Article
Entomology
Jiewei Wang, Qiang Liu, Yuan Gong, Li Hua Jin
Summary: The adult Drosophila intestinal epithelium is tightly regulated by the G protein-coupled receptor Anchor to maintain homeostasis. Inactivation of anchor leads to aberrant activation of the JNK and Notch pathways, affecting stem cell differentiation and proliferation, ultimately causing sensitivity to environmental challenges.
JOURNAL OF INSECT PHYSIOLOGY
(2021)
Article
Cell Biology
Xi Liu, Peter Nagy, Alessandro Bonfini, Philip Houtz, Xiao-Li Bing, Xiaowei Yang, Nicolas Buchon
Summary: Gut microbes play an important role in the differentiation of gut stem cells, influencing epithelial composition and gut physiology. The balance between microbial pattern recognition pathways and damage response pathways is crucial for stem cell differentiation.
Article
Biology
Jinnan Xiang, Jigang Guo, Shaoyang Zhang, Hongguang Wu, Ye-Guang Chen, Junping Wang, Baojie Li, Huijuan Liu
Summary: This study found that the Twist2 stromal lineage cells play a crucial role in the growth and maintenance of intestinal stem cells (ISCs) and their ability to regenerate villi. Additionally, Acta2(+) cells also contribute to ISC regeneration. These findings suggest that different cellular niches are required for ISC-mediated villus homeostasis and regeneration.
Review
Gastroenterology & Hepatology
Anne R. Meyer, Monica E. Brown, Patrick S. McGrath, Peter J. Dempsey
Summary: The ability of intestinal epithelial cells to revert to a stem cell state is an important physiological response to regenerate the intestinal epithelium after mucosal injury. Activation of signaling networks involved in maintaining the stem cell niche promotes cellular plasticity and regeneration. Further research is needed to determine the contribution of each cell type and signaling pathway in the multicellular cooperation to restore the intestinal epithelium.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Food Science & Technology
Ning Ma, Xiyue Chen, Chunchen Liu, Yiwei Sun, Lee J. Johnston, Xi Ma
Summary: This article reviews the critical role of intestinal stem cells (ISCs) in governing the proliferation and differentiation of the intestinal epithelium, as well as the regulation of ISCs by dietary factors. Through pathways such as mTORC1, PPAR/CPT1 alpha, PPAR gamma/beta-catenin, and Wnt/GSK-3 beta, factors such as caloric restriction, fasting, fat, glucose, and trace elements in the diet affect the function and self-renewal of ISCs, and may serve as potential targets for cancer prevention. However, a lack of precise definitions of nutrition intervention hinders our understanding of the biological response of ISCs to nutrients.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cell Biology
Min Deng, Christian F. Guerrero-Juarez, Xiaole Sheng, Jiuzhi Xu, Xi Wu, Kai Yao, Mengzhen Li, Xu Yang, Guilin Li, Jintao Xiao, Xiaowei Liu, Kaichun Wu, Fazheng Ren, Qing Nie, Maksim Plikus, Zhengquan Yu, Cong Lv
Summary: This study reveals that mesenchymal cells (MCs) surrounding the intestine can sense diet changes and modulate the function of intestinal stem cells (ISCs) through the secretion of IGF1. MCs play a critical role in maintaining the proliferation of ISC and progenitor cells, and these findings may provide a novel therapeutic target for gut diseases.
Article
Medicine, Research & Experimental
Danni Yu, Quanhui Dai, Zixiang Wang, Steven X. Hou, Ling V. Sun
Summary: This study aimed to explore the role of ARF1 in intestinal epithelial cells (IECs) and reveal the possible mechanism. The results showed that ARF1 is essential for ISC proliferation and differentiation. Loss of ARF1 increased susceptibility to DSS-induced colitis and gut microbial dysbiosis. Additionally, RNA-seq analysis revealed alterations in multiple metabolic pathways.
Editorial Material
Cell Biology
Louis Gervais, Allison J. Bardin
Summary: The vascular system is a crucial regulator of adult stem cells, as demonstrated by two studies showing that the vascular-like Drosophila trachea undergoes reshaping after intestinal damage or tumor formation, which is necessary for compensatory intestinal stem cell proliferation and tumor growth.
