Editorial Material
Cell Biology
S. Joseph Endicott, Richard A. Miller
Summary: PTEN is a negative regulator of the INS-PI3K-AKT pathway and plays a critical role in metabolism and cell growth. It is frequently mutated in cancer, but overexpression of PTEN extends lifespan in mice. Our recent study demonstrated that PTEN activates chaperone-mediated autophagy (CMA) and selectively degrades metabolic enzymes to suppress glycolysis and fatty acid synthesis. This suggests that PTEN-mediated CMA activation could modulate health and metabolism.
Article
Biochemistry & Molecular Biology
Marianna Carinci, Beatrice Testa, Matteo Bordi, Giacomo Milletti, Massimo Bonora, Laura Antonucci, Caterina Ferraina, Marta Carro, Mukesh Kumar, Donatella Ceglie, Franziska Eck, Roberta Nardacci, Francois le Guerroue, Stefania Petrini, Maria E. Soriano, Ignazio Caruana, Valentina Doria, Maria Manifava, Camille Peron, Matteo Lambrughi, Valeria Tiranti, Christian Behrends, Elena Papaleo, Paolo Pinton, Carlotta Giorgi, Nicholas T. Ktistakis, Franco Locatelli, Francesca Nazio, Francesco Cecconi
Summary: The study reveals the crucial role of COPII vesicle-related protein TFG in autophagy induction, affecting ULK1 puncta number and localization, isolation membrane formation, and correct dynamics of LC3B and ATG proteins association for proper omegasome and autophagosome formation. The interaction between TFG and ATG8 protein LC3C through a canonical LIR motif is essential for TFG's activity in autophagy, favoring LC3C-ULK1 binding. Overall, TFG is identified as a molecular scaffold linking the early secretion pathway to autophagy.
Article
Plant Sciences
Ping Wang, Natalie M. Clark, Trevor M. Nolan, Gaoyuan Song, Olivia G. Whitham, Ching-Yi Liao, Christian Montes-Serey, Diane C. Bassham, Justin W. Walley, Yanhai Yin, Hongqing Guo
Summary: This study reveals a previously unknown mechanism by which FER negatively regulates autophagy through TOR.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Zhi Hu, Zhipan Yang, Yi Zhang, Aihong Zhang, Qingtao Lu, Ying Fang, Congming Lu
Summary: Flowering time is a critical agronomic trait that determines crop yield and adaptability, and the homeostasis of Hd1 protein in rice is regulated by the nuclear autophagy pathway. Loss of autophagy function leads to Hd1 accumulation and delayed flowering. This study reveals a new mechanism by which Hd1 protein homeostasis is regulated by autophagy.
Article
Biochemistry & Molecular Biology
James L. Shen, Tina M. Fortier, Yan G. Zhao, Ruoxi Wang, Margit Burmeister, Eric H. Baehrecke
Summary: Mutations in Vps13D gene lead to defects in autophagy, clearance of mitochondria, and human movement disorders. Vps13D functions in a pathway downstream of Vmp1 and upstream of Marf/Mfn2, playing a crucial role in regulating mitochondria and endoplasmic reticulum contact.
Article
Multidisciplinary Sciences
Di Liu, Zhiyao Zhao, Yuanchu She, Lei Zhang, Xiangtian Chen, Ling Ma, Jun Cui
Summary: The study identifies TRIM14 as an epigenetic regulator that modulates the immune response by inhibiting the autophagic degradation of the histone demethylase KDM4D. TRIM14 deficiency in dendritic cells impairs the expression of proinflammatory cytokines and protects mice from autoimmune inflammation, suggesting TRIM14 as a potential therapeutic target for inflammation-related diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Mouliganesh Sekar, Kavitha Thirumurugan
Summary: Obesity is a disease caused by an imbalance of adipose tissue function, and autophagy and adipogenesis are important mechanisms in its regulation. Autophagy regulates adipocyte differentiation and lipid metabolism, while adipogenesis and lipolysis are associated with the occurrence of obesity.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Cell Biology
Binbin Huang, Lingling Jin, Luodan Zhang, Xiaolin Cui, Zhen Zhang, Yongqi Lu, Lujia Yu, Tonghui Ma, He Zhang
Summary: Aquaporin-8 (AQP8) mediates H2O2 transport and regulates autophagy in follicular granulosa cells, playing an important role in follicular atresia. AQP8 deficiency decreases H2O2 concentration, thereby affecting cell death and autophagy in granulosa cells, which may be related to ovarian insufficiency.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Clement Bodineau, Mercedes Tome, Sarah Courtois, Ana S. H. Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Perez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad del Socorro Murdoch, Victor H. Villar, Raul Duran
Summary: In this study, the authors demonstrate that reactivation of AMPK can inhibit glutamine-dependent activation of mTORC1 and glutamoptosis, revealing a dual metabolic connection between glutamine metabolism and mTORC1 through two pathways. This finding has significant implications for the design of future therapeutic strategies for diseases such as cancer.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Katrin Panzitt, Martin Wagner
Summary: The liver serves as a central metabolic hub that coordinates nutritional inputs and metabolic outputs. FXR in the liver and intestine plays a crucial role in regulating postprandial nutrient disposal. Aside from classical roles, FXR also has effects on amino acid, protein metabolism, autophagic turnover, and inflammation, which are less studied. Additionally, understanding of how FXR signaling is affected by posttranslational modifications and different isoforms is important for potential pharmaceutical targeting in clinical applications.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Ching-Tien Lee, Cheng-Fang Hsieh, Jiz-Yuh Wang
Summary: This study demonstrates that BPA induces neurotoxicity through various pathways, including apoptosis and autophagy defects, ultimately leading to neuronal death and degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Raquel Iglesias-Fernandez, Jesus Vicente-Carbajosa
Summary: This mini-review presents current advances in autophagy in seeds, highlighting its participation in the normal course of seed development from embryogenesis to germination, as well as its involvement in controlling seed dormancy and germination.
Article
Cell Biology
Baocai Liu, Yinliang Lu, Tingting Zhang, Xinyue Yu, Qian Wang, Yunbo Chi, Shunzi Jin, Guanghui Cheng
Summary: CMTM7 facilitates autophagosome formation and promotes subsequent multistage autophagic flux, as well as increases the activity of the ATG14L-linked VPS34 complex. Knockdown of CMTM7 enhances tumor growth, indicating its significant role in autophagy and tumorigenicity.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Cell Biology
Liyan Gong, Kaihua Wang, Mengcheng Wang, Ronggui Hu, Huaguang Li, Daming Gao, Moubin Lin
Summary: The study identified the CUL5-ASB6 complex as a mediator of p62 ubiquitination and degradation, with overexpression of ASB6 inhibiting cell proliferation by reducing p62 protein level and affecting autophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Plant Sciences
Maria Esther Perez-Perez, Stephane D. Lemaire, Jose L. Crespo
Summary: Autophagy is a crucial cellular pathway that maintains cellular homeostasis by removing damaged or unnecessary components. ATG4, as a key enzyme, plays an important role in regulating the biogenesis of autophagosomes.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Flavie Strappazzon, Anthea Di Rita, Angelo Peschiaroli, Pier Paolo Leoncini, Franco Locatelli, Gerry Melino, Francesco Cecconi
CELL DEATH AND DIFFERENTIATION
