Article
Biology
Melina Hussmann, Dorte Schulte, Sarah Weischer, Claudia Carlantoni, Hiroyuki Nakajima, Naoki Mochizuki, Didier Y. R. Stainier, Thomas Zobel, Manuel Koch, Stefan Schulte-Merker, Victoria L. Bautch
Summary: This study reveals the critical roles of Svep1 and Tie1 in the development of specific subpopulations of the zebrafish facial lymphatic network. It also shows that this aspect of the network is formed independently of Vegfc signaling. The findings demonstrate the importance of Tie1 signaling in lymphangiogenesis and blood vessel development in zebrafish.
Article
Oncology
Maureen Van de Velde, Marie Ebroin, Tania Durre, Marc Joiret, Lionel Gillot, Silvia Blacher, Liesbet Geris, Frederic Kridelka, Agnes Noel
Summary: This study revealed a new mechanism by which tumor exposed-LEC promote tumor cell proliferation, showcasing their role in enhancing cancer cell invasion and proliferation in vivo. The analysis of teLEC secretome identified IL6 as a key molecule modulated in teLEC, with neutralization of IL6 abolishing the mitogenic effects mediated by teLEC in vivo. The findings suggest a novel function for teLEC beyond their traditional role in lymphatic vessel formation, emphasizing their potential as key stromal determinants in future studies.
Article
Engineering, Biomedical
Kevin T. Campbell, Matthew B. Curtis, Joshua M. Massey, Kajetan Wysoczynski, Dustin J. Hadley, Steve C. George, Eduardo A. Silva
Summary: Lymphatic dysfunction is associated with the progression of several vascular disorders, and there are limited strategies currently available to promote new lymphatic vasculature. This study isolated lymphatic endothelial progenitor cells from human umbilical cord blood and found that they have the potential to promote lymphatic sprouts, highlighting the therapeutic potential of these cells. Delivery of lymphatic EPCs using alginate hydrogels also showed promise for possible therapeutic applications.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Carina Hromada, Jaana Hartmann, Johannes Oesterreicher, Anton Stoiber, Anna Daerr, Barbara Schaedl, Eleni Priglinger, Andreas H. Teuschl-Woller, Wolfgang Holnthoner, Johannes Heinzel, David Hercher
Summary: This study reveals increased lymphangiogenesis after peripheral nerve injury and repair. The findings suggest that Schwann cells may have an inhibitory effect on lymphatic vessel formation.
Article
Biology
Di Peng, Koji Ando, Melina Hussmann, Marleen Gloger, Renae Skoczylas, Naoki Mochizuki, Christer Betsholtz, Shigetomo Fukuhara, Stefan Schulte-Merker, Nathan D. Lawson, Katarzyna Koltowska
Summary: In zebrafish, arterial mural cells have been identified as a crucial source of signals that guide the migration and survival of lymphatic endothelial cells (LECs), promoting the establishment of the lymphatic vascular network. The cooperative function of chemokine and growth factor signaling, particularly through the VEGFC-VEGFR3 pathway, plays a key role in LEC migration.
Article
Hematology
Bhupesh Singla, Ravi Varma Aithbathula, Naveed Pervaiz, Ishita Kathuria, Mallory Swanson, Frederick Adams Ekuban, WonMo Ahn, Frank Park, Maxwell Gyamfi, Mary Cherian-Shaw, Udai P. Singh, Santosh Kumar
Summary: CD47 plays a crucial role in lymphangiogenesis and atherosclerosis by interacting with TSP1. Activation of CD47 by TSP1 inhibits lymphangiogenesis, and loss of CD47 in lymphatic endothelial cells attenuates the formation of atherosclerotic lesions. Therefore, CD47 in lymphatic endothelial cells may serve as a potential therapeutic target for atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marta Turati, Gianluca Mattei, Alessia Boaretto, Alberto Magi, Maura Calvani, Roberto Ronca
Summary: The lymphatic vascular system plays a crucial role in cancer progression by activating lymphatic endothelial cells and facilitating the formation of new lymphatic vessels. This study revealed that cancer-derived and microenvironmental mediators activate specific molecular pathways in lymphatic endothelial cells, leading to endothelial activation, morphogenesis, and cytokine-mediated signaling. The findings provide new insights into the lymphangiogenesis process and its relevance in different types of tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Peripheral Vascular Disease
Daniyal J. Jafree, David A. Long, Peter J. Scambler, Christiana Ruhrberg
Summary: Lymphatic vessels play critical roles in both health and disease, and research in this field is rapidly evolving. Recent studies have revealed new cellular mechanisms and diverse cell lineages involved in the formation of organ lymphatic vasculature.
Article
Biochemistry & Molecular Biology
Hayan Kwon, Ja-Young Kwon, Jeeun Song, Yong-Sun Maeng
Summary: Research has shown that offspring exposed to preeclampsia (PE) in utero have decreased lymphangiogenic activities in lymphatic endothelial progenitor cells (LEPCs) both in vitro and in vivo, along with decreased expression of pro-lymphangiogenic genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jing-Yun Wen, Xing Li, Jian-Ning Chen, Jie Chen, Jing-Yue Zhang, Yu Du, Wei-Hang Zhu, Yong-Jian Chen, Ri-Hong Yang, Chun-Kui Shao
Summary: CD45(-) EPCs are found to be accumulated in GC tissues and metastatic LNs and promote LN metastasis through the S100A8/9-induced hybrid E/M state of LECs, which is the specific mechanism of LN metastasis in the early stages of GC. CD45(-) EPCs can predict the overall and disease-free survival of stage I-III GC patients after radical resection.
Article
Multidisciplinary Sciences
Shira Landau, Abigail Newman, Shlomit Edri, Inbal Michael, Shahar Ben-Shaul, Yulia Shandalov, Tom Ben-Arye, Pritinder Kaur, Ming H. Zheng, Shulamit Levenberg
Summary: Lymphatic system plays a critical role in various biological processes, yet lymphangiogenesis is less studied compared to angiogenesis. By culturing human lymphatic endothelial cells on thick collagen sheets with supporting cells and blood endothelial cells, a functional lymphatic vessel network was successfully developed in a short period of time. The model provides a potential platform for investigating lymphangiogenesis and lymphatic disease mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Peripheral Vascular Disease
Racheal Grace Akwii, Md Sanaullah Sajib, Fatema Tuz Zahra, Paul Tullar, Masoud Zabet-Moghaddam, Yi Zheng, J. Silvio Gutkind, Colleen L. Doci, Constantinos M. Mikelis
Summary: Lymphangiogenesis is a crucial process regulated by Angiopoietin-2 (Ang2) and RhoA. The migration of lymphatic endothelial cells induced by Ang2 relies on RhoA activation mediated by beta 1 integrin, and formins, particularly FHOD1, are identified as key downstream players of RhoA. RhoA deficiency in lymphatic endothelial cells impedes Ang2-induced lymphangiogenesis.
Article
Immunology
Maria M. Steele, Abhinav Jaiswal, Ines Delclaux, Ian D. Dryg, Dhaarini Murugan, Julia Femel, Sunny Son, Haley du Bois, Cameron Hill, Sancy A. Leachman, Young H. Chang, Lisa M. Coussens, Niroshana Anandasabapathy, Amanda W. Lund
Summary: The authors demonstrate that CD8(+) T cells exit tumors through lymphatic vessels in a CXCL12/CXCR4-dependent manner. Encounter with high-affinity antigen inhibits CXCR4 and increases retention, while no encounter or weak affinity directs T cell exit to limit local tumor control. Tumor-associated lymphatic vessels control T cell exit via CXCL12, and intratumoral antigen encounter tunes CXCR4 expression. Inhibition of CXCR4 or loss of lymphatic-specific CXCL12 enhances T cell retention and tumor control, suggesting that strategies to limit T cell egress could improve immunotherapy response.
Review
Physiology
Tomohiro Shiiya, Masanori Hirashima
Summary: During development, lymphatic endothelial cell (LEC) progenitors differentiate from venous endothelial cells only in limited regions of the body. LEC migration and subsequent tube formation are essential processes for the development of tubular lymphatic vascular network throughout the body. This review discusses the chemotactic factors, LEC-extracellular matrix interactions, and planar cell polarity regulating LEC migration and formation of tubular lymphatic vessels, providing insights into the molecular mechanisms underlying physiological lymphatic vascular development and lymphangiogenesis associated with pathological conditions.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Developmental Biology
Mathias Francois, Anna Oszmiana, Natasha L. Harvey
Summary: The lymphatic vasculature is crucial for tissue fluid homeostasis, immune cell trafficking, and lipid absorption from the digestive tract. Recent advancements in understanding the genetic and cellular events involved in lymphatic vasculature development have identified new sources of lymphatic endothelial progenitor cells, revealed endothelial cell specialization and heterogeneity, and discovered novel genes and signaling pathways essential for lymphangiogenesis during development.
Article
Gastroenterology & Hepatology
Cheryl de Valliere, Solange Vidal, Ieuan Clay, Giorgia Jurisic, Irina Tcymbarevich, Silvia Lang, Marie-Gabrielle Ludwig, Michal Okoniewski, Jyrki J. Eloranta, Gerd A. Kullak-Ublick, Carsten A. Wagner, Gerhard Rogler, Klaus Seuwen
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2015)
Article
Gastroenterology & Hepatology
Patricia Marti, Claudia Stein, Tanja Blumer, Yann Abraham, Michael T. Dill, Monika Pikiolek, Vanessa Orsini, Giorgia Jurisic, Philippe Megel, Zuzanna Makowska, Claudia Agarinis, Luigi Tornillo, Tewis Bouwmeester, Heinz Ruffner, Andreas Bauer, Christian N. Parker, Tobias Schmelzle, Luigi M. Terracciano, Markus H. Heim, Jan S. Tchorz
Article
Developmental Biology
Alexandra M. Ochsenbein, Sinem Karaman, Steven T. Proulx, Michaela Berchtold, Giorgia Jurisic, Esther T. Stoeckli, Michael Detmar
Article
Neurosciences
P. S. Hosford, V. Mosienko, K. Kishi, G. Jurisic, K. Seuwen, B. Kinzel, M. G. Ludwig, J. A. Wells, I. N. Christie, L. Koolen, A. P. Abdala, B. H. Liu, A. V. Gourine, A. G. Teschemacher, S. Kasparov
Review
Cell Biology
Giorgia Jurisic, Michael Detmar
CELL AND TISSUE RESEARCH
(2009)
Article
Cardiac & Cardiovascular Systems
Giorgia Jurisic, Helene Maby-El Hajjami, Sinem Karaman, Alexandra M. Ochsenbein, Annamari Alitalo, Shoib S. Siddiqui, Carlos Ochoa Pereira, Tatiana V. Petrova, Michael Detmar
CIRCULATION RESEARCH
(2012)
Article
Oncology
Giorgia Jurisic, Maria Iolyeva, Steven T. Proulx, Cornelia Halin, Michael Detmar
EXPERIMENTAL CELL RESEARCH
(2010)
Article
Genetics & Heredity
G. Jurisic, J. P. Sundberg, A. Bleich, E. H. Leiter, K. W. Broman, G. Buechler, L. Alley, D. Vestweber, M. Detmar
GENES AND IMMUNITY
(2010)
Article
Gastroenterology & Hepatology
Giorgia Jurisic, John P. Sundberg, Michael Detmar
INFLAMMATORY BOWEL DISEASES
(2013)
Article
Biochemistry & Molecular Biology
Nadejda Valtcheva, Adriana Primorac, Giorgia Jurisic, Maija Hollmen, Michael Detmar
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Deena M. Leslie Pedrioli, Terhi Karpanen, Vasilios Dabouras, Giorgia Jurisic, Glenn van de Hoek, Jay W. Shin, Daniela Marino, Roland E. Kaelin, Sebastian Leidel, Paolo Cinelli, Stefan Schulte-Merker, Andre W. Braendli, Michael Detmar
MOLECULAR AND CELLULAR BIOLOGY
(2010)