期刊
ORGANIC LETTERS
卷 13, 期 16, 页码 4216-4219出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol201548m
关键词
-
资金
- Engineering and Physical Sciences Research Council (EPSRC)
- Novacta Biosystems Ltd.
A methodology for the solid-phase synthesis of the overlapping lanthionine bridges found in many lantibiotics has been developed. A novel Teoc/TMSE-protected lanthionine derivative has been synthesized, and this lanthionine, and an Aloc/allyl-protected lanthionine derivative, have been incorporated into a linear peptide using solid-phase peptide synthesis. Selective deprotection of the silyl protecting groups, followed by sequential cyclization, deprotection of the allyl protecting groups, and further cyclization, enabled the regloselective formation of an analogue of rings D and E of nisin.
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