Review
Multidisciplinary Sciences
Hideki Izumi, Yasuhiko Kaneko, Akira Nakagawara
Summary: Research on neuroblastoma uses neuroblastoma cell lines as an ACD model and demonstrates the conservation of ACD in human cancer cells, with MYCN involvement in cell division fate. Human neuroblastoma cells prove to be an ideal model system for studying the mechanism of ACD.
Article
Biochemistry & Molecular Biology
Francesco Meghini, Torcato Martins, Qian Zhang, Nicolas Loyer, Michelle Trickey, Yusanjiang Abula, Hiroyuki Yamano, Jens Januschke, Yuu Kimata
Summary: A functional centrosome is crucial for animal development and physiology. In addition to regulating centriole duplication, ubiquitin-mediated proteolysis plays a vital role in controlling the precise regulation of centrosome. The research conducted on Drosophila demonstrates that APC/C-Fzr controls the levels of Spd2 to affect neural stem cell-specific asymmetric PCM recruitment and microtubule nucleation at interphase centrosomes. Furthermore, APC/C-Fzr-dependent Spd2 degradation facilitates the accumulation of Polo-dependent Spd2 phosphorylation for PCM recruitment.
Review
Cell Biology
Jose Blanco-Ameijeiras, Pilar Lozano-Fernandez, Elisa Marti
Summary: Centrosomes are essential for organizing the cytoskeleton and controlling chromosome segregation during cell division. They also play a role in cilium regulation and signal reception. Understanding the process of centrosome duplication and centriole maturation is crucial for understanding cell division and cilium function.
JOURNAL OF CELL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Hongyu Liu, Huixin Luo, Qi Xue, Shan Qin, Shuang Qiu, Shibo Liu, Jian Lin, Jie P. Li, Peng R. Chen
Summary: This study presents a method for the detection and quantification of cell-cell interactions using photocatalytic labeling, which allows the labeling of interacting cells and provides insights into immune responses and immunotherapy development.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Genetics & Heredity
Dipen S. Mehta, Hala Zein-Sabatto, Pearl Ryder, Jina Lee, Dorothy A. Lerit
Summary: This study found that centrocortin (cen) is not essential for centriole duplication but contributes to centrosome separation in Drosophila embryos, based on time-lapse recordings of rapid syncytial divisions.
G3-GENES GENOMES GENETICS
(2022)
Article
Developmental Biology
Junnan Fang, Dorothy A. Lerit
Summary: This study investigates the post-transcriptional regulation of the Drosophila Pericentrin-like protein (PLP) mRNA. The research reveals that the CPEB ortholog Orb interacts with Plp mRNA to promote polyadenylation and enhance PLP protein expression. Loss of Orb leads to decreased PLP levels, compromising PCM scaffolding and centrosome function, which results in genomic instability and embryonic lethality. Moreover, overexpression of PLP restores centrosome scaffolding and rescues cell division defects caused by Orb depletion.
Article
Biology
Mikito Owa, Brian Dynlacht
Summary: The study demonstrates a kinetochore-independent role of CENP-E in removing PCM1 from centrosomes in late S/early G(2) phase, leading to aberrant Plk1 localization, phosphorylation, and destabilization of centrosomes, ultimately resulting in cell division defects. Additionally, cells from microcephaly patients with mutations in CENPE show centrosome and cell division abnormalities, shedding light on the connection between centrosomal defects and microcephaly.
COMMUNICATIONS BIOLOGY
(2021)
Review
Cell Biology
Zizhu Li, Ying Yi Zhang, Haomiao Zhang, Jiaxuan Yang, Yongze Chen, Hezhe Lu
Summary: Asymmetric cell division is a fundamental process for generating cell diversity and maintaining stem cell populations. In tumor cells, asymmetric division is closely associated with cancer initiation and progression, leading to intratumoral heterogeneity. Studying the relationship between ACD and cancer may provide new approaches for combating cancer heterogeneity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Daniela Londono-Vasquez, Katherine Rodriguez-Lukey, Susanta K. Behura, Ahmed Z. Balboula
Summary: Through studying mouse oocytes, researchers discovered a subset of microtubule organizing centers called mcMTOCs that regulate the positioning of the spindle and faithful chromosome segregation during meiosis I. They found that mcMTOCs work in conjunction with F-actin to balance the forces exerted on the spindle and ensure its central anchoring and timely migration.
