Increasing the success rate of lantibiotic drug discovery by Synthetic Biology

A High-Throughput Screen Identifies a New Natural Product with Broad-Spectrum Antibacterial Activity

(2012) Patrick Ymele-Leki et al.   PLoS One

Synergistic Drug Combinations for Tuberculosis Therapy Identified by a Novel High-Throughput Screen

(2011) Santiago Ramón-García et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ecology and Evolution as Targets: the Need for Novel Eco-Evo Drugs and Strategies To Fight Antibiotic Resistance

(2011) Fernando Baquero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial Display and Screening of Posttranslationally Thioether-Stabilized Peptides

(2011) Tjibbe Bosma et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Leader Peptide-Directed Processing of Labyrinthopeptin A2 Precursor Peptide by the Modifying Enzyme LabKC

(2011) Wolfgang M. Müller et al.   BIOCHEMISTRY

Artificial lantipeptides from in vitro translations

(2011) Florian P. Seebeck et al.   CHEMICAL COMMUNICATIONS

Heterologous Expression, Biosynthesis, and Mutagenesis of Type II Lantibiotics from Bacillus licheniformis in Escherichia coli

(2011) Tânia Caetano et al.   CHEMISTRY & BIOLOGY

Are Bacteriocins Underexploited? NOVEL Applications for OLD Antimicrobials

(2011) Manuel Montalban-Lopez et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Creeping baselines and adaptive resistance to antibiotics

(2011) Lucía Fernández et al.   DRUG RESISTANCE UPDATES

Discovery and development of lantibiotics; antimicrobial agents that have significant potential for medical application

(2011) Mohammed M Al-Mahrous et al.   Expert Opinion on Drug Discovery

Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans

(2011) Auke Johan van Heel et al.   Expert Opinion on Drug Metabolism & Toxicology

Bacteriophage therapy: potential uses in the control of antibiotic-resistant pathogens

(2011) Ben Burrowes et al.   Expert Review of Anti-Infective Therapy

Mechanisms of in-vitro-selected daptomycin-non-susceptibility in Staphylococcus aureus

(2011) Diixa Patel et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Solid Supported Chemical Syntheses of Both Components of the Lantibiotic Lacticin 3147

(2011) Wei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nine Post-translational Modifications during the Biosynthesis of Cinnamycin

(2011) Ayşe Ökesli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Current Concepts in Antimicrobial Therapy Against Select Gram-Positive Organisms: Methicillin-ResistantStaphylococcus aureus, Penicillin-Resistant Pneumococci, and Vancomycin-Resistant Enterococci

(2011) Ana Maria Rivera et al.   MAYO CLINIC PROCEEDINGS

A mass spectrometry–guided genome mining approach for natural product peptidogenomics

(2011) Roland D Kersten et al.   Nature Chemical Biology

The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides

(2011) Alethea B. Tabor   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of Peptides Containing Overlapping Lanthionine Bridges on the Solid Phase: An Analogue of Rings D and E of the Lantibiotic Nisin

(2011) Begum Mothia et al.   ORGANIC LETTERS

Synthetic Biology: Integrated Gene Circuits

(2011) N. Nandagopal et al.   SCIENCE

Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics

(2010) Kathrin Meindl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Production of a Class II Two-Component Lantibiotic of Streptococcus pneumoniae Using the Class I Nisin Synthetic Machinery and Leader Sequence

(2010) J. A. Majchrzykiewicz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Requirements of the Engineered Leader Peptide of Nisin for Inducing Modification, Export, and Cleavage

(2010) Annechien Plat et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria

(2010) Alan J Marsh et al.   BMC GENOMICS

BACTIBASE second release: a database and tool platform for bacteriocin characterization

(2010) Riadh Hammami et al.   BMC MICROBIOLOGY

Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms

(2010) Yi-Ming Chiang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Genome mining for ribosomally synthesized natural products

(2010) Juan E Velásquez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fundamental functionality: recent developments in understanding the structure–activity relationships of lantibiotic peptides

