia and is associated with neurodegenerative disorders. Hericium erinaceus, a nutritional mushroom with important antioxidant effects, has shown significant therapeutic effects in a rat model of AD, reducing behavioral changes and hippocampal neuronal degeneration.
Review
Biochemistry & Molecular Biology
Laura Gomez-Virgilio, Alejandro Luarte, Daniela P. Ponce, Barbara A. Bruna, Maria Behrens
Summary: Among the proposed pathogenic mechanisms for Alzheimer's disease, increased oxidative stress appears to be a robust and early feature. Utilizing patient-derived peripheral cells may provide a more biologically relevant model for studying the disease. Analyzing olfactory neuronal precursors isolated non-invasively through NADH FLIM has the potential to reveal AD-related oxidative stress and accelerate the discovery of effective antioxidant therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ru-lan Zhang, Bing-xi Lei, Guo-yong Wu, Yuan-yuan Wang, Qi-hui Huang
Summary: This study demonstrates that berberine can protect neurons against A beta 25-35-induced neurotoxicity in HT22 cells by relieving oxidative stress and inhibiting the mitochondrial pathway of cellular apoptosis.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Royal Patel, Karamjeet Kaur, Shamsher Singh
Summary: Andrographolide (ANDRO) shows neuroprotective effects against ICV-STZ induced AD-like symptoms in rats, improving behavioral deficits and alterations in biochemical, neuroinflammatory mediators, and neurotransmitters in the hippocampus.
INFLAMMOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jia-Jing Lu, Ayitila Abudukeyoumu, Xing Zhang, Li-Bing Liu, Ming-Qing Li, Feng Xie
Summary: This review summarizes the different effects of HO-1 under normal and diseased conditions, with implications on the diagnosis and treatment of gynecological cancers, suggesting its potential role in cell proliferation, metastasis, immune regulation, and angiogenesis as an oncogene.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jung-Yeon Kim, Yongmin Choi, Jaechan Leem, Jeong Eun Song
Summary: Study shows that pharmacological induction of HO-1 can ameliorate cholestatic liver disease by reducing liver damage and cholestasis, suppressing oxidative stress, hepatocyte apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Thomas Bertrand, Ayda Tavitian, Julia M. Galindez, Vimal Kothari, Shrisha Mohit, Carmela Galindez, Adrienne Liberman, Judy Glass, Ana M. Velly, Mervyn Gornitsky, Karl Looper, Soham Rej, Hyman M. Schipper
Summary: This study found that higher levels of salivary HO-1 expression were detected in patients experiencing an acute psychotic episode compared to control participants, and this overexpression was positively associated with psychiatric symptom severity and disability. The results suggest that overexpression of HO-1 in saliva may serve as a potential biomarker for psychosis and should be explored further in larger clinical trials.
PSYCHIATRY RESEARCH
(2021)
Review
Immunology
Sen Yang, Jing Ouyang, Yanqiu Lu, Vijay Harypursat, Yaokai Chen
Summary: Iron metabolism is essential for the survival of humans and microorganisms, and heme oxygenase-1 (HO-1) plays a significant role in this process. Recent studies have shown that HO-1 has a dual role in tuberculosis, acting as both a cytoprotective molecule and potentially facilitating the survival and dissemination of Mycobacterium tuberculosis. This understanding of the interplay between HO-1, tuberculosis, and the host is crucial for the development of potential strategies to modulate HO-1 and iron metabolism.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Marzia Perluigi, Anna Picca, Elita Montanari, Riccardo Calvani, Federico Marini, Roberto Matassa, Antonella Tramutola, Alberto Villani, Giuseppe Familiari, Fabio Di Domenico, D. Allan Butterfield, Kenneth J. Oh, Emanuele Marzetti, Diletta Valentini, Eugenio Barone
Summary: The study found that nEVs isolated from DS children showed a significant increase in insulin resistance marker pIRS1(Ser636) and hyperactivation of the Akt/mTOR/p70S6K pathway downstream from IRS1, possibly driven by higher inhibition of PTEN. Additionally, high levels of pGSK3 beta(Ser9) were also observed. These alterations in the insulin-signaling/mTOR pathways are believed to be early events in the DS brain, contributing to the cognitive dysfunction and intellectual disability seen in this unique population.
ALZHEIMERS & DEMENTIA
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
D. Allan Butterfield, Eugenio Barone, Fabio Di Domenico, Marzia Perluigi
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Editorial Material
Cell Biology
Eugenio Barone
NEURAL REGENERATION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Cesare Mancuso
Summary: This article explores the role of the HO/BVR system in heme metabolism and discusses the neuroprotective potential of drugs targeting HO-1. However, there are currently no drugs available that specifically target HO-1 or BVR.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Article
Biochemistry & Molecular Biology
Sara Pagnotta, Antonella Tramutola, Eugenio Barone, Fabio Di Domenico, Valeria Pittala, Loredana Salerno, Valentina Folgiero, Matteo Caforio, Franco Locatelli, Stefania Petrini, D. Allan Butterfield, Marzia Perluigi
Summary: This study focuses on the role of BACH1/NRF2 ratio in the regulation of antioxidant response and its impact on patients with Down syndrome. The results show that overexpression of BACH1 disrupts the induction of antioxidant response genes, leading to oxidative damage accumulation. Additionally, administration of CAPE and VP961 promotes NRF2 nuclear translocation in cells from Down syndrome patients, improving antioxidant response.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Chiara Lanzillotta, Antonella Tramutola, Fabio Di Domenico, Bindu Paul, Solomon Snyder, D. Allan Butterfield, Marzia Perluigi, Joao Duarte, Eugenio Barone
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Fabio Di Domenico, Chiara Lanzillotta, Eugenio Barone, Antonella Tramutola, Marzia Perluigi
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Antonella Tramutola, Sara Pagnotta, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Francesco Pastore, Martina Battistoni, Raimondo Sollazzo, Pietro Renna, Fabiola Paciello, Domenica Donatella Li Puma, Eugenio Barone, Onur Dagliyan, Cristian Ripoli, Claudio Grassi
Summary: ADAM10 is a cell surface protease involved in the cleavage of membrane proteins. Dysregulation of ADAM10 has been linked to various pathological conditions, including AD. Researchers have designed a bioengineering strategy to control the cleavage activity of ADAM10, providing insights into AD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Chiara Urbinati, Chiara Lanzillotta, Livia Cosentino, Daniela Valenti, Maria Cristina Quattrini, Livia Di Crescenzo, Francesca Prestia, Donatella Pietraforte, Marzia Perluigi, Fabio Di Domenico, Rosa Anna Vacca, Bianca De Filippis
Summary: Metformin treatment can selectively correct cognitive flexibility defects, improve mitochondrial function, and inhibit oxidative stress in female mice with Rett syndrome (RTT). However, it does not affect the general health and motor skills of RTT mice.
Article
Biochemistry & Molecular Biology
Antonella Tramutola, Simona Lanzillotta, Giuseppe Aceto, Sara Pagnotta, Gabriele Ruffolo, Pierangelo Cifelli, Federico Marini, Cristian Ripoli, Eleonora Palma, Claudio Grassi, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
Summary: Down syndrome (DS) is associated with Alzheimer's disease (AD) and brain insulin resistance. The KYCCSRK peptide has shown potential for improving insulin signaling in DS and reducing AD-like neuropathology in mice.
Article
Biochemistry & Molecular Biology
Flavia Agata Cimini, Antonella Tramutola, Ilaria Barchetta, Valentina Ceccarelli, Elena Gangitano, Simona Lanzillotta, Chiara Lanzillotta, Maria Gisella Cavallo, Eugenio Barone
Summary: BVRA protein levels can change dynamically in response to insulin and are greater in individuals with lower insulin sensitivity, indicating a correlation with insulin resistance and secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Endocrinology & Metabolism
Joao Duarte, Fernanda De Felice, Eugenio Barone, Elizabeth Rhea
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Eugenio Barone
FREE RADICAL BIOLOGY AND MEDICINE
(2022)