Review
Cell Biology
Sadie VanHorn, Samantha A. Morris
Summary: Lineage tracing and fate mapping are two disciplines for tracking cells and their progeny, with lineage tracing focusing on identifying progeny and fate maps showing embryo development. Recent genomic technologies have enabled high-resolution reconstruction of lineage relationships. Fate maps, however, offer spatial information often lost in lineage reconstruction.
DEVELOPMENTAL CELL
(2021)
Review
Biochemistry & Molecular Biology
Mingze Yao, Tinglin Ren, Yuanqing Pan, Xiaoqing Xue, Rong Li, Lei Zhang, Yuhang Li, Ke Huang
Summary: This review presents the progress of the latest CbLT (CRISPR-based Lineage Tracing) and discusses the current limitations and potential technical pitfalls in their application and other emerging concepts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Developmental Biology
Steffen Wolf, Yinan Wan, Katie McDole
Summary: Advances in light microscopy, labelling strategies and computational methods have enabled detailed investigations into cell fates, and when combined with genomics and single-cell transcriptomics, developmental biology can describe embryo formation in unprecedented detail. The review discusses different strategies and applications for lineage tracing in live-imaging data, as well as outlining software methodologies for various cell-tracking challenges.
Article
Immunology
Moujtaba Y. Kasmani, Ryan Zander, H. Kay Chung, Yao Chen, Achia Khatun, Martina Damo, Paytsar Topchyan, Kaitlin E. Johnson, Darya Levashova, Robert Burns, Ulrike M. Lorenz, Vera L. Tarakanova, Nikhil S. Joshi, Susan M. Kaech, Weiguo Cui
Summary: Using single-cell RNA and TCR sequencing, researchers investigated the developmental relationships and fate decisions of CD8(+) T cells during chronic infection. They found substantial clonal and phenotypic diversity, and identified a subset of intermediate cells that can differentiate into terminal effector and exhausted cells. Type I IFN and IRF7 were found to drive exhaustion, while Zeb2 was critical for effector cell generation. TCR avidity correlated with exhausted fate and SHP-1 selectively restricted accumulation of low-avidity effector cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Laleh Haghverdi, Leif S. Ludwig
Summary: The concept of cell fate is about the future identity of a cell and its daughters through cell differentiation and division. Understanding and manipulating cell fate has been a long-standing goal in developmental and regenerative biology. Recent advancements in single-cell genomics and integrative lineage-tracing approaches have provided insights into the molecular features that can predict cell fate.
Editorial Material
Oncology
Eunmi Lee, Yibin Kang
Summary: The combination of single-cell lineage tracing and RNA sequencing has opened up unprecedented opportunities for prospectively exploring metastatic dynamics. In a pancreatic cancer model, Simeonov et al. developed the macsGESTALT lineage recording system, revealing that hybrid EMT states and S100 expression are associated with increased metastatic abilities.
Review
Cardiac & Cardiovascular Systems
Tao Wang, Xinzhe Chen, Kai Wang, Jie Ju, Xue Yu, Shaocong Wang, Cuiyun Liu, Kun Wang
Summary: The Cre-loxP-mediated genetic lineage tracing system is crucial for tracking the fate of single-cell progeny or cell populations. Understanding the hierarchy of cardiac progenitor cells helps to uncover cell fate and origin in cardiac development. Several prospective Cre-loxP-based lineage-tracing systems have been utilized to precisely analyze the fate determination and developmental characteristics of different cardiac cell types.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cell Biology
Jingjing Zhou, Xiangxiang Jiang, Haowei Wu, Lianjun Zhang, Min Chen, Zhiming Shen, Xudong Guo, Hongmei Wang, Fei Gao
Summary: In this study, the cell fate of Foxl2-expressing cells in fetal ovaries was analyzed using lineage tracing and single-cell transcriptomics. It was found that these cells give rise to granulosa cells, theca-interstitial cells, and stromal cells at later developmental stages. This study provides important insights into the differentiation of somatic cells in ovary development.
Review
Oncology
Calum Gabbutt, Nicholas A. Wright, Ann-Marie Baker, Darryl Shibata, Trevor A. Graham
Summary: The dynamical process of cell division that maintains homeostasis in the human body cannot be observed directly. Instead, it is measured through somatic genetic or epigenetic mutations in tissues. Mathematical analysis of somatic clone sizes provides quantitative information on cell birth, death, and replacement rates. This review explores the use of different somatic mutation types for lineage tracing in human tissues, introduces mathematical concepts for inferring dynamic information from clone size data, and discusses the implications of this approach for understanding homeostasis and cancer development.
JOURNAL OF PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Michael Spencer Chapman, Anna Maria Ranzoni, Brynelle Myers, Nicholas Williams, Tim H. H. Coorens, Emily Mitchell, Timothy Butler, Kevin J. Dawson, Yvette Hooks, Luiza Moore, Jyoti Nangalia, Philip S. Robinson, Kenichi Yoshida, Elizabeth Hook, Peter J. Campbell, Ana Cvejic
Summary: By reconstructing a phylogenetic tree of blood development in healthy human fetuses, it was found that individual haematopoietic progenitors acquire multiple somatic mutations by 18 weeks after conception. The data also support a hypoblast origin of the extra-embryonic mesoderm and primitive blood in humans.
Review
Biochemistry & Molecular Biology
Maria Figueres-Onate, Rebeca Sanchez-Gonzalez, Laura Lopez-Mascaraque
Summary: Understanding the strategies used to study cell lineages in the brain and their role in deciphering functional clonal relationships among neural cells; future perspectives will focus on studying cell heterogeneity and the origins of different cell lineages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Entomology
Amy Campbell, Neil Audsley, Gordon Port
Summary: This study investigated the effects of metaldehyde on Deroceras reticulatum, finding that a lower concentration of metaldehyde may be as effective as a higher concentration, but more slugs were able to recover from metaldehyde poisoning at lower concentrations.
Article
Environmental Sciences
Niels J. J. de Winter, Sterre van Sikkeleras, Barbara Goudsmit-Harzevoort, Wim Boer, Lennart de Nooijer, Gert-Jan Reichart, Philippe Claeys, Rob Witbaard
Summary: Growth experiments are important for studying the effect of environmental factors on biogenic calcifiers. This study investigates the use of strontium labeling in mollusc growth experiments and finds that high doses of dissolved strontium can create reproducible peaks in shell-incorporated strontium. Accurate reconstructions of growth rates require frequent spiking with high doses of strontium.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Engineering, Biomedical
Hyuna Kim, Anna Wirasaputra, Farnaz Mohammadi, Aritra Nath Kundu, Jennifer A. E. Esteves, Laura M. M. Heiser, Aaron S. S. Meyer, Shelly R. R. Peyton
Summary: Breast cancer is a major cause of cancer-related deaths worldwide, primarily due to metastasis and dormancy. Dormancy, a prolonged period between tumor resection and relapse, poses significant challenges in current therapies. To overcome this, a live cell lineage approach is used to track and distinguish dormant cells from proliferative and dying cells in various in vitro microenvironments. The study reveals that the proportion of long-term quiescent cells is regulated by both intrinsic and extrinsic factors, with the highest percentage found in 3D collagen gels. This approach is expected to benefit the study of dormant tumor cells for biologists and bioengineers in the dormancy community.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Vasiliki Kostiou, Huairen Zhang, Michael W. J. Hall, Philip H. Jones, Benjamin A. Hall
Summary: A study found that using transgenic mouse cell tracking is an effective way to study progenitor cell dynamics, requiring three parameters to describe growth dynamics. By comparing different analysis strategies, an approximate Bayesian computation-based approach was determined to be the most efficient.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
J. David Lambert, Adam B. Johnson, Chelsea N. Hudson, Amanda Chan
Article
Cell Biology
Morgan Q. Goulding, J. David Lambert
CURRENT OPINION IN GENETICS & DEVELOPMENT
(2016)
Article
Biochemistry & Molecular Biology
Jeremy S. Rabinowitz, Xin Yi Chan, Evan P. Kingsley, Yingli Duan, J. David Lambert
Review
Biochemistry & Molecular Biology
J. David Lambert
Article
Developmental Biology
Jeremy S. Rabinowitz, J. David Lambert
Article
Cell Biology
S. Zachary Swartz, Xin Yi Chan, J. David Lambert
DEVELOPMENT GENES AND EVOLUTION
(2008)
Article
Developmental Biology
Xin Yi Chan, J. David Lambert
DEVELOPMENTAL BIOLOGY
(2011)
Article
Zoology
J. David Lambert, Xin Yi Chan, Barbara Spiecker, Hyla C. Sweet
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2010)
Article
Developmental Biology
Maey Gharbiah, Ayaki Nakamoto, Adam B. Johnson, J. David Lambert, Lisa M. Nagy
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Longjun Wu, Kailey E. Ferger, J. David Lambert
MOLECULAR BIOLOGY AND EVOLUTION
(2019)
Article
Multidisciplinary Sciences
Adam B. Johnson, Nina S. Fogel, J. David Lambert
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Longjun Wu, Laurel S. Hiebert, Marleen Klann, Yale Passamaneck, Benjamin R. Bastin, Stephan Q. Schneider, Mark Q. Martindale, Elaine C. Seaver, Svetlana A. Maslakova, J. David Lambert
NATURE COMMUNICATIONS
(2020)
Article
Evolutionary Biology
J. David Lambert
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
(2008)
Article
Evolutionary Biology
Evan P. Kingsley, Xin Yi Chan, Yingli Duan, J. David Lambert
EVOLUTION & DEVELOPMENT
(2007)