Article
Environmental Sciences
Chih-Hao Chiu, Samiraj Ramesh, Po-Hsiang Liao, Wei-Wen Kuo, Ming-Cheng Chen, Chia-Hua Kuo, Chi-Cheng Li, Tso-Fu Wang, Yueh-Min Lin, Yu-Jung Lin, Chih-Yang Huang
Summary: This study found that non-small cell lung cancer (NSCLC) has developed resistance to the chemotherapeutic drug gemcitabine (GEM), and this resistance is associated with alterations in autophagy. The findings suggest that modulating autophagy could be a promising therapeutic approach for drug-resistant lung cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Elisabetta Valentini, Simona D'Aguanno, Marta Di Martile, Camilla Montesano, Virginia Ferraresi, Alexandros Patsilinakos, Manuela Sabatino, Lorenzo Antonini, Martina Chiacchiarini, Sergio Valente, Antonello Mai, Gianni Colotti, Rino Ragno, Daniela Trisciuoglio, Donatella Del Bufalo
Summary: Bcl-2 family anti-apoptotic proteins play a significant role in cancer, and finding new molecules targeting these proteins has therapeutic potential. Through virtual screening and experimental validation, IS20 and IS21 were identified as compounds that can inhibit the activity of Bcl-2 family proteins and have anti-proliferative and pro-apoptotic effects on various tumors.
Article
Biochemistry & Molecular Biology
Sudjit Luanpitpong, Montira Janan, Juthamas Yosudjai, Jirarat Poohadsuan, Pithi Chanvorachote, Surapol Issaragrisil
Summary: Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma with poor prognosis due to drug resistance. Overexpression of antiapoptotic Bcl-xL and depletion of proapoptotic Bax contribute to acquired resistance to bortezomib (BTZ) in MCL cells. High Bcl-xL and low Bax levels are associated with poor prognosis in MCL patients. Targeting these proteins using BH3 mimetics and Bax activators may be a promising strategy to overcome drug resistance in MCL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Jiazhe Liu, Yongzhi Liu, Hongchang Li, Chuangchao Wei, Anwei Mao, Weiyan Liu, Gaofeng Pan
Summary: The study found that Polyphyllin D (PD) can induce autophagy in breast cancer cells through activation of the JNK1/Bcl-2 pathway, and increase PD-induced cell apoptosis by inhibiting autophagy, thus achieving anti-tumor effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jie Yu, Lin Han, Feng Yang, Mingliang Zhao, Hong Zhou, Linwang Hu
Summary: The high expression of SOCS5 is associated with poor prognosis and resistance to TMZ in GBM. TMZ treatment increases the expression of SOCS5 and induces autophagy, which is mediated by SOCS5. Mechanistically, SOCS5 enhances the transcription of Bcl-2. Knockdown of SOCS5 reduces TMZ chemoresistance in GBM cells by inhibiting Bcl-2-mediated autophagy.
Article
Biochemistry & Molecular Biology
Md Maksudul Alam, Janmaris Marin Fermin, Patrick T. Spiller, Chaning Burnett, Xiaohua Rong, Tara Moore-Medlin, Caden O. Maxwell, Alok R. Khandelwal, Cherie-Ann O. Nathan
Summary: This study reveals that rapalogs induce non-apoptotic autophagy-dependent cell death in HPV-negative mutTP53 HNSCC via the ULK1 pathway. In a mouse tumor model, RAD001 significantly reduces tumor volume without inducing apoptosis, accompanied by an increase in autophagy levels.
MOLECULAR CARCINOGENESIS
(2022)
Article
Chemistry, Multidisciplinary
Xue-qi Liu, Ling Jiang, Yuan-yuan Li, Yue-bo Huang, Xue-ru Hu, Wei Zhu, Xian Wang, Yong-gui Wu, Xiao-ming Meng, Xiang-ming Qi
Summary: Wogonin has been shown to alleviate glomerulopathy and podocyte injury in diabetic kidney disease (DKD) by regulating the Bcl-2-mediated crosstalk between autophagy and apoptosis. The study also demonstrated the inhibitory effects of wogonin on cellular damage and apoptosis induced by high glucose, as well as its promotion of autophagy in podocytes.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Dentistry, Oral Surgery & Medicine
Qilin Li, Jing Wang, Xinyao Meng, Weimin Chen, Jiexiong Feng, Jing Mao
Summary: This study aimed to identify prognostic autophagy-related genes and lncRNAs for predicting clinical outcomes in head and neck squamous cell carcinoma (HNSCC). Differentially expressed ARGs and AR-lncRNAs were identified, and a high-risk group was found to have significantly shorter overall survival (OS). Additionally, autophagy-related pathways were mainly enriched in the high-risk group.
Article
Cell Biology
Nicholas Nikesitch, Patricia Rebeiro, Lye Lin Ho, Srinivasa Pothula, Xin Maggie Wang, Tiffany Khong, Hazel Quek, Andrew Spencer, Cheok Soon Lee, Tara L. Roberts, Silvia C. W. Ling
Summary: The study found that the upregulation of CMA in Bz-resistant MM cells and the inhibition of CMA can sensitize the resistant cells to Bz. The protein levels of LAMP2A, the rate-limiting factor of the CMA pathway, were significantly increased in MM patients resistant to Bz and in the Bz-resistant cell line model. Inhibition of CMA sensitizes Bz-resistant cells to Bz and the combination of CMA inhibition and Bz had a more cytotoxic effect on myeloma cells than Bz alone.
Article
Oncology
Yu-Yan Lan, Ying-Hui Chen, Cheng Liu, Kuo-Lung Tung, Yen-Ting Wu, Sheng-Chieh Lin, Chin-Han Wu, Hong-Yi Chang, Yung-Chia Chen, Bu-Miin Huang
Summary: This study found that paclitaxel induces apoptosis in HNSCC cells by activating the JNK signaling pathway and inhibiting the protein controlling mitochondrial membrane potential. Paclitaxel also activates a series of caspase proteins to promote cell apoptosis. These findings may serve as a mechanistic basis for designing more effective paclitaxel-combining regimens to treat HNSCC.
Article
Oncology
Zhiwei Chen, Hyoung Jae Lee, Hangun Kim, Sayeon Cho, Kwonseop Kim
Summary: This study reveals the role of delta-catenin in the migration and invasion of prostate cancer cells and demonstrates that it promotes these processes through the suppression of autophagy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Yigeng Feng, Hongwen Cao, Wenyang Zhao, Lei Chen, Dan Wang, Renjie Gao
Summary: miR-143 plays an important role in the sensitivity of prostate cancer cells to abiraterone acetate. Upregulation of miR-143 can enhance the sensitivity of prostate cancer cells to abiraterone acetate, and induce cell apoptosis by inhibiting p-JNK and increasing p-Bcl2 expression.
Article
Chemistry, Multidisciplinary
Jie Yang, Zhen-dong Li, Chang-yan Hou, Zi-yu Li, Qiang Li, Shen-yu Miao, Qing Zhang, Xiao-ying Zhang, Xiao-feng Zhu, Jian-wei Jiang
Summary: EM-2 inhibited the proliferation of Huh-7 hepatocellular carcinoma cells by activating the MAPK pathway and inducing apoptosis through the JNK pathway. Additionally, it blocked autophagic flux by inhibiting autolysosome maturation.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Plant Sciences
Qi Xie, Xinmei Fan, Yonghong Han, Bao-Xiang Wu, Bao Zhu
Summary: The results of this study demonstrate that daphnoretin can inhibit the proliferation of breast cancer cells by arresting the cell cycle and inducing apoptosis, which is associated with the PI3K/AKT pathway.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Donglin Yang, Liujun He, Shuiqing Ma, Shiqiang Li, Yajun Zhang, Chunsheng Hu, Jiuhong Huang, Zhigang Xu, Dianyong Tang, Zhongzhu Chen
Summary: Compound 6d, a spiroindoline compound, inhibits CRC growth by acting as an inhibitor of Bcl-2 and inducing caspase 3-mediated intrinsic apoptosis. Caspase 3 activation by compound 6d directly cleaves HDAC6, with cleavage occurring at D1088 in the DMAD-S motif. Compound 6d-induced apoptosis promotes autophagy initiation by disrupting the interaction between Bcl-2 and Beclin 1, resulting in the accumulation of ubiquitinated proteins and reduction of autophagic flux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