NATURE CELL BIOLOGY
(2021)
Article
Immunology
Jing Wang, Dongdong Zhao, Zehui Lei, Pupu Ge, Zhe Lu, Qiyao Chai, Yong Zhang, Lihua Qiang, Yang Yu, Xinwen Zhang, Bingxi Li, Shu Zhu, Lingqiang Zhang, Cui Hua Liu
Summary: Dysregulation of gut homeostasis is associated with irritable bowel syndrome (IBS), a chronic functional gastrointestinal disorder. In this study, researchers found that the expression of the E3 ubiquitin ligase tripartite motif-containing 27 (TRIM27) is weakly expressed in IBS but highly expressed in inflammatory bowel disease (IBD). Knockout of Trim27 in mice causes IBS-like symptoms, and mechanistically, TRIM27 stabilizes beta-catenin and activates Wnt/beta-catenin signaling to promote intestinal stem cell (ISC) self-renewal. Targeting the TRIM27/Wnt/beta-catenin axis could be a potential treatment strategy for IBS, and TRIM27 might serve as a potential biomarker for differentiating IBS from IBD.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Haoming Luo, Mingxing Li, Fang Wang, Yifei Yang, Qin Wang, Yueshui Zhao, Fukuan Du, Yu Chen, Jing Shen, Qianyun Zhao, Jiuping Zeng, Shengpeng Wang, Meijuan Chen, Xiaobing Li, Wanping Li, Yuhong Sun, Li Gu, Qinglian Wen, Zhangang Xiao, Xu Wu
Summary: This article reviews the interplay between intestinal stem cells and gut microbiota in their local environment, and discusses the progress and future directions of intestinal organoid culture.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Immunology
Pailin Chiaranunt, Siu Ling Tai, Louis Ngai, Arthur Mortha
Summary: Intestinal macrophages, the largest macrophage population in the body, not only play a role in immunity but also have crucial non-immune functions. Recent research suggests that the functional diversity of macrophages in the gut goes beyond classical immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ashutosh Pandey, Antonio Galeone, Seung Yeop Han, Benjamin A. Story, Gaia Consonni, William F. Mueller, Lars M. Steinmetz, Thomas Vaccari, Hamed Jafar-Nejad
Summary: Intestinal barrier dysfunction can cause inflammation and metabolic changes. However, the impact of gut bacteria versus non-bacterial insults on animal health in the context of barrier dysfunction is not well understood. This study establishes that loss of Drosophila N-glycanase 1 (Pngl) in a specific intestinal cell type leads to gut barrier defects, causing starvation and JNK overactivation. Loss of Pngl also results in immune and metabolic abnormalities, contributing to lethality.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Xiaoyu Tracy Cai, Hongjie Li, Martin Borch Jensen, Elie Maksoud, Jovencio Borneo, Yuxin Liang, Stephen R. Quake, Liqun Luo, Pejmun Haghighi, Heinrich Jasper
Summary: Glial metabolic reprogramming by gut-derived cytokines in Drosophila results in lasting changes in the sensory system of an ageing organism. This metabolic reprogramming is transient in young flies but becomes constitutive in old flies, contributing to an age-related decline in sensory discrimination.
Review
Endocrinology & Metabolism
Ilias Moraitis, Jordi Guiu, Josep Rubert
Summary: Cancer is the second leading cause of death worldwide, causing nearly 10 million deaths in 2020. Radiotherapy is commonly used for its anticancer effects, but it also leads to healthy tissue toxicity. In cases of abdominal and pelvic malignancies, the healthy bowel is unavoidably exposed to radiation, resulting in radiation-induced enteritis and significant impact on the gut microbiome. This review provides a critical analysis of the factors influencing the gut microenvironment in homeostasis, disease, and injury, focusing on the role of gut microbial metabolites and microorganisms in epithelial regeneration after radiation injury.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Cell Biology
Brisa Palikuqi, Jeremie Rispal, Ophir Klein
Summary: The intestinal epithelium undergoes continuous cellular turnover, and intestinal stem cells (ISCs) can both self-renew and differentiate. Under stress conditions, intestinal epithelial cells are quite plastic, allowing for dedifferentiation and reversal of cell fate. The ISC niche, made up of various cell types, plays a central role in intestinal function.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joung-Sun Park, Su-Ryun Kim, So-Young Park, Dong-Jin Yang, Shin-Hae Lee, Ybon-Jeong Choi, Moon-Kyoung Bae, Masamitsu Yamaguchi, Young-Shin Kim, Mi-Ae Yoo
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2008)
Article
Biochemistry & Molecular Biology
Joung-Sun Park, Young-Shin Kim, Joong-Gook Kim, Shin-Hae Lee, So-Young Park, Masamitsu Yamaguchi, Mi-Ae Yoo
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2010)
Article
Geriatrics & Gerontology
Joung-Sun Park, Shin-Hae Lee, Hyun-Jin Na, Jung-Hoon Pyo, Young-Shin Kim, Mi-Ae Yoo
EXPERIMENTAL GERONTOLOGY
(2012)
Article
Cell Biology
Shin-Hae Lee, Su-Kyung Lee, Donggi Paik, Kyung-Jin Min
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2012)