(2020)
Correction
Biochemistry & Molecular Biology
Flavie Strappazzon, Anthea Di Rita, Angelo Peschiaroli, Pier Paolo Leoncini, Franco Locatelli, Gerry Melino, Francesco Cecconi
CELL DEATH AND DIFFERENTIATION
(2020)
Editorial Material
Cell Biology
Sos Gronbaek Holdgaard, Valentina Cianfanelli, Francesco Cecconi
Editorial Material
Biochemistry & Molecular Biology
Francesco Cecconi
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Biochemistry & Molecular Biology
Luca Simula, Mauro Corrado, Benedetta Accordi, Anthea Di Rita, Francesca Nazio, Ylenia Antonucc, Arianna Di Danie, Federico Caicci, Ignazio Caruana, Maria Eugenia Soriano, Martina Pigazzi, Franco Locatelli, Francesco Cecconi, Silvia Campello
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Developmental Biology
Giacomo Meneghetti, Tatjana Skobo, Martina Chrisam, Camilla Maria Fontana, Nicola Facchinello, Francesca Nazio, Francesco Cecconi, Paolo Bonaldo, Luisa Dalla Valle
Article
Physiology
Flavia Messina, Francesco Cecconi, Carlo Rodolfo
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Immunology
Sara Mandatori, Ilenia Pacella, Vincenzo Marzolla, Caterina Mammi, Donatella Starace, Fabrizio Padula, Laura Vitiello, Andrea Armani, Carmine Savoia, Maurizio Taurino, Daniela De Zio, Claudia Giampietri, Silvia Piconese, Francesco Cecconi, Massimiliano Caprio, Antonio Filippini
FRONTIERS IN IMMUNOLOGY
(2020)
Correction
Biochemistry & Molecular Biology
Luca Simula, Mauro Corrado, Benedetta Accordi, Anthea Di Rita, Francesca Nazio, Ylenia Antonucci, Arianna Di Daniele, Federico Caicci, Ignazio Caruana, Maria Eugenia Soriano, Martina Pigazzi, Franco Locatelli, Francesco Cecconi, Silvia Campello
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Genetics & Heredity
Marina Macchiaiolo, Paola Sabrina Buonuomo, Gerarda Mastrogiorgio, Matteo Bordi, Beatrice Testa, Gerrit Weber, Emanuele Bellacchio, Marco Tartaglia, Francesco Cecconi, Andrea Bartuli
MOLECULAR GENETICS AND METABOLISM REPORTS
(2020)
Article
Cell Biology
Katharina Bell, Ines Rosignol, Elena Sierra-Filardi, Natalia Rodriguez-Muela, Carsten Schmelter, Francesco Cecconi, Franz Grus, Patricia Boya
CELL DEATH DISCOVERY
(2020)
Review
Biochemistry & Molecular Biology
Daniel J. Klionsky, Giulia Petroni, Ravi K. Amaravadi, Eric H. Baehrecke, Andrea Ballabio, Patricia Boya, Jose Manuel Bravo-San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M. K. Choi, Mary E. Choi, Charleen T. Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan Dikic, Zvulun Elazar, Eeva-Liisa Eskelinen, Gian Maria Fimia, David A. Gewirtz, Douglas R. Green, Malene Hansen, Marja Jaattela, Terje Johansen, Gabor Juhasz, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T. Ktistakis, Sharad Kumar, Carlos Lopez-Otin, Kay F. Macleod, Frank Madeo, Jennifer Martinez, Alicia Melendez, Noboru Mizushima, Christian Munz, Josef M. Penninger, Rushika M. Perera, Mauro Piacentini, Fulvio Reggiori, David C. Rubinsztein, Kevin M. Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans-Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A. Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Lorenzo Galluzzi, Federico Pietrocola
Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.
Editorial Material
Cell Biology
Emiliano Maiani, Giacomo Milletti, Francesco Cecconi
Summary: AMBRA1 is a key scaffold protein that regulates early autophagosome formation, cell growth, and G1/S phase transition, and its deficiency is associated with neurodevelopmental defects and cancer. By controlling the expression of D-type cyclins, AMBRA1 plays a crucial role in maintaining genome integrity during DNA replication and represents a novel mechanism of cell cycle regulation interconnected with genomic stability in development and cancer.
Article
Cell Biology
Matteo Bordi, Rossella De Cegli, Beatrice Testa, Ralph A. Nixon, Andrea Ballabio, Francesco Cecconi
Summary: The study compiled a comprehensive list of 604 genes involved in the autophagy pathway, categorizing them into main groups and sub-groups based on their functions and sub-cellular localization. They also curated shorter sub-lists for predicting autophagy activation and lysosomal biogenesis, and validated some transcriptional targets using Real-time PCR. The authors demonstrated the utility of their autophagy gene list in RNA-sequencing analysis.
CELL DEATH & DISEASE
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
C. Cirotti, S. Rizza, M. F. Allega, G. Claps, J. H. Lee, B. Benassi, D. Barila, C. Robert, J. S. Stamler, F. Cecconi, T. T. Paull, G. Filomeni
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
