Protein folding, misfolding and quality control: the role of molecular chaperones

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone

(2013) Sae-Hun Park et al.   CELL

Chaperone-Interacting TPR Proteins in Caenorhabditis elegans

(2013) Veronika Haslbeck et al.   JOURNAL OF MOLECULAR BIOLOGY

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

(2013) Stéphanie Escusa-Toret et al.   NATURE CELL BIOLOGY

A network of genes connects polyglutamine toxicity to ploidy control in yeast

(2013) Christoph J.O. Kaiser et al.   Nature Communications

Identification of a Tissue-Selective Heat Shock Response Regulatory Network

(2013) Eric Guisbert et al.   PLoS Genetics

Pharmacological Tuning of Heat Shock Protein 70 Modulates Polyglutamine Toxicity and Aggregation

(2012) Sidhartha M. Chafekar et al.   ACS Chemical Biology

An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones

(2012) Anastasia Zhuravleva et al.   CELL

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the GroEL Chaperonin

(2012) Daniel K. Clare et al.   CELL

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

(2012) Heike Rampelt et al.   EMBO JOURNAL

The small heat shock proteins family: The long forgotten chaperones

(2012) C. Garrido et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Lid Domain of Caenorhabditis elegans Hsc70 Influences ATP Turnover, Cofactor Binding and Protein Folding Activity

(2012) Li Sun et al.   PLoS One

Structure of an Intermediate State in Protein Folding and Aggregation

(2012) P. Neudecker et al.   SCIENCE

Ribosome-associated chaperones as key players in proteostasis

(2012) Steffen Preissler et al.   TRENDS IN BIOCHEMICAL SCIENCES

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

(2011) Jurre Hageman et al.   BIOCHEMICAL JOURNAL

Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber

(2011) Nicholai R. Douglas et al.   CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins

(2011) Carien Dekker et al.   EMBO JOURNAL

Small-molecule proteostasis regulators for protein conformational diseases

(2011) Barbara Calamini et al.   Nature Chemical Biology

Mechanics of Hsp70 chaperones enables differential interaction with client proteins

(2011) Rainer Schlecht et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Large Potentials of Small Heat Shock Proteins

(2011) Evgeny V. Mymrikov et al.   PHYSIOLOGICAL REVIEWS

Downregulation of the Hsp90 System Causes Defects in Muscle Cells of Caenorhabditis Elegans

(2011) Andreas M. Gaiser et al.   PLoS One

Biochemical and structural studies on the high affinity of Hsp70 for ADP

(2011) Akihiko Arakawa et al.   PROTEIN SCIENCE

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

Protein folding in the cell: challenges and progress

(2010) Anne Gershenson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Chaperone networks: Tipping the balance in protein folding diseases

(2010) Cindy Voisine et al.   NEUROBIOLOGY OF DISEASE

Purified chaperonin 60 (groEL) interacts with the nonnative states of a multitude of Escherichia coli proteins

(2010) Paul V. Viitanen et al.   PROTEIN SCIENCE

An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans

(2009) Jiou Wang et al.   PLoS Genetics

The interaction network of the chaperonin CCT

(2008) Carien Dekker et al.   EMBO JOURNAL

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

(2008) Alice Y Yam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY