Ecology and Evolution as Targets: the Need for Novel Eco-Evo Drugs and Strategies To Fight Antibiotic Resistance

High Frequency of Antimicrobial Drug Resistance of Diarrheagenic Escherichia coli in Infants in Peru

(2018) Theresa J. Ochoa et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Update on the ongoing outbreak of haemolytic uraemic syndrome due to Shiga toxin-producing Escherichia coli (STEC) serotype O104, Germany, May 2011

(2017) M Askar et al.   Eurosurveillance

Effect of recA inactivation on mutagenesis of Escherichia coli exposed to sublethal concentrations of antimicrobials

(2011) T. D. Thi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Human and Swine Hosts Share Vancomycin-Resistant Enterococcus faecium CC17 and CC5 and Enterococcus faecalis CC2 Clonal Clusters Harboring Tn1546 on Indistinguishable Plasmids

(2011) A. R. Freitas et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery

(2011) H. U. Kim et al.   Molecular Systems Biology

The Genomic Enzymology of Antibiotic Resistance

(2010) Mariya Morar et al.   Annual Review of Genetics

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Discovery and Characterization of Inhibitors of Pseudomonas aeruginosa Type III Secretion

(2010) D. Aiello et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Improved network performance via antagonism: From synthetic rescues to multi-drug combinations

(2010) Adilson E. Motter   BIOESSAYS

Q&A: Antibiotic resistance: where does it come from and what can we do about it?

(2010) Gerard D Wright   BMC BIOLOGY

Antibacterials from the Sea

(2010) Chambers C. Hughes et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Impact of Vaccination on Rhinosinusitis and Otitis Media

(2010) Michael S. Benninger et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Curing the Plasmid pXO2 from Bacillus anthracis A16 Using Plasmid Incompatibility

(2010) Huagui Wang et al.   CURRENT MICROBIOLOGY

Antivirulence drugs to target bacterial secretion systems

(2010) Christian Baron   CURRENT OPINION IN MICROBIOLOGY

Recent advances in antiretroviral drugs

(2010) Raktim Kumar Ghosh et al.   EXPERT OPINION ON PHARMACOTHERAPY

AnIn VivoHigh-Throughput Screening Approach Targeting the Type IV Secretion System Component VirB8 Identified Inhibitors ofBrucella abortus2308 Proliferation

(2010) Athanasios Paschos et al.   INFECTION AND IMMUNITY

Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain

(2010) B. A. Rogers et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Predicting Plasmid Promiscuity Based on Genomic Signature

(2010) H. Suzuki et al.   JOURNAL OF BACTERIOLOGY

Mobile DNA can drive lineage extinction in prokaryotic populations

(2010) D. J. RANKIN et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene InhibitBurkholderia cepaciaComplex

(2010) David E. Greenberg et al.   JOURNAL OF INFECTIOUS DISEASES

Mobility of Plasmids

(2010) C. Smillie et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

(2010) Michael A. Kohanski et al.   MOLECULAR CELL

The σE stress response is required for stress-induced mutation and amplification in Escherichia coli

(2010) Janet L. Gibson et al.   MOLECULAR MICROBIOLOGY

Topical immunization strategies

(2010) C Czerkinsky et al.   Mucosal Immunology

Multilevel and kin selection in a connected world

(2010) Michael J. Wade et al.   NATURE

In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect

(2010) Thomas Bjarnsholt et al.   Nature Protocols

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow

(2010) Rachel A. F. Wozniak et al.   NATURE REVIEWS MICROBIOLOGY

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Modulation of natural immunity in the gut by Escherichia coli strain Nissle 1917

(2010) Ilja Trebichavsky et al.   NUTRITION REVIEWS

Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands

(2010) David Deniaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pharmacogenomic strategies against microbial resistance: from bright to bleak to innovative

(2010) Thomas Dandekar et al.   PHARMACOGENOMICS

Tracking Acquired Antibiotic Resistance in Commensal Bacteria of Galápagos Land Iguanas: No Man, No Resistance

(2010) Maria Cristina Thaller et al.   PLoS One

Molecular Characterisation of Trimethoprim Resistance in Escherichia coli and Klebsiella pneumoniae during a Two Year Intervention on Trimethoprim Use

(2010) Alma Brolund et al.   PLoS One

Blueprint for antimicrobial hit discovery targeting metabolic networks

(2010) Y. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of recombination on bacterial evolution

(2010) Xavier Didelot et al.   TRENDS IN MICROBIOLOGY

Modelling the effect of conjugate vaccines in pneumococcal disease: Cohort or population models?

(2010) Baudouin Standaert et al.   VACCINE

Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli

(2010) Tobias Dörr et al.   PLOS BIOLOGY

Optimal Drug Synergy in Antimicrobial Treatments

(2010) Joseph Peter Torella et al.   PLoS Computational Biology

A MATE-Family Efflux Pump Rescues the Escherichia coli 8-Oxoguanine-Repair-Deficient Mutator Phenotype and Protects Against H2O2 Killing

(2010) Javier R. Guelfo et al.   PLoS Genetics

Evolutionary Trajectories of Beta-Lactamase CTX-M-1 Cluster Enzymes: Predicting Antibiotic Resistance

(2010) Ângela Novais et al.   PLoS Pathogens

Quorum Sensing Inhibition Selects for Virulence and Cooperation in Pseudomonas aeruginosa

(2010) Thilo Köhler et al.   PLoS Pathogens

Effect of Subinhibitory Concentrations of Antibiotics on Intrachromosomal Homologous Recombination in Escherichia coli

(2009) E. Lopez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Resistance Plasmid Families in Enterobacteriaceae

(2009) A. Carattoli   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Escherichia coli genes affecting recipient ability in plasmid conjugation: Are there any?

(2009) Daniel Pérez-Mendoza et al.   BMC GENOMICS

Neuartige Impfstoffe

(2009) A. Wack et al.   Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz

Making Sense of Antisense in Antibiotic Drug Discovery

(2009) Gerard D. Wright   Cell Host & Microbe

Antibiotic Resistance in Bacteria: Novel Metalloenzyme Inhibitors

(2009) Sung-Kun Kim et al.   Chemical Biology & Drug Design

Environmental stress and evolvability in microbial systems

(2009) F. Baquero   CLINICAL MICROBIOLOGY AND INFECTION

Horizontal Gene Transfer of the Secretome Drives the Evolution of Bacterial Cooperation and Virulence

(2009) Teresa Nogueira et al.   CURRENT BIOLOGY

Productive steps toward an antimicrobial targeting virulence

(2009) Amy K Barczak et al.   CURRENT OPINION IN MICROBIOLOGY

Role of reactive oxygen species in antibiotic action and resistance

(2009) Daniel J Dwyer et al.   CURRENT OPINION IN MICROBIOLOGY

Cationic phosphorodiamidate morpholino oligomers efficiently prevent growth of Escherichia coli in vitro and in vivo

(2009) Brett L. Mellbye et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Functional relationship between bacterial cell density and the efficacy of antibiotics

(2009) K. I. Udekwu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Little evidence for reversibility of trimethoprim resistance after a drastic reduction in trimethoprim use

(2009) M. Sundqvist et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Optimal control of epidemics in metapopulations

(2009) R. E. Rowthorn et al.   Journal of the Royal Society Interface

Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

(2009) Janice Sufrin et al.   Marine Drugs

An SOS Inhibitor that Binds to Free RecA Protein: The PsiB Protein

(2009) Vessela Petrova et al.   MOLECULAR CELL

NovelEscherichia coliRF1 mutants with decreased translation termination activity and increased sensitivity to the cytotoxic effect of the bacterial toxins Kid and RelE

(2009) Elizabeth Diago-Navarro et al.   MOLECULAR MICROBIOLOGY

Social evolution in micro-organisms and a Trojan horse approach to medical intervention strategies

(2009) S. P. Brown et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A toxin–antitoxin module as a target for antimicrobial development

(2009) Virginia S. Lioy et al.   PLASMID

Genetic Architecture of Intrinsic Antibiotic Susceptibility

(2009) Hany S. Girgis et al.   PLoS One

Network analyses structure genetic diversity in independent genetic worlds

(2009) S. Halary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

(2009) T. K. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oscillations in continuous culture populations of Streptococcus pneumoniae: population dynamics and the evolution of clonal suicide

(2009) O. E Cornejo et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora

(2009) M. O. A. Sommer et al.   SCIENCE

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Predictions: evolutionary trajectories and planet medicine

(2009) Fernando Baquero   Microbial Biotechnology

Evidence for Different Pathways during Horizontal Gene Transfer in Competent Bacillus subtilis Cells

(2009) Dawit Kidane et al.   PLoS Genetics

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Prevalence and clonality of extended-spectrum β-lactamases in Asia

(2008) P.M. Hawkey   CLINICAL MICROBIOLOGY AND INFECTION

Antibiotics and antibiotic resistance in water environments

(2008) Fernando Baquero et al.   CURRENT OPINION IN BIOTECHNOLOGY

Host-bacterial coevolution and the search for new drug targets

(2008) Jesse Zaneveld et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Exposing plasmids as the Achilles’ heel of drug-resistant bacteria

(2008) Julia J Williams et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram-negative bacteria

(2008) P. Keyser et al.   JOURNAL OF INTERNAL MEDICINE

Predictable and unpredictable evolution of antibiotic resistance

(2008) P. Courvalin   JOURNAL OF INTERNAL MEDICINE

Curing of four different plasmids inYersinia pestisusing plasmid incompatibility

(2008) B. Ni et al.   LETTERS IN APPLIED MICROBIOLOGY

New trends in pharmacogenomic strategies against resistance development in microbial infections

(2008) Knut Ohlsen et al.   PHARMACOGENOMICS

Why is entry exclusion an essential feature of conjugative plasmids?

(2008) M. Pilar Garcillán-Barcia et al.   PLASMID

The Neglected Intrinsic Resistome of Bacterial Pathogens

(2008) Alicia Fajardo et al.   PLoS One

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

(2008) Luciano A. Marraffini et al.   SCIENCE

Targeting QseC Signaling and Virulence for Antibiotic Development

(2008) D. A. Rasko et al.   SCIENCE

Network risk management using attacker profiling

(2008) Ram Dantu et al.   Security and Communication Networks

CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaea

(2007) Rotem Sorek et al.   NATURE REVIEWS MICROBIOLOGY