The role of drug metabolizing enzymes in clearance

The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification

(2013) Andrew Rowland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies

(2013) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and -2Bs in Human Liver Using NanoUPLC–MS/MS with Selected Reaction Monitoring

(2013) John K. Fallon et al.   JOURNAL OF PROTEOME RESEARCH

Predicting Intrinsic Clearance for Drugs and Drug Candidates Metabolized by Aldehyde Oxidase

(2013) Jeffrey P. Jones et al.   MOLECULAR PHARMACEUTICS

Albumin Stimulates the Activity of the Human UDP-Glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the Effects Are Enzyme and Substrate Dependent

(2013) Nenad Manevski et al.   PLoS One

The Gate That Governs Sulfotransferase Selectivity

(2012) Ian Cook et al.   BIOCHEMISTRY

Medicinal chemistry approaches to avoid aldehyde oxidase metabolism

(2012) David C. Pryde et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression

(2012) Mami Kurosaki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures andin silicomodeling

(2012) Dong Dong et al.   DRUG METABOLISM REVIEWS

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

(2012) Li Di et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Strategies for a comprehensive understanding of metabolism by aldehyde oxidase

(2012) James Matthew Hutzler et al.   Expert Opinion on Drug Metabolism & Toxicology

The role of aldehyde oxidase in drug metabolism

(2012) Enrico Garattini et al.   Expert Opinion on Drug Metabolism & Toxicology

Crystal structures of human sulfotransferases: insights into the mechanisms of action and substrate selectivity

(2012) Dong Dong et al.   Expert Opinion on Drug Metabolism & Toxicology

The First Mammalian Aldehyde Oxidase Crystal Structure

(2012) Catarina Coelho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Characterization of Human Cytochrome P450 2C19

(2012) R. Leila Reynald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interspecies variation in the metabolism of zoniporide by aldehyde oxidase

(2012) Deepak Dalvie et al.   XENOBIOTICA

Protein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities

(2012) Yuichiro Sato et al.   XENOBIOTICA

Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches

(2012) Chitra Sridar et al.   XENOBIOTICA

Quantification of Human Uridine-Diphosphate Glucuronosyl Transferase 1A Isoforms in Liver, Intestine, and Kidney Using Nanobore Liquid Chromatography–Tandem Mass Spectrometry

(2011) David E. Harbourt et al.   ANALYTICAL CHEMISTRY

Can pharmacogenomics improve malaria drug policy?

(2011) Mary Roederer et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Effects of Ketamine on Human UDP-Glucuronosyltransferases In Vitro Predict Potential Drug-Drug Interactions Arising from Ketamine Inhibition of Codeine and Morphine Glucuronidation

(2011) V. Uchaipichat et al.   DRUG METABOLISM AND DISPOSITION

Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data

(2011) H. E. Cubitt et al.   DRUG METABOLISM AND DISPOSITION

Inhibition of Human Liver Aldehyde Oxidase: Implications for Potential Drug-Drug Interactions

(2011) J. T. Barr et al.   DRUG METABOLISM AND DISPOSITION

Increasing recognition of the importance of aldehyde oxidase in drug development and discovery

(2011) Enrico Garattini et al.   DRUG METABOLISM REVIEWS

Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes

(2011) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Case report of extensive metabolism by aldehyde oxidase in humans: Pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans

(2011) Takafumi Akabane et al.   XENOBIOTICA

Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites

(2010) W. W. Wang et al.   DRUG METABOLISM AND DISPOSITION

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

(2010) David C. Pryde et al.   JOURNAL OF MEDICINAL CHEMISTRY

Determination of propofol UDP-glucuronosyltransferase (UGT) activities in hepatic microsomes from different species by UFLC–ESI-MS

(2010) Si-Cheng Liang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

In Vitro-In Vivo Extrapolation Predicts Drug-Drug Interactions Arising from Inhibition of Codeine Glucuronidation by Dextropropoxyphene, Fluconazole, Ketoconazole, and Methadone in Humans

(2010) P. Raungrut et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

(2010) David Hallifax et al.   PHARMACEUTICAL RESEARCH

In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor

(2010) X Zhang et al.   PHARMACOGENOMICS JOURNAL

Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development

(2009) Masato Chiba et al.   AAPS Journal

Prediction of Biliary Excretion in Rats and Humans Using Molecular Weight and Quantitative Structure–Pharmacokinetic Relationships

(2009) Xinning Yang et al.   AAPS Journal

Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters

(2009) A. Rowland et al.   DRUG METABOLISM AND DISPOSITION

Sulfation of O-Demethyl Apixaban: Enzyme Identification and Species Comparison

(2009) L. Wang et al.   DRUG METABOLISM AND DISPOSITION

Quantitative Evaluation of the Expression and Activity of Five Major Sulfotransferases (SULTs) in Human Tissues: The SULT "Pie"

(2009) Z. Riches et al.   DRUG METABOLISM AND DISPOSITION

The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping andin vitro–in vivoextrapolation of drug clearance and drug-drug interaction potential

(2009) John O. Miners et al.   DRUG METABOLISM REVIEWS

Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

(2009) Michael H. Court   DRUG METABOLISM REVIEWS

Ethnic differences in drug metabolism and toxicity from chemotherapy

(2009) Viet Hong Phan et al.   Expert Opinion on Drug Metabolism & Toxicology

Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches

(2009) Natilie A. Hosea et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Impact of Hepatic Uptake Transporters on Pharmacokinetics and Drug−Drug Interactions: Use of Assays and Models for Decision Making in the Pharmaceutical Industry

(2009) Mathew G. Soars et al.   MOLECULAR PHARMACEUTICS

Relative Importance of Intestinal and Hepatic Glucuronidation—Impact on the Prediction of Drug Clearance

(2009) Helen E. Cubitt et al.   PHARMACEUTICAL RESEARCH

Assessment of cryopreserved human hepatocytes as a model system to investigate sulfation and glucuronidation and to evaluate inhibitors of drug conjugation

(2009) Z. Riches et al.   XENOBIOTICA

Structure, Function and Polymorphism of Human Cytosolic Sulfotransferases

(2008) Yong Li et al.   CURRENT DRUG METABOLISM

Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

(2008) P. J. Kilford et al.   DRUG METABOLISM AND DISPOSITION

In Silico Modeling of Nonspecific Binding to Human Liver Microsomes

(2008) H. Gao et al.   DRUG METABOLISM AND DISPOSITION

Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data

(2008) P. J. Kilford et al.   DRUG METABOLISM AND DISPOSITION

Effect of the β-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases

(2008) Lauren Oleson et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY