An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer: Figure 1.

Pathogenic and Protective Roles of MyD88 in Leukocytes and Epithelial Cells in Mouse Models of Inflammatory Bowel Disease

(2010) Mark J. Asquith et al.   GASTROENTEROLOGY

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

(2010) Rosalba Salcedo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ERK activation drives intestinal tumorigenesis in Apcmin/+ mice

(2010) Sung Hee Lee et al.   NATURE MEDICINE

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors

(2009) Masayuki Fukata et al.   INFLAMMATORY BOWEL DISEASES

Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis

(2009) Jae-Young Kim et al.   PLoS One

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

(2009) Joshua M. Uronis et al.   PLoS One

Innate immune signalling at intestinal mucosal surfaces: a fine line between host protection and destruction

(2008) Elke Cario   CURRENT OPINION IN GASTROENTEROLOGY

Microbial Influences in Inflammatory Bowel Diseases

(2008) R. Balfour Sartor   GASTROENTEROLOGY

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

Interleukin-1 Receptor Signaling Protects Mice from Lethal Intestinal Damage Caused by the Attaching and Effacing Pathogen Citrobacter rodentium

(2008) S. L. Lebeis et al.   INFECTION AND IMMUNITY

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis

(2007) D. L. Gibson et al.   CELLULAR MICROBIOLOGY