Review
Medicine, Research & Experimental
Fanglin Niu, Yi Yu, Zhuozhuo Li, Yuanyuan Ren, Zi Li, Qiang Ye, Ping Liu, Chenshuang Ji, Lu Qian, Yuyan Xiong
Summary: Arginase plays a crucial role in cancer by regulating tumor growth and metastasis through mechanisms such as L-arginine metabolism and tumor immune microenvironment. Targeting arginase has emerged as an attractive approach for cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Amrutha Menon, Noraini Abd-Aziz, Kanwal Khalid, Chit Laa Poh, Rakesh Naidu
Summary: This review focuses on the role of miRNA in cancer, therapeutic approaches with miRNAs, and effective delivery into the system. Patents and ongoing clinical trials for miRNA therapy are also summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Hai Zhao, Shuangshuang Song, Junwei Ma, Zhiyong Yan, Hongwei Xie, Ying Feng, Shusheng Che
Summary: CD47 is a protein that is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. It modulates cellular phagocytosis, determines the lifespan of erythrocytes, regulates immune cell activation, and manipulates synaptic pruning during neuronal development. Recently, CD47 has been identified as a novel target for cancer immunotherapy. This review discusses the diverse functions of CD47, its role in immune system homeostasis, and its potential therapeutic roles against cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Dermatology
M. Perez, A. Chakraborty, L. S. Lau, N. B. B. Mohammed, C. J. Dimitroff
Summary: This review discusses the role of glycans in melanoma, specifically focusing on the specialized function of GCNT2 in melanoma pathogenesis. Aberrant expression of GCNT2 may serve as a predictive marker and potential therapeutic target in melanoma.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Kuei-Yen Tsai, Yu-Jia Chang, Chien-Yu Huang, G. M. Shazzad Hossain Prince, Hsin-An Chen, Precious Takondwa Makondi, Ying-Rou Shen, Po-Li Wei
Summary: This study found that heavily fucosylated glycans (HFGs) are overexpressed in colorectal cancer tissues compared to normal tissues. Treatment with anti-HFG monoclonal antibody showed cytotoxic effects in colorectal cancer cells and inhibited tumor growth in a xenograft mouse model. HFGs could be a potential therapeutic target for colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Surendra Kumar Sagar
Summary: This review focuses on the function of miR-106b and its downstream targets in cancer, providing insights into how miR-106b regulates cancer cell proliferation, migration, invasion, and metastasis by modulating tumor suppressor genes. The potential of miR-106b as a candidate for detection, diagnosis, and prognosis assessment in different cancer types is highlighted.
Review
Oncology
Guoqiang Liu, Minggang Zhu, Mingrui Zhang, Feng Pan
Summary: Prostate cancer (PCa) is a highly heterogeneous disease driven by gene alterations and microenvironmental influences. IGF-1 and its receptor IGF-1R have emerged as vital drivers in the development of PCa. Inhibitory reagents targeting IGF-1/IGF-1R signaling have shown promise in limiting cancer development, but further research and clinical trials are needed.
Review
Biochemistry & Molecular Biology
Yanjiao Zhang, Xinyi Fang, Jiahua Wei, Runyu Miao, Haoran Wu, Kaile Ma, Jiaxing Tian
Summary: PDX-1 plays a crucial role in pancreatic development and the pathogenesis of diabetes. Overexpression of PDX-1 regulates pancreatic development and promotes beta-cell differentiation and insulin secretion. The absence of PDX-1 increases susceptibility to diabetes.
Article
Oncology
Maotuan Huang, Fuxiu Zhong, Mingyuan Chen, Lingju Hong, Weihong Chen, Xiahenazi Abudukeremu, Feifei She, Yanling Chen
Summary: Through bioinformatics analysis, five key genes of GBC were identified, among which CEP55 was found to be overexpressed in GBC and associated with advanced TNM stage, differentiation grade, and poorer survival. Inhibition of CEP55 in GBC cells resulted in decreased proliferation, cell cycle arrest, DNA damage, and increased apoptosis. CEP55 inhibition in vivo attenuated tumor growth and promoted apoptosis in GBC cells. The tumor suppressor effect of CEP55 knockdown is mechanistically associated with dysregulation of the AKT and ERK signaling networks.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ping Zhao, Dewei Jiang, Yunchao Huang, Ceshi Chen
Summary: EphA2, a receptor tyrosine kinase overexpressed in human breast cancers, plays important roles in malignant breast progression and has become a promising therapeutic target for breast cancer treatment.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Review
Immunology
Chenran Yue, Sheng Gao, Shuting Li, Zhouhang Xing, Hengrong Qian, Ying Hu, Wenqian Wang, Chunyan Hua
Summary: Co-inhibitory receptors (IRs) play a crucial role in maintaining immune homeostasis and treating cancer. Recent studies have shown that T cell immunoglobulin and ITIM domain (TIGIT), a novel IR, also plays an important role in autoimmune diseases. Blocking the TIGIT pathway exacerbates autoimmune diseases, while enhancing TIGIT function alleviates autoimmune reactions. Therefore, exploring TIGIT as a therapeutic target in autoimmune diseases is of great significance.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Muhammad Tufail, Changxin Wu
Summary: Cancers such as lung, breast, colon, and prostate have been associated with dysregulation of SRPKs. Inhibition of SRPKs has shown promise in reducing cancer growth and survival, making them potential therapeutic targets. Ongoing research is focused on developing small molecule inhibitors for SRPKs, identifying specific SRPKs relevant to different cancer types, and exploring RNA interference (RNAi) as a means to target SRPKs. Additionally, researchers are investigating the use of SRPK inhibitors in combination with other cancer therapies to improve treatment outcomes. However, further research is needed to fully comprehend the role of SRPKs in cancer and determine the most effective targeting approaches.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Paulina Terlecka, Pawel Krawczyk, Anna Grenda, Janusz Milanowski
Summary: Various molecular abnormalities in the MET gene have been identified in NSCLC, with dysregulation playing a significant role in resistance to EGFR TKIs. Clinical trials focused on MET inhibitors have shown efficacy in NSCLC patients with skipping mutations in exon 14 of the MET gene, highlighting the importance of personalized therapy in this population.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Camilla Pecoraro, Beatrice Faggion, Beatrice Balboni, Daniela Carbone, Godefridus J. Peters, Patrizia Diana, Yehuda G. Assaraf, Elisa Giovannetti
Summary: Pancreatic cancer is a challenging malignancy characterized by late diagnosis and chemoresistance, highlighting the need for new therapeutic targets. GSK3 beta, a conserved serine/threonine kinase, plays a crucial role in the development and progression of pancreatic cancer, offering potential as a target for overcoming chemoresistance. Studies on GSK3 beta inhibitors in preclinical models show promising results, indicating its significance in cancer treatment.
DRUG RESISTANCE UPDATES
(2021)
Review
Oncology
Pouriya Sameti, Maryam Tohidast, Mohammad Amini, Seyedeh Zahra Bahojb Mahdavi, Souzan Najafi, Ahad Mokhtarzadeh
Summary: Numerous studies have shown that miRNAs are dysregulated in various human cancers and play significant roles in tumorigenesis. In particular, the aberrant expression of miR-182 has been linked to malignancies. It functions as a dual-role regulator by directly or indirectly regulating the expression of numerous genes and modulating signaling pathways involved in tumor progression. This review highlights the effects of miR-182 dysregulation on the signaling pathways involved in tumorigenesis, emphasizing its potential as a therapeutic and diagnostic target.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Yuan Peng, Hongming Miao, Shuang Wu, Weiwen Yang, Yue Zhang, Ganfeng Xie, Xiong Xie, Jianjun Li, Chunmeng Shi, Lilin Ye, Wei Sun, Liting Wang, Houjie Liang, Juanjuan Ou
Article
Gastroenterology & Hepatology
Yinghui Huang, Jie Zhou, Shenglin Luo, Yang Wang, Jintao He, Peng Luo, Zelin Chen, Tao Liu, Xu Tan, Juanjuan Ou, Hongming Miao, Houjie Liang, Chunmeng Shi
Article
Chemistry, Multidisciplinary
Lei Long, Xu Tan, Shenglin Luo, Chunmeng Shi
NEW JOURNAL OF CHEMISTRY
(2017)
Article
Cell Biology
Zelin Chen, Xin Wang, Taotao Jin, Yu Wang, Christopher S. Hong, Li Tan, Tingyu Dai, Liao Wu, Zhengping Zhuang, Chunmeng Shi
CELL DEATH & DISEASE
(2017)
Article
Multidisciplinary Sciences
Wei Xiang, Rongchen Shi, Xia Kang, Xuan Zhang, Peng Chen, Lili Zhang, Along Hou, Rui Wang, Yuanyin Zhao, Kun Zhao, Yingzhe Liu, Yue Ma, Huan Luo, Shenglan Shang, Jinyu Zhang, Fengtian He, Songtao Yu, Lixia Gan, Chunmeng Shi, Yongsheng Li, Wei Yang, Houjie Liang, Hongming Miao
NATURE COMMUNICATIONS
(2018)
Article
Chemistry, Multidisciplinary
Yang Wang, Xingyun Liao, Jianguo Sun, Bin Yi, Shenglin Luo, Tao Liu, Xu Tan, Dengqun Liu, Zelin Chen, Xin Wang, Chunmeng Shi
Article
Cell & Tissue Engineering
Rui Zuo, Yanqiu Wang, Jie Li, Junlong Wu, Wenkai Wang, Bin Li, Chao Sun, Ziwen Wang, Chunmeng Shi, Yue Zhou, Minghan Liu, Chao Zhang
Article
Cell Biology
Peng Luo, Chi Zhang, Fengying Liao, Long Chen, Zhenyu Liu, Lei Long, Zhongyong Jiang, Yawei Wang, Ziwen Wang, Zujuan Liu, Hongming Miao, Chunmeng Shi
CELL COMMUNICATION AND SIGNALING
(2019)
Article
Multidisciplinary Sciences
Ziwen Wang, Zelin Chen, Zhongyong Jiang, Peng Luo, Lang Liu, Yu Huang, Huilan Wang, Yu Wang, Lei Long, Xu Tan, Dengqun Liu, Taotao Jin, Yawei Wang, Yang Wang, Fengying Liao, Chi Zhang, Long Chen, Yibo Gan, Yunsheng Liu, Fan Yang, Chunji Huang, Hongming Miao, Jieping Chen, Tianmin Cheng, Xiaobing Fu, Chunmeng Shi
NATURE COMMUNICATIONS
(2019)
Article
Oncology
Huilan Wang, Ziwen Wang, Yu Huang, Yue Zhou, Xiaowu Sheng, Qingzhi Jiang, Yawei Wang, Peng Luo, Min Luo, Chunmeng Shi
FRONTIERS IN ONCOLOGY
(2020)
Article
Pharmacology & Pharmacy
Long Chen, Fengying Liao, Zhongyong Jiang, Chi Zhang, Ziwen Wang, Peng Luo, Qingzhi Jiang, Jie Wu, Qing Wang, Min Luo, Xueru Li, Yu Leng, Le Ma, Gufang Shen, Zelin Chen, Yu Wang, Xu Tan, Yibo Gan, Dengqun Liu, Yunsheng Liu, Chunmeng Shi
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Emergency Medicine
Fengying Liao, Long Chen, Peng Luo, Zhongyong Jiang, Zelin Chen, Ziwen Wang, Chi Zhang, Yu Wang, Jintao He, Qing Wang, Yawei Wang, Lang Liu, Yu Huang, Huilan Wang, Qingzhi Jiang, Min Luo, Yibo Gan, Yunsheng Liu, Yang Wang, Jie Wu, Wentao Xie, Zhuo Cheng, Yali Dai, Jialun Li, Zujuan Liu, Fan Yang, Chunmeng Shi
Article
Oncology
Peng Luo, Qingzhi Jiang, Qiang Fang, Yawei Wang, Ziwen Wang, Jing Yang, Xu Tan, Weibing Li, Chunmeng Shi
AMERICAN JOURNAL OF CANCER RESEARCH
(2019)
Article
Chemistry, Multidisciplinary
Xu Tan, Shenglin Luo, Lei Long, Yu Wang, Dechun Wang, Shengtao Fang, Qin Ouyang, Yongping Su, Tianmin Cheng, Chunmeng Shi
ADVANCED MATERIALS
(2017)
Article
Nanoscience & Nanotechnology
Zhangyou Yang, Shenglin Luo, Yiping Zeng, Chunmeng Shi, Rong Li
ACS APPLIED MATERIALS & INTERFACES
(2017)
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
