Article
Cell Biology
Malgorzata Gajdzis, Stamatios Theocharis, Jerzy Klijanienko, Nathalie Cassoux, Sophie Gardrat, Piotr Donizy, Radoslaw Kaczmarek, Pawel Gajdzis
Summary: This study found that high expression of PARP-1 in uveal melanoma is associated with unfavorable clinicopathological parameters and prognosis.
Article
Pharmacology & Pharmacy
Jennifer Moran, Eimear Mylod, Laura E. Kane, Caroline Marion, Emily Keenan, Marianna Mekhaeil, Joanne Lysaght, Kumlesh K. Dev, Jacintha O'Sullivan, Melissa J. Conroy
Summary: Glioblastoma multiforme (GBM), the most common primary brain malignancy in adults, has a low survival rate of about 14.6 months. The current standard-of-care for GBM includes surgery and chemoradiotherapy, but the response to treatment is limited due to factors such as tumor heterogeneity, treatment resistance, the blood-brain barrier, and immunosuppression. Olaparib, an FDA-approved drug for BRCA-mutated ovarian and breast cancer, has been found to enhance radio- and chemo-sensitivity in GBM and its ability to enhance natural killer (NK) cell-mediated responses is reported in other types of cancer. This study investigated the combination of Olaparib with NK cell therapies in GBM and found that Olaparib does not affect the susceptibility of GBM cells to NK cells or the function of NK cells. These findings provide new insights into the potential of combining Olaparib with NK cell therapies for GBM.
Review
Immunology
Abolfazl Maghrouni, Maryam Givari, Mohammad Jalili-Nik, Hamid Mollazadeh, Bahram Bibak, Mohammad Montazami Sadeghi, Amir R. Afshari, Thomas P. Johnston, Amirhossein Sahebkar
Summary: GBM, an immunosuppressive brain tumor, remains difficult to manage despite current treatments. Immunotherapy, particularly checkpoint inhibitors, has potential for GBM treatment but faces challenges due to the tumor's immunosuppressive microenvironment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Suprava Das, Banendu Sunder Dash, Thejas P. Premji, Jyh-Ping Chen
Summary: This review discusses the mechanisms, benefits, and limitations of various immunotherapeutic approaches for glioblastoma (GBM) treatment, including immune checkpoint inhibitors, chimeric antigen receptors T cells, natural killer cells, vaccines, and combination therapy. It emphasizes the importance of immunotherapy in overcoming the current treatment limitations and improving survival rates in GBM patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fabiana Moresi, Diana Valeria Rossetti, Federica Vincenzoni, Giorgia Antonia Simboli, Giuseppe La Rocca, Alessandro Olivi, Andrea Urbani, Giovanni Sabatino, Claudia Desiderio
Summary: This study applied a bioinformatic approach to investigate specific sub-proteomes in Cavitating Ultrasound Aspirator (CUSA) fluid pools of glioblastomas, aiming to understand the aggressive behavior of this brain cancer. The results showed the over-representation of certain pathways in different protein classifications and revealed variations in protein distribution between newly diagnosed and recurrent tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
M. Anu, Joyal Xavier, A. S. Fathima, Priya Bisht, Krishna Murti, V. Ravichandiran, Nitesh Kumar
Summary: Epigenetic modifications play a crucial role in glioblastoma genes, affecting the development of neural stem cells. Inhibiting PARP can induce cell damage and enhance the effects of chemotherapy and radiotherapy. PARPi is an innovative drug explored for the treatment of glioma, but not all patients respond to it.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jiaqi Liu, Yuting Sun, Xianhuang Zeng, Yang Liu, Chaozhi Liu, Ying Zhou, Yueguang Liu, Guihong Sun, Mingxiong Guo
Summary: This study developed artificial vesicles loaded with ANG-TRP-PK1 peptides for targeted therapy of brain tumors. The peptide-loaded vesicles showed better therapeutic effects and reduced side effects compared to traditional drugs in mouse models.
ADVANCED MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Mary-Ann Xavier, Fernando Rezende, Ricardo Titze-de-Almeida, Bart Cornelissen
Summary: The treatment of GBM patients can be enhanced by combining PARP inhibitors with DNA-damaging therapies, and the responsiveness of patients to treatment can be accurately predicted by timely biomarkers of BRCAness.
Article
Chemistry, Multidisciplinary
Jiantang Liang, Lei Li, Hailong Tian, Zhihan Wang, Guowen Liu, Xirui Duan, Meiwen Guo, Jiaqi Liu, Wei Zhang, Edouard C. Nice, Canhua Huang, Weifeng He, Haiyuan Zhang, Qifu Li
Summary: Developing therapies that can effectively target glioblastoma by crossing the blood-brain barrier (BBB) and induce ferroptosis is crucial for improving treatment outcomes. In this study, a versatile biomimetic nanoplatform, L-D-I/NPs, was designed for selective targeting of glioblastoma by binding to low-density lipoprotein receptor-related protein-1 (LRP1) and crossing the BBB, thus inducing ferroptosis in glioblastoma cells. L-D-I/NPs have demonstrated the ability to effectively suppress tumor progression and prolong survival in a mouse glioblastoma model, offering a promising approach for ferroptosis-based therapies.
Article
Chemistry, Multidisciplinary
Reena Jatyan, Deepak Kumar Sahel, Prabhjeet Singh, Rajeev Sakhuja, Anupama Mittal, Deepak Chitkara
Summary: In this study, the conjugation of fatty acids with temozolomide improved its anticancer potential against glioblastoma multiforme. The synthesized conjugates showed a stronger inhibitory effect on tumor cells in vitro and improved survival rate in an animal model.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Giuseppe La Rocca, Giorgia Antonia Simboli, Federica Vincenzoni, Diana Valeria Rossetti, Andrea Urbani, Tamara Ius, Giuseppe Maria Della Pepa, Alessandro Olivi, Giovanni Sabatino, Claudia Desiderio
Summary: Through comparing the protein profiles of newly diagnosed and recurrent glioblastoma, distinct and common protein elements in different tumor zones and states could be identified, shedding light on the molecular mechanisms of this aggressive brain tumor.
Article
Multidisciplinary Sciences
Yuanning Zheng, Francisco Carrillo-Perez, Marija Pizurica, Dieter Henrik Heiland, Olivier Gevaert
Summary: In this study, two deep learning models were used to predict the transcriptional subtypes and prognosis of glioblastoma (GBM) cells from histology images. The results showed consistent associations between spatial cellular organization and patient prognosis. The study also confirmed that transcriptional heterogeneity and cell-state plasticity are key factors in the development of therapeutic resistance in GBM.
NATURE COMMUNICATIONS
(2023)
Review
Medicine, Research & Experimental
Sepideh Mirzaei, Mahmood Khaksary Mahabady, Amirhossein Zabolian, Alireza Abbaspour, Peyman Fallahzadeh, Maedeh Noori, Farid Hashemi, Kiavash Hushmandi, Salman Daneshi, Alan Prem Kumar, Amir Reza Aref, Saeed Samarghandian, Pooyan Makvandi, Haroon Khan, Michael R. Hamblin, Milad Ashrafizadeh, Ali Zarrabi
Summary: GBM is a serious brain tumor with no cure, requiring new genetic approaches for treatment. The use of siRNA can target and silence genes responsible for disease progression in GBM cells.
Article
Microbiology
Zihao Yuan, Yuntao Yang, Ningyan Zhang, Claudio Soto, Xiaoqian Jiang, Zhiqiang An, Wenjin Jim Zheng
Summary: The study reveals significant differential expression of many HERV LTR elements in GBM and normal brain tissues. The expression levels of these elements could potentially be developed as biomarkers for GBM treatments.
Article
Oncology
Wei-Hao Liao, Ming-Yen Hsiao, Yi Kung, Abel Po-Hao Huang, Wen-Shiang Chen
Summary: GBM is a devastating brain tumor with challenges in drug delivery due to the blood-brain barrier. Research shows that using shockwave (SW), a form of transcranial focused ultrasound, can efficiently open the blood-brain barrier and improve drug delivery, leading to enhanced therapeutic efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michele Salemi, Federico Ridolfo, Maria Grazia Salluzzo, Francesca A. A. Schillaci, Salvatore Caniglia, Bartolo Lanuzza, Mariagiovanna Cantone, Raffaele Ferri
Summary: Bradykinesia, tremor, rigidity and postural instability are the hallmark of Parkinson's disease (PD). In this study, increased Humanin mRNA levels were found in peripheral blood mononuclear cells (PBMCs) of PD patients, which may serve as a marker for a better diagnosis of PD.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Medicine, General & Internal
Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero, Rossella Cannarella, Antonio Aversa
Summary: This study prospectively investigates the effects of liraglutide, a GLP1 analog, on reproductive and sexual function in men with metabolic hypogonadism. The results show that liraglutide significantly improves sperm parameters and erectile function, as well as increasing testosterone and sex hormone-binding globulin levels. This suggests that liraglutide is a useful pharmacological treatment for male patients with metabolic hypogonadism.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Andrology
Andrea Crafa, Rosita Angela Condorelli, Sandro La Vignera, Aldo Eugenio Calogero, Rossella Cannarella
Summary: This article presents a clinical case of a globozoospermic patient with a new mutation of the DPY19L2 gene and provides recommendations based on a systematic literature review on gene mutations, assisted reproductive techniques, and the risk of genetic abnormalities transmission. The study highlights the importance of genetic evaluation and specific assisted reproductive techniques in managing globozoospermia patients.
WORLD JOURNAL OF MENS HEALTH
(2023)
Review
Andrology
Aldo E. Calogero, Rossella Cannarella, Ashok Agarwal, Taha Abo-Almagd Abdel-Meguid Hamoda, Amarnath Rambhatla, Ramadan Saleh, Florence Boitrelle, Imad Ziouziou, Tuncay Toprak, Murat Gul, Tomer Avidor-Reiss, Parviz Kavoussi, Eric Chung, Ponco Birowo, Ramy Abou Ghayda, Edmund Ko, Giovanni Colpi, Fotios Dimitriadis, Giorgio Ivan Russo, Marlon Martinez, Gokhan Calik, Hussein Kandil, Gianmaria Salvio, Taymour Mostafa, Haocheng Lin, Hyun Jun Park, Nazim Gherabi, Nguyen Ho Vinh Phuoc, Nguyen Quang, Ricky Adriansjah, Sandro La Vignera, Sava Micic, Damayanthi Durairajanayagam, Ege Can Serefoglu, Vilvapathy Senguttuvan Karthikeyan, Priyank Kothari, Widi Atmoko, Rupin Shah
Summary: Infertility affects nearly 186 million people worldwide, with male infertility accounting for about half of the cases. There has been a decline in sperm concentration and total count over the past four decades, emphasizing the need for further research in Andrology.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Rossella Cannarella, Francesca Mancuso, Nunziata Barone, Iva Arato, Cinzia Lilli, Catia Bellucci, Marco Musmeci, Giovanni Luca, Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero
Summary: This study evaluated the expression of the follicle-stimulating hormone receptor (FSHR) in human spermatozoa and its effects on sperm function. The results showed that FSHR is expressed in the post-acrosomal segment, neck, midpiece, and tail of human spermatozoa, with no difference in localization between patients and controls. Incubation with FSH increased FSHR expression in patients. Furthermore, FSH incubation had a negative effect on sperm motility and mitochondrial function in both patients and controls, but more severely in controls. FSH also activated the AKT(473) signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rossella Cannarella, Carmelo Gusmano, Rosita A. Condorelli, Andrea Bernini, Jurgen Kaftalli, Paolo Enrico Maltese, Stefano Paolacci, Astrit Dautaj, Giuseppe Marceddu, Matteo Bertelli, Sandro La Vignera, Aldo E. Calogero
Summary: This study investigated five unrelated patients with cHH/KS and identified a new pathogenic variant in the CHD7 gene and three new variants of unknown significance in the IL17RD, FGF17, and DUSP6 genes. Further functional studies are needed to confirm their association with cHH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Rossella Cannarella, Andrea Crafa, Federica Barbagallo, Scott D. D. Lundy, Sandro La Vignera, Rosita A. A. Condorelli, Aldo E. E. Calogero
Summary: This systematic review and meta-analysis examine the differences in H19 gene methylation between patients with abnormal versus normal sperm parameters. The study also explores the impact of age and sperm concentration on H19 methylation using meta-regression analysis. The results indicate that H19 methylation levels are lower in infertile patients, particularly those with oligozoospermia or recurrent pregnancy loss, and are independent of age and sperm concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Andrea Crafa, Aldo Eugenio Calogero, Rossella Cannarella, Rosita Angela Condorelli, Antonio Aversa, Sandro La Vignera
Summary: Male infertility and prostate cancer are the most researched andrological diseases, followed by benign prostatic hyperplasia and erectile dysfunction, which are expected to increase in prevalence due to population aging. However, research on inflammation of the accessory sexual glands is relatively scarce.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Rossella Cannarella, Cristina M. B. Petralia, Rosita A. Condorelli, Antonio Aversa, Aldo E. Calogero, Sandro La Vignera
Summary: This article provides an overview of the molecular mechanisms and usage of follicle-stimulating hormone (FSH) in the treatment of male infertility. It also evaluates the predictor factors of FSH administration response and the indications of the latest guidelines on the use of FSH in male infertility treatment.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Biochemistry & Molecular Biology
Alyssa J. J. Paganoni, Rossella Cannarella, Roberto Oleari, Federica Amoruso, Renata Antal, Marco Ruzza, Chiara Olivieri, Rosita A. Condorelli, Sandro La Vignera, Fationa Tolaj, Anna Cariboni, Aldo E. Calogero, Paolo Magni
Summary: Gonadotropin-releasing hormone (GnRH) neurons play a crucial role in regulating reproduction. AMH, GH, and IGF1 were found to enhance the migration and function of GnRH neurons in vitro. However, their involvement in the development and function of GnRH neurons in vivo remains unknown. This study evaluated the expression of AMHR2, GHR, and IGF1R during different developmental stages in mice, revealing differential protein expression patterns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Andrea Crafa, Claudia Leanza, Rosita A. Condorelli, Sandro La Vignera, Aldo E. Calogero, Rossella Cannarella
Summary: This study suggests that the methylation degree of the LINE1 gene in sperm does not play a determining role in male infertility and/or abnormal sperm parameters. It also indicates that LINE1 should not be included in the genetic panel for identifying the most representative and cost-effective genes in couples undergoing ART cycles.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Review
Nutrition & Dietetics
Vincenzo Garofalo, Rosita A. Condorelli, Rossella Cannarella, Antonio Aversa, Aldo E. Calogero, Sandro La Vignera
Summary: This systematic review and meta-analysis examines the relationship between iron deficiency and thyroid function. The analysis reveals that patients with iron deficiency have lower thyroid hormone levels, especially in pregnant women. It also shows that iron deficiency increases the prevalence of thyroid autoantibodies.
Review
Andrology
Rossella Cannarella, Claudia Leanza, Andrea Crafa, Federica Barbagallo, Sandro La Vignera, Rosita Angela Condorelli, Aldo Eugenio Calogero
Summary: This study examined the impact of MEST gene methylation pattern on sperm parameters in infertile patients and found that MEST gene methylation was higher in infertile patients compared to normal men.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Andrology
Rossella Cannarella, Matteo Bertelli, Rosita A. Condorelli, Marija Vilaj, Sandro La Vignera, Davor Jezek, Aldo E. Calogero
Summary: This study revealed that different mutations of the same gene can result in various testicular histological pictures. It suggests that it is the type of gene mutation/variation rather than the gene itself that determines the testicular histology. However, designing a genetic panel with prognostic value for testicular sperm extraction in patients with NOA remains challenging.
WORLD JOURNAL OF MENS HEALTH
(2023)