Linaclotide: A Novel Approach to the Treatment of Irritable Bowel Syndrome

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

(2010) Robert W. Busby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Taking a Lesson From Microbial Diarrheagenesis in the Management of Chronic Constipation

(2010) Adil E. Bharucha et al.   GASTROENTEROLOGY

T1817 Results From the Randomized Withdrawal Period of a Phase 3 Clinical Trial of Linaclotide in Chronic Constipation

(2010) Jeffrey M. Johnston et al.   GASTROENTEROLOGY

286 Efficacy and Safety of Once Daily Linaclotide Administered Orally for 12-Weeks in Patients With Chronic Constipation: Results From 2 Randomized, Double-Blind, Placebo-Controlled Phase 3 Trials

(2010) Anthony Lembo et al.   GASTROENTEROLOGY

Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation

(2010) Jeffrey M. Johnston et al.   GASTROENTEROLOGY

Immunologic Basis of Graft Rejection and Tolerance Following Transplantation of Liver or Other Solid Organs

(2010) Alberto Sánchez–Fueyo et al.   GASTROENTEROLOGY

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

(2010) Alexander P. Bryant et al.   LIFE SCIENCES

Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases

(2010) Lincoln R. Potter   PHARMACOLOGY & THERAPEUTICS

An Evidence-Based Position Statement on the Management of Irritable Bowel Syndrome

(2009)   AMERICAN JOURNAL OF GASTROENTEROLOGY

T1273 Time to Onset of Linaclotide Effect On the Bowel Habits in Patients with Chronic Constipation: Results from a Phase 2B Study

(2009) Jeffrey M. Johnston et al.   GASTROENTEROLOGY

157 Effect of Linaclotide On IBS-C Symptoms in the First Week of Treatment: Results from a Phase 2B Study

(2009) Anthony J. Lembo et al.   GASTROENTEROLOGY

236 Global Endpoints in IBS Clinical Trials: Results from a Phase 2B Study of Linaclotide

(2009) Jeffrey M. Johnston et al.   GASTROENTEROLOGY

Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain

(2009) h. eutamene et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Linaclotide Significantly Improved Bowel Habits and Relieved Abdominal Symptoms in Adults with Chronic Constipation: Data from a Large 4-Week, Randomized, Double-Blind, Placebo-Controlled Study

(2008) Anthony J. Lembo et al.   GASTROENTEROLOGY