标题
Anti-angiogenic drug discovery: lessons from the past and thoughts for the future
作者
关键词
-
出版物
Expert Opinion on Drug Discovery
Volume 7, Issue 8, Pages 723-743
出版商
Informa Healthcare
发表日期
2012-06-22
DOI
10.1517/17460441.2012.695774
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Clinical outcomes in bevacizumab (BV)-treated patients (pts) with metastatic colorectal cancer (mCRC): Results from ARIES observational cohort study (OCS) and confirmation of BRiTE data on BV beyond progression (BBP).
- (2017) A. L. Cohn et al. JOURNAL OF CLINICAL ONCOLOGY
- Hypertension (HTN) and proteinuria (PTN) as biomarkers of efficacy in antiangiogenic therapy for metastatic colorectal cancer (mCRC).
- (2017) Y. K. Zee et al. JOURNAL OF CLINICAL ONCOLOGY
- High-dose bevacizumab in the treatment of patients with advanced clear cell renal carcinoma (RCC): A Sarah Cannon Research Institute phase II trial.
- (2017) A. A. Meluch et al. JOURNAL OF CLINICAL ONCOLOGY
- Using bevacizumab to treat metastatic cancer: UK consensus guidelines
- (2014) D Miles et al. BRITISH JOURNAL OF HOSPITAL MEDICINE
- Sunitinib: the First to Arrive at First-Line Metastatic Renal Cell Carcinoma
- (2012) Sergio Vázquez et al. ADVANCES IN THERAPY
- Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy: Implications for Scheduling of Anti-Angiogenic Drugs
- (2012) Astrid A.M. Van der Veldt et al. CANCER CELL
- Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy
- (2012) C. S. F. Wong et al. CANCER RESEARCH
- Is the toxicity of anti-angiogenic drugs predictive of outcome? A review of hypertension and proteinuria as biomarkers of response to anti-angiogenic therapy
- (2012) Laura Horsley et al. Expert Opinion on Drug Metabolism & Toxicology
- Targeted therapy of hepatocellular carcinoma: Present and future
- (2012) Stephen L Chan et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Tumor Cell Plasticity and Angiogenesis in Human Melanomas
- (2012) Daniela Mihic-Probst et al. PLoS One
- Effect of Angiogenesis Inhibitor Bevacizumab on Survival in Patients with Cancer: A Meta-Analysis of the Published Literature
- (2012) Yuan Su et al. PLoS One
- Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study
- (2011) C. Bokemeyer et al. ANNALS OF ONCOLOGY
- A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer
- (2011) M. Reck et al. ANNALS OF ONCOLOGY
- Signal transduction by vascular endothelial growth factor receptors
- (2011) Sina Koch et al. BIOCHEMICAL JOURNAL
- The angiogenic process as a therapeutic target in cancer
- (2011) Esther M. Bridges et al. BIOCHEMICAL PHARMACOLOGY
- Severe clinical toxicities are correlated with survival in patients with advanced renal cell carcinoma treated with sunitinib and sorafenib
- (2011) F Di Fiore et al. BRITISH JOURNAL OF CANCER
- Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of "Rebound" Revascularization as Mode of Escape
- (2011) E. di Tomaso et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Matrix metalloproteinases in tumorigenesis: an evolving paradigm
- (2011) Hui Hua et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Impact of Exploratory Biomarkers on the Treatment Effect of Bevacizumab in Metastatic Breast Cancer
- (2011) A. M. Jubb et al. CLINICAL CANCER RESEARCH
- Appropriate end-points for right results in the age of antiangiogenic agents: Future options for phase II trials in patients with recurrent glioblastoma
- (2011) A.A. Brandes et al. EUROPEAN JOURNAL OF CANCER
- Risk of high-grade bleeding in patients with cancer treated with bevacizumab: a meta-analysis of randomized controlled trials
- (2011) Xiao Feng Hang et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Clinical end points in recurrent glioblastoma: are antiangiogenic agents friend or foe?
- (2011) Enrico Franceschi et al. Expert Review of Anticancer Therapy
- Emerging paradigms and questions on pro-angiogenic bone marrow-derived myelomonocytic cells
- (2011) Julien Laurent et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
- RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative, Locally Recurrent or Metastatic Breast Cancer
- (2011) Nicholas J. Robert et al. JOURNAL OF CLINICAL ONCOLOGY
- Cetuximab Plus Irinotecan, Fluorouracil, and Leucovorin As First-Line Treatment for Metastatic Colorectal Cancer: Updated Analysis of Overall Survival According to Tumor KRAS and BRAF Mutation Status
- (2011) Eric Van Cutsem et al. JOURNAL OF CLINICAL ONCOLOGY
- Clinical significance of vasculogenic mimicry in human gliomas
- (2011) Xiao-mei Liu et al. JOURNAL OF NEURO-ONCOLOGY
- Advanced or metastatic gastrointestinal stromal tumors: Systemic treatment options
- (2011) Megan V. Caram et al. JOURNAL OF SURGICAL ONCOLOGY
- Hypertension as a Biomarker of Efficacy in Patients With Metastatic Renal Cell Carcinoma Treated With Sunitinib
- (2011) B. I. Rini et al. JNCI-Journal of the National Cancer Institute
- A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Paclitaxel-Carboplatin Alone or with Endostar for Advanced Non-small Cell Lung Cancer
- (2011) Baohui Han et al. Journal of Thoracic Oncology
- Vascular endothelial growth factors and receptors: Anti-angiogenic therapy in the treatment of cancer
- (2011) Sònia Tugues et al. MOLECULAR ASPECTS OF MEDICINE
- Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth
- (2011) F. M. Yakes et al. MOLECULAR CANCER THERAPEUTICS
- Blood vessel maturation, vascular phenotype and angiogenic potential in malignant melanoma: One step forward for overcoming anti-angiogenic drug resistance?
- (2011) Iris Helfrich et al. Molecular Oncology
- Tumor angiogenesis: molecular pathways and therapeutic targets
- (2011) Sara M Weis et al. NATURE MEDICINE
- Antiangiogenic therapy: impact on invasion, disease progression and metastasis
- (2011) John M. L. Ebos et al. Nature Reviews Clinical Oncology
- Clinical trial end points for high-grade glioma: the evolving landscape
- (2011) D. A. Reardon et al. NEURO-ONCOLOGY
- Sunitinib Malate for the Treatment of Pancreatic Neuroendocrine Tumors
- (2011) Eric Raymond et al. NEW ENGLAND JOURNAL OF MEDICINE
- Identification and angiogenic role of the novel tumor endothelial marker CLEC14A
- (2011) M Mura et al. ONCOGENE
- Normalization of the Vasculature for Treatment of Cancer and Other Diseases
- (2011) Shom Goel et al. PHYSIOLOGICAL REVIEWS
- Functional and Structural Characteristics of Tumor Angiogenesis in Lung Cancers Overexpressing Different VEGF Isoforms Assessed by DCE- and SSCE-MRI
- (2011) Ang Yuan et al. PLoS One
- Transdifferentiation of glioblastoma cells into vascular endothelial cells
- (2011) Y. Soda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clinical features and outcomes of posterior reversible encephalopathy syndrome following bevacizumab treatment
- (2011) R. C. S. Seet et al. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
- Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study
- (2011) Vaneja Velenik et al. Radiation Oncology
- Economic burden of toxicities associated with metastatic colorectal cancer treatment regimens containing monoclonal antibodies
- (2011) Chakkarin Burudpakdee et al. JOURNAL OF MEDICAL ECONOMICS
- Tumor Angiogenesis: Pericytes and Maturation Are Not to Be Ignored
- (2011) Elham Fakhrejahani et al. Journal of Oncology
- VEGF-PET Imaging Is a Noninvasive Biomarker Showing Differential Changes in the Tumor during Sunitinib Treatment
- (2010) W. B. Nagengast et al. CANCER RESEARCH
- Experience with sorafenib and adverse event management
- (2010) Joaquim Bellmunt et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Phase II study of Cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF prostate cancer clinical trials consortium
- (2010) Ajjai Alva et al. INVESTIGATIONAL NEW DRUGS
- Phase II Proof-of-Concept Study of Pazopanib Monotherapy in Treatment-Naive Patients With Stage I/II Resectable Non–Small-Cell Lung Cancer
- (2010) Nasser Altorki et al. JOURNAL OF CLINICAL ONCOLOGY
- Gemcitabine Plus Bevacizumab Compared With Gemcitabine Plus Placebo in Patients With Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303)
- (2010) Hedy Lee Kindler et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase III Study of Bevacizumab Plus Docetaxel Compared With Placebo Plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer
- (2010) David W. Miles et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase III Trial of Bevacizumab Plus Interferon Alfa-2a in Patients With Metastatic Renal Cell Carcinoma (AVOREN): Final Analysis of Overall Survival
- (2010) Bernard Escudier et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase III Trial of Bevacizumab Plus Interferon Alfa Versus Interferon Alfa Monotherapy in Patients With Metastatic Renal Cell Carcinoma: Final Results of CALGB 90206
- (2010) Brian I. Rini et al. JOURNAL OF CLINICAL ONCOLOGY
- Disease Course Patterns After Discontinuation of Bevacizumab: Pooled Analysis of Randomized Phase III Trials
- (2010) David Miles et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase III Trial Assessing Bevacizumab in Stages II and III Carcinoma of the Colon: Results of NSABP Protocol C-08
- (2010) Carmen J. Allegra et al. JOURNAL OF CLINICAL ONCOLOGY
- Molecular Imaging of Changes in the Prevalence of Vascular Endothelial Growth Factor Receptor in Sunitinib-Treated Murine Mammary Tumors
- (2010) Z. Levashova et al. JOURNAL OF NUCLEAR MEDICINE
- Angiogenesis and Current Antiangiogenic Strategies for the Treatment of Cancer
- (2010) Rahmi Oklu et al. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
- Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study
- (2010) Federico Cappuzzo et al. LANCET ONCOLOGY
- Finding the tumor copycat: Approximating a human cancer
- (2010) Terry Van Dyke NATURE MEDICINE
- Finding the tumor copycat: Therapy fails, patients don't
- (2010) Lee M Ellis et al. NATURE MEDICINE
- Increased Risk of Serious Hemorrhage with Bevacizumab in Cancer Patients: A Meta-Analysis
- (2010) Sanjaykumar Hapani et al. ONCOLOGY
- Flare-up: An often unreported phenomenon nevertheless familiar to oncologists prescribing tyrosine kinase inhibitors
- (2009) Pascal Wolter et al. ACTA ONCOLOGICA
- Renal Effects of Anti-angiogenesis Therapy: Update for the Internist
- (2009) Faina Gurevich et al. AMERICAN JOURNAL OF MEDICINE
- A “Vascular Normalization Index” as Potential Mechanistic Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent Glioblastoma Patients
- (2009) A. Gregory Sorensen et al. CANCER RESEARCH
- Phase I/II Trial of Bevacizumab and Radiotherapy for Locally Advanced Inoperable Colorectal Cancer: Vasculature-Independent Radiosensitizing Effect of Bevacizumab
- (2009) M. I. Koukourakis et al. CLINICAL CANCER RESEARCH
- Overexpression and activation of EGFR and VEGFR2 in medullary thyroid carcinomas is related to metastasis
- (2009) Cristina Rodríguez-Antona et al. ENDOCRINE-RELATED CANCER
- Current status and future prospects for anti-angiogenic therapies in cancer
- (2009) Carolyn A Staton et al. Expert Opinion on Drug Discovery
- Imaging glioma cell invasionin vivoreveals mechanisms of dissemination and peritumoral angiogenesis
- (2009) Frank Winkler et al. GLIA
- Phase III Trial of Cisplatin Plus Gemcitabine With Either Placebo or Bevacizumab As First-Line Therapy for Nonsquamous Non–Small-Cell Lung Cancer: AVAiL
- (2009) Martin Reck et al. JOURNAL OF CLINICAL ONCOLOGY
- Issues in Using Progression-Free Survival When Evaluating Oncology Products
- (2009) Thomas R. Fleming et al. JOURNAL OF CLINICAL ONCOLOGY
- Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study
- (2009) Christopher G. Willett et al. JOURNAL OF CLINICAL ONCOLOGY
- Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma
- (2009) Henry S. Friedman et al. JOURNAL OF CLINICAL ONCOLOGY
- Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
- (2009) Robert J. Motzer et al. JOURNAL OF CLINICAL ONCOLOGY
- Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis
- (2009) Sanjaykumar Hapani et al. LANCET ONCOLOGY
- Real-time imaging reveals the single steps of brain metastasis formation
- (2009) Yvonne Kienast et al. NATURE MEDICINE
- Chemotherapy, Bevacizumab, and Cetuximab in Metastatic Colorectal Cancer
- (2009) Jolien Tol et al. NEW ENGLAND JOURNAL OF MEDICINE
- Anti-Epidermal Growth Factor Receptor Monotherapy in the Treatment of Metastatic Colorectal Cancer: Where Are We Today?
- (2009) M. Peeters et al. ONCOLOGIST
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistance
- (2009) Yihai Cao et al. SEMINARS IN CANCER BIOLOGY
- Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration
- (2008) John A. Legg et al. ANGIOGENESIS
- Angiogenesis in pre-malignant conditions
- (2008) S R Menakuru et al. BRITISH JOURNAL OF CANCER
- Reversible posterior leukoencephalopathy syndrome associated with bevacizumab/doxorubicin regimen
- (2008) Franck Bürki et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Pharmacology of the Novel Antiangiogenic Peptide ATN-161 (Ac-PHSCN-NH2): Observation of a U-Shaped Dose-Response Curve in Several Preclinical Models of Angiogenesis and Tumor Growth
- (2008) F. Donate et al. CLINICAL CANCER RESEARCH
- Sunitinib Reverses Type-1 Immune Suppression and Decreases T-Regulatory Cells in Renal Cell Carcinoma Patients
- (2008) J. H. Finke et al. CLINICAL CANCER RESEARCH
- New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
- (2008) E.A. Eisenhauer et al. EUROPEAN JOURNAL OF CANCER
- Feasibility of Using Bevacizumab With Radiation Therapy and Temozolomide in Newly Diagnosed High-Grade Glioma
- (2008) Ashwatha Narayana et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Risk of Venous Thromboembolism With the Angiogenesis Inhibitor Bevacizumab in Cancer Patients
- (2008) Shobha Rani Nalluri et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Recurrent Priapism Related to Oxaliplatin Infusion
- (2008) Antoine Adenis et al. JOURNAL OF CLINICAL ONCOLOGY
- Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study
- (2008) Leonard B. Saltz et al. JOURNAL OF CLINICAL ONCOLOGY
- Bevacizumab Beyond First Progression Is Associated With Prolonged Overall Survival in Metastatic Colorectal Cancer: Results From a Large Observational Cohort Study (BRiTE)
- (2008) Axel Grothey et al. JOURNAL OF CLINICAL ONCOLOGY
- Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme
- (2008) David A. Reardon et al. JOURNAL OF CLINICAL ONCOLOGY
- Metronomic Cyclophosphamide and Capecitabine Combined With Bevacizumab in Advanced Breast Cancer
- (2008) Silvia Dellapasqua et al. JOURNAL OF CLINICAL ONCOLOGY
- Design and End Points of Clinical Trials for Patients With Progressive Prostate Cancer and Castrate Levels of Testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group
- (2008) Howard I. Scher et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma
- (2008) Teri N. Kreisl et al. JOURNAL OF CLINICAL ONCOLOGY
- Overexpression of VEGF is associated with positive p53 immunostaining in hepatocellular carcinoma (HCC) and adverse outcome of HCC patients
- (2008) Po-Lin Tseng et al. JOURNAL OF SURGICAL ONCOLOGY
- Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation
- (2008) W Zhao et al. LEUKEMIA
- Progression-free survival: An important end point in evaluating therapy for recurrent high-grade gliomas
- (2008) Kathleen R. Lamborn et al. NEURO-ONCOLOGY
- Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence
- (2008) A. D. Norden et al. NEUROLOGY
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tumor Angiogenesis
- (2008) Robert S. Kerbel NEW ENGLAND JOURNAL OF MEDICINE
- Endpoints for Assessing Drug Activity in Clinical Trials
- (2008) R. Pazdur ONCOLOGIST
- Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses
- (2008) P. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations?
- (2008) Cristiana Sessa et al. Nature clinical practice. Oncology
- Development trends for new cancer therapeutics and vaccines
- (2007) J REICHERT DRUG DISCOVERY TODAY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now