(2010) Avena C Ross et al.   JOURNAL OF ANTIBIOTICS

Role of Antimicrobial Selective Pressure and Secondary Factors on Antimicrobial Resistance Prevalence inEscherichia colifrom Food-Producing Animals in Japan

(2010) Kazuki Harada et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Production of Lantipeptides inEscherichia coli

(2010) Yanxiang Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Community-associated meticillin-resistant Staphylococcus aureus

(2010) Frank R DeLeo et al.   LANCET

BAGEL2: mining for bacteriocins in genomic data

(2010) Anne de Jong et al.   NUCLEIC ACIDS RESEARCH

Methicillin Resistant Staphylococcus aureus ST398 in Veal Calf Farming: Human MRSA Carriage Related with Animal Antimicrobial Usage and Farm Hygiene

(2010) Haitske Graveland et al.   PLoS One

Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes

(2010) L. C. Foulston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile

(2010) M. C. Rea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

(2010) Yuki Goto et al.   PLOS BIOLOGY

Identification of a Novel Two-Peptide Lantibiotic, Lichenicidin, following Rational Genome Mining for LanM Proteins

(2009) M. Begley et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Investigation of the Substrate Specificity of Lacticin 481 Synthetase by Using Nonproteinogenic Amino Acids

(2009) Matthew R. Levengood et al.   CHEMBIOCHEM

Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides

(2009) Yuki Goto et al.   CHEMICAL COMMUNICATIONS

Lantibiotics: Mode of Action, Biosynthesis and Bioengineering

(2009) G. Bierbaum et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

5 Years of Experience Implementing a Methicillin-Resistant Staphylococcus aureus Search and Destroy Policy at the Largest University Medical Center in the Netherlands

(2009) Margreet C. Vos et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

A comparison of the activities of lacticin 3147 and nisin against drug-resistant Staphylococcus aureus and Enterococcus species

(2009) C. Piper et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Production of the Bsa Lantibiotic by Community-Acquired Staphylococcus aureus Strains

(2009) K. M. Daly et al.   JOURNAL OF BACTERIOLOGY

Lantibiotics: Diverse activities and unique modes of action

(2009) Sikder M. Asaduzzaman et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

In Vitro Mutasynthesis of Lantibiotic Analogues Containing Nonproteinogenic Amino Acids

(2009) Matthew R. Levengood et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system

(2009) Steven Boakes et al.   MOLECULAR MICROBIOLOGY

Cross-immunity and immune mimicry as mechanisms of resistance to the lantibiotic lacticin 3147

(2009) Lorraine A. Draper et al.   MOLECULAR MICROBIOLOGY

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

Synthesis and Biological Activity of Oxa-Lacticin A2, a Lantibiotic Analogue with Sulfur Replaced by Oxygen

(2009) Hongqiang Liu et al.   ORGANIC LETTERS

Production of the Novel Two-Peptide Lantibiotic Lichenicidin by Bacillus licheniformis DSM 13

(2009) Jasmin Dischinger et al.   PLoS One

Manipulation of charged residues within the two-peptide lantibiotic lacticin 3147

(2009) Lucy H. Deegan et al.   Microbial Biotechnology

The Vancomycin−Nisin(1−12) Hybrid Restores Activity against Vancomycin Resistant Enterococci†

(2008) Christopher J. Arnusch et al.   BIOCHEMISTRY

Use of lantibiotic synthetases for the preparation of bioactive constrained peptides

(2008) Matthew R. Levengood et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Determining the Structure and Mode of Action of Microbisporicin, a Potent Lantibiotic Active Against Multiresistant Pathogens

(2008) Franca Castiglione et al.   CHEMISTRY & BIOLOGY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

N-terminal acetylation in paenibacillin, a novel lantibiotic

(2008) Zengguo He et al.   FEBS LETTERS

The generation of nisin variants with enhanced activity against specific Gram-positive pathogens

(2008) Des Field et al.   MOLECULAR MICROBIOLOGY

Whole-cell matrix-assisted laser desorption/ionization mass spectrometry for rapid identification of bacteriocin/lantibiotic-producing bacteria

(2008) Torsten Stein   RAPID COMMUNICATIONS IN MASS SPECTROMETRY