Linaclotide

Linaclotide: A Novel Approach to the Treatment of Irritable Bowel Syndrome

(2011) Terri M Wensel et al.   ANNALS OF PHARMACOTHERAPY

Pharmacology of the New Treatments for Lower Gastrointestinal Motility Disorders and Irritable Bowel Syndrome

(2011) M Camilleri   CLINICAL PHARMACOLOGY & THERAPEUTICS

Two Randomized Trials of Linaclotide for Chronic Constipation

(2011) Anthony J. Lembo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

(2010) Robert W. Busby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation

(2010) Jeffrey M. Johnston et al.   GASTROENTEROLOGY

Efficacy of Linaclotide for Patients With Chronic Constipation

(2010) Anthony J. Lembo et al.   GASTROENTEROLOGY

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

(2010) Alexander P. Bryant et al.   LIFE SCIENCES

Current management strategies and therapeutic targets in chronic constipation

(2010) Anton Emmanuel   Therapeutic Advances in Gastroenterology

Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain

(2009) h. eutamene et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation

(2008) Jeffrey M Johnston et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY