Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells

The emerging role of Acid Sphingomyelinase in autophagy

(2015) Cristiana Perrotta et al.   APOPTOSIS

Glycosphingolipids and cell death: one aim, many ways

(2015) Carmen Garcia-Ruiz et al.   APOPTOSIS

DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma

(2015) Augusto Villanueva et al.   HEPATOLOGY

Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis

(2015) Teodor Kapitanov et al.   Gastroenterology Research and Practice

EIF4EBP1 Overexpression Is Associated with Poor Survival and Disease Progression in Patients with Hepatocellular Carcinoma

(2015) Yin-Lian Cha et al.   PLoS One

20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

(2015) Dong-Gun Kim et al.   Oncotarget

Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers

(2014) Sylvain Lefort et al.   Autophagy

Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells

(2014) Ming-Feng Wei et al.   Autophagy

High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A

(2014) E Gabandé-Rodríguez et al.   CELL DEATH AND DIFFERENTIATION

Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma

(2014) M Corazzari et al.   CELL DEATH AND DIFFERENTIATION

Perfluorooctane sulfonate blocked autophagy flux and induced lysosome membrane permeabilization in HepG2 cells

(2014) Xiao-Feng Yao et al.   FOOD AND CHEMICAL TOXICOLOGY

C2-Ceramide Induces Cell Death and Protective Autophagy in Head and Neck Squamous Cell Carcinoma Cells

(2014) Wenyuan Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis

(2014) Raquel Fucho et al.   JOURNAL OF HEPATOLOGY

Autophagy regulates sphingolipid levels in the liver

(2014) Aikaterini Alexaki et al.   JOURNAL OF LIPID RESEARCH

Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells

(2014) Yunkyung Hong et al.   JOURNAL OF PINEAL RESEARCH

Involvement of autophagy in melatonin-induced cytotoxicity in glioma-initiating cells

(2014) Vanesa Martín et al.   JOURNAL OF PINEAL RESEARCH

Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus

(2014) Beatriz San-Miguel et al.   JOURNAL OF PINEAL RESEARCH

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy and Apoptosis in Hepatocellular Carcinoma Induced by EF25-(GSH)2: A Novel Curcumin Analog

(2014) Tao Zhou et al.   PLoS One

Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells

(2014) Eun-Ryeong Hahm et al.   PROSTATE

Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation

(2014) C Kao et al.   Cell Death & Disease

Retigeric acid B-induced mitophagy by oxidative stress attenuates cell death against prostate cancer cells in vitro

(2013) Yong-qing Liu et al.   ACTA PHARMACOLOGICA SINICA

Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells

(2013) Shu-Er Chow et al.   APOPTOSIS

Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin

(2013) Yue-Mei Feng et al.   Autophagy

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells

(2013) S Carbajo-Pescador et al.   BRITISH JOURNAL OF CANCER

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading

(2013) Anna Fernandez et al.   JOURNAL OF HEPATOLOGY

Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation

(2013) Beatriz de Luxán-Delgado et al.   JOURNAL OF PINEAL RESEARCH

Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells

(2013) Raquel Ordoñez et al.   JOURNAL OF PINEAL RESEARCH

Quercetin Induces Mitochondrial Mediated Apoptosis and Protective Autophagy in Human Glioblastoma U373MG Cells

(2013) Hyeonji Kim et al.   Oxidative Medicine and Cellular Longevity

Deguelin Induces Both Apoptosis and Autophagy in Cultured Head and Neck Squamous Cell Carcinoma Cells

(2013) Yan-li Yang et al.   PLoS One

Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response

(2013) Petra Haberzettl et al.   Redox Biology

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

(2012) Dong Hoon Suh et al.   Annals of the New York Academy of Sciences

Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process

(2012) P Gonzalez et al.   CELL DEATH AND DIFFERENTIATION

Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows In Vivo Antitumor Activity

(2012) S.-H. Yun et al.   CLINICAL CANCER RESEARCH

Involvement of melatonin in autophagy-mediated mouse hepatoma H22 cell survival

(2012) Chang Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melatonin induces autophagy via an mTOR-dependent pathway and enhances clearance of mutant-TGFBIp

(2012) Seung-Il Choi et al.   JOURNAL OF PINEAL RESEARCH

Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells

(2012) Archana Gopalan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells

(2011) Lulu Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation

(2011) Changyou Li et al.   CANCER LETTERS

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor

(2011) Sara Carbajo-Pescador et al.   JOURNAL OF PINEAL RESEARCH

Human Adenovirus Type 5 Induces Cell Lysis through Autophagy and Autophagy-Triggered Caspase Activity

(2011) H. Jiang et al.   JOURNAL OF VIROLOGY

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

(2010) Margaret A. Park et al.   CANCER BIOLOGY & THERAPY

Angiogenesis: multiple masks in hepatocellular carcinoma and liver regeneration

(2010) Ji-An Chen et al.   Hepatology International

Syntaxin 4 Is Required for Acid Sphingomyelinase Activity and Apoptotic Function

(2010) Cristiana Perrotta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus

(2010) María J. Tuñón et al.   JOURNAL OF PINEAL RESEARCH

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

(2010) M. L. Dubocovich et al.   PHARMACOLOGICAL REVIEWS

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Divergent pathways for TNF and C2-ceramide toxicity in HTC hepatoma cells

(2009) Riccardo Autelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Changes in the expression of melatonin receptors induced by melatonin treatment in hepatocarcinoma HepG2 cells

(2009) Sara Carbajo-Pescador et al.   JOURNAL OF PINEAL RESEARCH

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

The Expression and Prognosis of FOXO3a and Skp2 in Human Hepatocellular Carcinoma

(2009) Mudan Lu et al.   PATHOLOGY & ONCOLOGY RESEARCH

Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptors

(2008) Marta Imbesi et al.   BRAIN RESEARCH

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

(2008) Sophie Pattingre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line

(2008) Javier Martín-Renedo et al.   JOURNAL OF PINEAL RESEARCH

Ceramide starves cells to death by downregulating nutrient transporter proteins

(2008) G. G. Guenther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA