Large Potentials of Small Heat Shock Proteins

HspB8 and Bag3: A new chaperone complex targeting misfolded proteins to macroautophagy

(2014) Serena Carra et al.   Autophagy

Phosphorylation by cyclic AMP-dependent protein kinase inhibits chaperone-like activity of human HSP22 in vitro

(2011) A. A. Shemetov et al.   BIOCHEMISTRY-MOSCOW

The emerging role of HSP20 as a multifunctional protective agent

(2011) H.V. Edwards et al.   CELLULAR SIGNALLING

Small Heat Shock Protein 20 Interacts With Protein Phosphatase-1 and Enhances Sarcoplasmic Reticulum Calcium Cycling

(2011) Jiang Qian et al.   CIRCULATION RESEARCH

Hsp22 (HspB8/H11) knockdown induces sam68 expression and stimulates proliferation of glioblastoma cells

(2011) Suhasini Modem et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Three-Dimensional Structure of α-Crystallin Domain Dimers of Human Small Heat Shock Proteins HSPB1 and HSPB6

(2011) E.V. Baranova et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structures of Xanthomonas Small Heat Shock Protein Provide a Structural Basis for an Active Molecular Chaperone Oligomer

(2011) Eduardo Hilario et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of R120G Disease Mutant of Human αB-Crystallin Domain Dimer Shows Closure of a Groove

(2011) A.R. Clark et al.   JOURNAL OF MOLECULAR BIOLOGY

BAG3 Directly Interacts with Mutated alphaB-Crystallin to Suppress Its Aggregation and Toxicity

(2011) Akinori Hishiya et al.   PLoS One

N-terminal domain of  B-crystallin provides a conformational switch for multimerization and structural heterogeneity

(2011) S. Jehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAG3: a multifaceted protein that regulates major cell pathways

(2011) A Rosati et al.   Cell Death & Disease

Phosphorylated HSP20 modulates the association of thin-filament binding proteins: caldesmon with tropomyosin in colonic smooth muscle

(2010) Sita Somara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

HSPB1, actin filament dynamics, and aging cells

(2010) Bindi M. Doshi et al.   Annals of the New York Academy of Sciences

A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases

(2010) Valeria Crippa et al.   Autophagy

Small heat shock proteins, protein degradation and protein aggregation diseases

(2010) Michel J. Vos et al.   Autophagy

Abnormal interaction of motor neuropathy-associated mutant HspB8 (Hsp22) forms with the RNA helicase Ddx20 (gemin3)

(2010) Xiankui Sun et al.   CELL STRESS & CHAPERONES

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

Small Heat Shock Proteins and Protein-Misfolding Diseases

(2010) Ewa Laskowska et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The structure of native G-actin

(2010) Hui Wang et al.   Cytoskeleton

Dynamic processes that reflect anti-apoptotic strategies set up by HspB1 (Hsp27)

(2010) Catherine Paul et al.   EXPERIMENTAL CELL RESEARCH

Independent evolution of the core domain and its flanking sequences in small heat shock proteins

(2010) Thomas Kriehuber et al.   FASEB JOURNAL

Accumulation of oxidized proteins in Herpesvirus infected cells

(2010) Shomita S. Mathew et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutant HSPB8 causes motor neuron-specific neurite degeneration

(2010) Joy Irobi et al.   HUMAN MOLECULAR GENETICS

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Increased Monomerization of Mutant HSPB1 Leads to Protein Hyperactivity in Charcot-Marie-Tooth Neuropathy

(2010) Leonardo Almeida-Souza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effect of phosphorylated Hsp27 in coronary arteries through actin stabilization

(2010) Aisling A. Robinson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin–proteasome pathways

(2010) Huali Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regions Outside the α-Crystallin Domain of the Small Heat Shock Protein Hsp26 Are Required for Its Dimerization

(2010) Jin Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Differential expression and induction of small heat shock proteins in rat brain and cultured hippocampal neurons

(2010) Britta Bartelt Kirbach et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A novel HSPB1 mutation in an Italian patient with CMT2/dHMN phenotype

(2010) M. Luigetti et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Locally synthesized HSP27 in hepatocytes: Is it possibly a novel strategy against human liver ischemia/reperfusion injury?

(2010) Sun-yi Ye et al.   MEDICAL HYPOTHESES

HspB1 (Hsp 27) Expression and Neuroprotection in the Retina

(2010) Amanda M. O’Reilly et al.   MOLECULAR NEUROBIOLOGY

Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

(2010) Stefan Jehle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutant small heat shock protein B3 causes motor neuropathy: Utility of a candidate gene approach

(2010) S. J. Kolb et al.   NEUROLOGY

Later retinal degeneration following childhood surgical aphakia in a family with recessive CRYAB mutation (p.R56W)

(2010) Arif O. Khan et al.   OPHTHALMIC GENETICS

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function

(2010) Arthur Laganowsky et al.   PROTEIN SCIENCE

The stress-inducible HspB8-Bag3 complex induces the eIF2α kinase pathway: Implications for protein quality control and viral factory degradation?

(2009) Serena Carra   Autophagy

Heat shock protein 27 in neuronal survival and neurite outgrowth

(2009) Danielle E. Read et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caught in the middle: the role of Bag3 in disease: Figure 1

(2009) Andrea K. McCollum et al.   BIOCHEMICAL JOURNAL

Identification of the key structural motifs involved in HspB8/HspB6–Bag3 interaction

(2009) Margit Fuchs et al.   BIOCHEMICAL JOURNAL

Structure and Mechanism of Protein Stability Sensors: Chaperone Activity of Small Heat Shock Proteins

(2009) Hassane S. Mchaourab et al.   BIOCHEMISTRY

A novel mutation (F71L) in αA-Crystallin with defective chaperone-like function associated with age-related cataract

(2009) S.G. Bhagyalaxmi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Thermally induced structural changes of intrinsically disordered small heat shock protein Hsp22

(2009) Alexey S. Kazakov et al.   BIOPHYSICAL CHEMISTRY

The pivotal role of the β7 strand in the intersubunit contacts of different human small heat shock proteins

(2009) Evgeny V. Mymrikov et al.   CELL STRESS & CHAPERONES

The role of Hsp27 and actin in the regulation of movement in human cancer cells responding to heat shock

(2009) Bindi M. Doshi et al.   CELL STRESS & CHAPERONES

Versatility of the small heat shock protein HSPB6 (Hsp20)

(2009) Alim S. Seit-Nebi et al.   CELL STRESS & CHAPERONES

Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton

(2009) Yifeng Jia et al.   CELL STRESS & CHAPERONES

Why proteins without an α-crystallin domain should not be included in the human small heat shock protein family HSPB

(2009) Guido Kappé et al.   CELL STRESS & CHAPERONES

The small heat shock protein, HSPB6, in muscle function and disease

(2009) Catherine M. Dreiza et al.   CELL STRESS & CHAPERONES

Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

(2009) Sergiy Kostenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Activation of the Bone Morphogenetic Protein Receptor by H11Kinase/Hsp22 Promotes Cardiac Cell Growth and Survival

(2009) Xiangzhen Sui et al.   CIRCULATION RESEARCH

Blockade of Hsp20 Phosphorylation Exacerbates Cardiac Ischemia/Reperfusion Injury by Suppressed Autophagy and Increased Cell Death

(2009) Jiang Qian et al.   CIRCULATION RESEARCH

Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma

(2009) Qiaojia Huang et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

HSP27: Mechanisms of Cellular Protection Against Neuronal Injury

(2009) R. Stetler et al.   CURRENT MOLECULAR MEDICINE

The small heat shock protein HSP25 protects astrocytes against stress induced by proteasomal inhibition

(2009) Olaf Goldbaum et al.   GLIA

The co-chaperone BAG3 interacts with the cytosolic chaperonin CCT: New hints for actin folding

(2009) Bianca Fontanella et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Modulation of α-crystallin chaperone activity: A target to prevent or delay cataract?

(2009) Pasupulati Anil Kumar et al.   IUBMB LIFE

Phosphorylation Dependence of Hsp27 Multimeric Size and Molecular Chaperone Function

(2009) David Hayes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms that regulate adaptor binding to  -integrin cytoplasmic tails

(2009) K. R. Legate et al.   JOURNAL OF CELL SCIENCE

An integrin- 4-14-3-3 -paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration

(2009) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-κB activation

(2009) Xiaohong Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Crystal Structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20

(2009) C. Bagnéris et al.   JOURNAL OF MOLECULAR BIOLOGY

Modification and Reorganization of the Cytoprotective Cellular Chaperone Hsp27 during Herpes Simplex Virus Type 1 Infection

(2009) S. S. Mathew et al.   JOURNAL OF VIROLOGY

Protective Effect of Geranylgeranylacetone via Enhancement of HSPB8 Induction in Desmin-Related Cardiomyopathy

(2009) Atsushi Sanbe et al.   PLoS One

Analysis of secondary structure and self-assembly of amelogenin by variable temperature circular dichroism and isothermal titration calorimetry

(2009) Rajamani Lakshminarayanan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Stress proteins and oxidative damage in a renal derived cell line exposed to inorganic mercury and lead

(2009) Alessandra Stacchiotti et al.   TOXICOLOGY

Structural and Functional Diversities between Members of the Human HSPB, HSPH, HSPA, and DNAJ Chaperone Families†

(2008) Michel J. Vos et al.   BIOCHEMISTRY

Heterooligomeric complexes formed by human small heat shock proteins HspB1 (Hsp27) and HspB6 (Hsp20)

(2008) Olesya V. Bukach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Heat shock proteins as molecular targets for intervention in atrial fibrillation

(2008) B. J.J.M. Brundel et al.   CARDIOVASCULAR RESEARCH

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Crystallin proteins and amyloid fibrils

(2008) H. Ecroyd et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heat Shock Protein 20 Interacting With Phosphorylated Akt Reduces Doxorubicin-Triggered Oxidative Stress and Cardiotoxicity

(2008) Guo-Chang Fan et al.   CIRCULATION RESEARCH

Evidence that a Protein Kinase A Substrate, Small Heat-Shock Protein 20, Modulates Myometrial Relaxation in Human Pregnancy

(2008) Elisa K. Tyson et al.   ENDOCRINOLOGY

Small heat shock protein Hsp27 protects myosin S1 from heat-induced aggregation, but not from thermal denaturation and ATPase inactivation

(2008) Denis I. Markov et al.   FEBS LETTERS

A novel mutation in AlphaA-crystallin (CRYAA) caused autosomal dominant congenital cataract in a large Chinese family

(2008) Feng Gu et al.   HUMAN MUTATION

Phosphorylated Heat Shock Protein 27 Represses Growth of Hepatocellular Carcinoma via Inhibition of Extracellular Signal-regulated Kinase

(2008) Rie Matsushima-Nishiwaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Mutation in the Anti-apoptotic Heat Shock Protein 20 Abrogates Its Cardioprotective Effects

(2008) Persoulla Nicolaou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp27 Inhibits Bax Activation and Apoptosis via a Phosphatidylinositol 3-Kinase-dependent Mechanism

(2008) Andrea Havasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HspB8 Participates in Protein Quality Control by a Non-chaperone-like Mechanism That Requires eIF2α Phosphorylation

(2008) Serena Carra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Heat Shock Protein Activity Is Regulated by Variable Oligomeric Substructure

(2008) Justin L. P. Benesch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chibby cooperates with 14-3-3 to regulate β-catenin subcellular distribution and signaling activity

(2008) Feng-Qian Li et al.   JOURNAL OF CELL BIOLOGY

Cell Permeant Peptide Analogues of the Small Heat Shock Protein, HSP20, Reduce TGF-β1-Induced CTGF Expression in Keloid Fibroblasts

(2008) Luciana B. Lopes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Asymmetrical late onset motor neuropathy associated with a novel mutation in the small heat shock protein HSPB1 (HSP27)

(2008) P A James et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Combining Protein-Based IMAC, Peptide-Based IMAC, and MudPIT for Efficient Phosphoproteomic Analysis

(2008) Greg T. Cantin et al.   JOURNAL OF PROTEOME RESEARCH

A clinical phenotype of distal hereditary motor neuronopathy type II with a novel HSPB1 mutation

(2008) Yoshihisa Ikeda et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord

(2008) Georgia Anagnostou et al.   NEUROBIOLOGY OF AGING

Hereditary motor neuropathy and heat shock proteins: A shocking transformation

(2008) C. Gooch et al.   NEUROLOGY

Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2

(2008) H. Houlden et al.   NEUROLOGY

Small heat shock proteins in smooth muscle

(2008) Sonemany Salinthone et al.   PHARMACOLOGY & THERAPEUTICS

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptation of the rat cardiac proteome in response to intensity-controlled endurance exercise

(2008) Jatin G. Burniston   PROTEOMICS

Structure, properties, and functions of the human small heat-shock protein HSP22 (HspB8, H11, E2IG1): A critical review

(2007) Anton A. Shemetov et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion

(2007) Micha M.M. Wilhelmus et al.   NEUROBIOLOGY OF AGING

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

(2007) Paul S. Sharp et al.   NEUROBIOLOGY OF DISEASE