期刊
NEUROREPORT
卷 19, 期 2, 页码 245-249出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3282f4cb7e
关键词
aluminum; Alzheimer's disease; ascorbate; cyclooxygenase-2; cytosolic phospholipase A(2); Feralex-G; folate; human neural cells; inflammation; iron; phenyl butyl nitrone; reactive oxygen species; sulfates
资金
- NIA NIH HHS [AG18031] Funding Source: Medline
Neurotoxic metal-induced oxidative damage to nervous tissue has been implicated in several progressive neurodegenerative disorders including Alzheimer's disease. In this study, using human brain cells in primary culture, the quenching of metal sulfate-induced reactive oxygen species (ROS) and ROS-sensitive gene expression was studied using the antioxidants ascorbate, folic acid, phenyl butyl nitrone and the chelators desferrioxamine and Feralex-G. Antioxidants ascorbate, folic acid, phenyl butyl nitrone, desferrioxamine or Feralex-G were found to quench ROS and cPLA(2) and COX-2 gene induction to various degrees, and a synergism was observed when certain combinations of them were used. These findings support the idea that specific antioxidants and metal ion chelators when used together can effectively and synergistically quench ROS-mediated induction of pathogenic gene expression.
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