Grg3/TLE3 and Grg1/TLE1 Induce Monohormonal Pancreatic β-Cells While Repressing α-Cell Functions

Pancreatic α-Cell Specific Deletion of Mouse Arx Leads to α-Cell Identity Loss

(2013) Crystal L. Wilcox et al.   PLoS One

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

(2013) Ashleigh E. Schaffer et al.   PLoS Genetics

The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and  -cell differentiation

(2012) D. E. Metzger et al.   DEVELOPMENT

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine

(2012) Maria Cristina Nostro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

(2011) Sangeeta Dhawan et al.   DEVELOPMENTAL CELL

Transcriptomes of the major human pancreatic cell types

(2011) C. Dorrell et al.   DIABETOLOGIA

Context-specific  -to- -cell reprogramming by forced Pdx1 expression

(2011) Y.-P. Yang et al.   GENES & DEVELOPMENT

Nkx2.2 repressor complex regulates islet  -cell specification and prevents  -to- -cell reprogramming

(2011) J. B. Papizan et al.   GENES & DEVELOPMENT

Ectopic PDX-1 Expression Directly Reprograms Human Keratinocytes along Pancreatic Insulin-Producing Cells Fate

(2011) Michal Mauda-Havakuk et al.   PLoS One

NKX6.1 Promotes PDX-1-Induced Liver to Pancreatic β-Cells Reprogramming

(2010) Shiraz Gefen-Halevi et al.   Cellular Reprogramming

Dynamic expression ofgroucho-related genesGrg1andGrg3in foregut endoderm and antagonism of differentiation

(2010) Pilar Santisteban et al.   DEVELOPMENTAL DYNAMICS

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Rfx6 directs islet formation and insulin production in mice and humans

(2010) Stuart B. Smith et al.   NATURE

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

How to make β cells?

(2009) Malgorzata Borowiak et al.   CURRENT OPINION IN CELL BIOLOGY

Single pancreatic beta cells co-express multiple islet hormone genes in mice

(2009) H. Katsuta et al.   DIABETOLOGIA

Expression of Groucho/TLE proteins during pancreas development

(2008) Brad G Hoffman et al.   BMC DEVELOPMENTAL BIOLOGY

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE