Article
Oncology
Na Wang, Min Chen, Zhen Ni, Ting Li, Jiaoxia Zeng, Guofang Lu, Jiaojiao Wang, Jian Zhang, Siran Wu, Yongquan Shi
Summary: The HDAC6/HNF4 alpha loop regulated by miR-1 plays a critical role in gastric intestinal metaplasia (IM). Blocking the activation of this loop could be a potential approach to preventing BA-induced gastric IM or even gastric cancer (GC).
Article
Gastroenterology & Hepatology
Hong-Yan Chen, Yi Hu, Xin-Bo Xu, Yan-An Zhou, Nian-Shuang Li, Cong He, Chuan Xie, Nong-Hua Lu, Yin Zhu
Summary: The study revealed that H. pylori infection increases ACVR1 expression, promoting gastric intestinal metaplasia by regulating CDX2, which is a crucial step in H. pylori carcinogenesis.
Article
Oncology
Sara Ribeirinho-Soares, Diana Padua, Ana Luisa Amaral, Elvia Valentini, Daniela Azevedo, Cristiana Marques, Rita Barros, Filipa Macedo, Patricia Mesquita, Raquel Almeida
Summary: In stage II CRC patients, low MUC2 expression, in combination with high CDX2 expression, absence of SOX2 or MMR-proficiency, is associated with worse prognosis, while none of these biomarkers showed prognostic value overall. Patients with low MUC2 expression derived significant benefit from adjuvant chemotherapy.
Article
Genetics & Heredity
Yalun Zhu, Alexa Hryniuk, Tanya Foley, Bradley Hess, David Lohnes
Summary: Loss-of-function mutations in APC contribute to malignant progression of colorectal polyps, while the absence of Cdx2 is associated with more aggressive subtypes of colorectal cancer. Simultaneous loss of Cdx1 and Cdx2 in mice leads to an increase in intestinal polyps. In SW480 colorectal cancer cells, loss of Cdx2 affects the Notch signaling pathway and results in EphrinB1 loss, potentially influencing colorectal cancer through a Notch-dependent mechanism.
Article
Gastroenterology & Hepatology
Xiaofang Yang, Ting Ye, Li Rong, Hong Peng, Jin Tong, Xiao Xiao, Xiaoqiang Wan, Jinjun Guo
Summary: GATA4 is upregulated and can form a positive feedback loop with CDX2 to trans-activate MUC2 in GIM. NF-Kappa B signaling is involved in the upregulation of GATA4 by chenodeoxycholic acid.
Article
Gastroenterology & Hepatology
Harshabad Singh, Kyungsik Ha, Jason L. Hornick, Shariq Madha, Paloma Cejas, Kunal Jajoo, Pratik Singh, Paz Polak, Hwajin Lee, Ramesh A. Shivdasani
Summary: The study found that Barrett's esophagus has epigenome fingerprints of both stomach and intestinal characteristics, with individual cells expressing genes from both tissues. This reflects simultaneous chromatin access at enhancers, leading to tissue and subclonal heterogeneity in cell states.
Article
Neurosciences
Cristiana Barone, Mariachiara Buccarelli, Francesco Alessandrini, Miriam Pagin, Laura Rigoldi, Irene Sambruni, Rebecca Favaro, Sergio Ottolenghi, Roberto Pallini, Lucia Ricci-Vitiani, Paolo Malatesta, Silvia K. Nicolis
Summary: The transcription factor Sox2 plays a crucial role in the maintenance of cancer stem cells (CSC) in brain gliomas. Deletion of Sox2 leads to cell proliferation arrest and derepression of multiple genes, which are involved in glioma CSC maintenance. Overexpression of certain derepressed genes such as Ebf1, Hey2, Zfp423, and Cdkn2b significantly reduces cell proliferation in vitro and tumorigenesis in vivo, pointing to them as potential therapeutic targets.
Article
Multidisciplinary Sciences
Takahiro Koide, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yoshihiro Kakeji, Takashi Aoi
Summary: This study demonstrated that the overexpression of CDX2 in human gastric organoids induced intestinal metaplasia, providing insights into the mechanisms of intestinal metaplasia and carcinogenesis in human gastric mucosa.
Article
Biochemistry & Molecular Biology
Shuya Ohira, Yuki Yokoi, Tokiyoshi Ayabe, Kiminori Nakamura
Summary: This study reports a rapid and efficient method for generating transgenic enteroids by transferring genes into isolated crypts of the small intestine. The transgenic enteroids containing all lineages of intestinal epithelial cells were obtained quickly and maintained their intestinal function.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Paulius Jonaitis, Limas Kupcinskas, Juozas Kupcinskas
Summary: Gastric cancer is a common cause of mortality worldwide, with intestinal metaplasia considered a key factor in its development. Recent research has identified various molecular alterations in intestinal metaplasia, some of which show strong associations with the disease and potential for prevention and treatment, though study homogeneity is a key limiting factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Douglas Tjandra, Rita A. Busuttil, Alex Boussioutas
Summary: Gastric adenocarcinoma is a common and lethal cancer, often asymptomatic at early stages. Gastric intestinal metaplasia (GIM) is a premalignant lesion associated with chronic inflammation, predisposing to gastric cancer. This article summarizes the best clinical practice in the diagnosis, assessment and management of GIM, as well as opportunities for precision predictions in the future.
Article
Gastroenterology & Hepatology
Theresa H. Nguyen, Mimi C. Tan, Yan Liu, Massimo Rugge, Aaron P. Thrift, Hashem B. El-Serag
Summary: Hispanic and African American patients have a higher risk of gastric intestinal metaplasia detected by upper endoscopy biopsy compared to non-Hispanic white patients. This increased risk is partially independent of H. pylori infection.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Oncology
Shuangshuang Fang, Yuhan Fu, Sijing Du, Lin Wang, Xiangli Qing, Xiaoying Luo, Gengqing Song, Yang Yang, Wei Wei
Summary: This study conducted a meta-analysis to evaluate the value of EGGIM in the histological assessment of gastric intestinal metaplasia. The results showed that EGGIM is highly consistent with OLGIM, and patients with EGGIM(5-10) have a higher risk for early gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Daisuke Suzuki, Keisuke Sasaki, Soichiro Kumamoto, Keisuke Tanaka, Hidehiko Ogawa
Summary: This study reveals the stage-specific and dynamic changes of gene expression in the mouse mural trophectoderm (mTE) during implantation. The results show that down-regulation of Cdx2 and up-regulation of differentiation marker genes in the mTE are crucial for implantation progression. Overexpressing Cdx2 in the TE represses mTE differentiation and the up-regulation of cell adhesion- and migration-related genes, leading to abnormal blastocyst outgrowth and implantation progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Biao Song, Tingting Li, Yi Zhang, Qi Yang, Bei Pei, Yun Liu, Jieyu Wang, Gang Dong, Qin Sun, Shanshan Fan, Xuejun Li
Summary: This study identified and verified the role of ferroptosis-related genes (FRGs) in gastric intestinal metaplasia (IM) through bioinformatics analysis. The results showed that HMOX1 may be a diagnostic biomarker and therapeutic target for IM.
FRONTIERS IN GENETICS
(2023)