DEVELOPMENTAL CELL
(2022)
Article
Engineering, Biomedical
Yanqun Li, Jianhui Yue, Yuan Liu, Jun Wu, Min Guan, Di Chen, Haobo Pan, Xiaoli Zhao, William W. Lu
Summary: The study revealed that strontium promotes osteogenic differentiation of mesenchymal stem cells and balances stemness maintenance and osteogenic differentiation through asymmetric cell division. Strontium activates noncanonical Wnt signaling to regulate cell division and enhance osteogenic differentiation.
ACTA BIOMATERIALIA
(2021)
Article
Multidisciplinary Sciences
Junfeng Liu, Virginija Cvirkaite-Krupovic, Diana P. Baquero, Yunfeng Yang, Qi Zhang, Yulong Shen, Mart Krupovic
Summary: Archaeal virus STSV2 interferes with the cell cycle of its host Sulfolobus islandicus, leading to giant cell formation and asymmetric division. The CRISPR-Cas system plays a key role in defending against the virus. This study sheds light on how archaeal viruses manipulate host cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Jeroen de Keijzer, Alejandra Freire Rios, Viola Willemsen
Summary: In multicellular organisms, cell proliferation and specialization are crucial for development, and in plants, these processes heavily rely on the spatial organization of cells within tissues. Plant cells maintain their relative positions at the moment of division, and the developmental trajectories of daughter cells are often determined by division plane positioning in the parental cell. The moss Physcomitrium patens serves as a suitable model system for studying division plane control, as it undergoes a transition from a simple to a complex three-dimensional body plan formation, involving specific mechanisms such as polarity protein complexes and cytoskeletal structures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Raeann Goering, Ankita Arora, Megan C. Pockalny, J. Matthew Taliaferro
Summary: RNA molecules are localized to specific subcellular regions through interactions between RNA regulatory elements and RNA binding proteins. The localization mechanisms are conserved across different cell types with different morphologies, indicating the presence of broadly similar mechanisms. In the study, it was found that mRNA encoding ribosomal proteins were strongly localized to the basal pole of human intestinal epithelial cells, and the same motifs were also sufficient to drive RNA localization to the neurites of mouse neuronal cells.
Article
Genetics & Heredity
Emmanuel Gallaud, Laurent P. Richard-Parpaillon, Laetitia Bataille, Aude P. Pascal, Mathieu Metivier, Vincent P. Archambault, Regis Giet
Summary: Stem cells ensure tissue development and repair through asymmetric division and mitotic progression. Polo kinase activity levels are regulated by phosphorylation from Aurora A and Aurora B kinases, which determine the duration of cell division and play a crucial role in stem cell polarization and tumor prevention.
Article
Biochemistry & Molecular Biology
John A. Fozard, Man Yu, William Bezodis, Jie Cheng, Jamie Spooner, Catherine Mansfield, Jordi Chan, Enrico Coen
Summary: Plant cells exhibit polarity, and this polarity can be coordinated through mechanical stresses. In cotyledons, there are two coordinated biases in planar polarity: mediolateral and proximodistal. These biases are not significantly affected by applied tension.
Article
Biochemistry & Molecular Biology
J. David Lambert, Adam B. Johnson, Chelsea N. Hudson, Amanda Chan
Article
Cell Biology
Morgan Q. Goulding, J. David Lambert
CURRENT OPINION IN GENETICS & DEVELOPMENT
(2016)
Article
Biochemistry & Molecular Biology
Jeremy S. Rabinowitz, Xin Yi Chan, Evan P. Kingsley, Yingli Duan, J. David Lambert
Review
Biochemistry & Molecular Biology
J. David Lambert
Article
Developmental Biology
Jeremy S. Rabinowitz, J. David Lambert
Article
Cell Biology
S. Zachary Swartz, Xin Yi Chan, J. David Lambert
DEVELOPMENT GENES AND EVOLUTION
(2008)
Article
Cell Biology
Xin Yi Chan, J. David Lambert
DEVELOPMENT GENES AND EVOLUTION
(2014)
Article
Zoology
J. David Lambert, Xin Yi Chan, Barbara Spiecker, Hyla C. Sweet
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2010)
Article
Developmental Biology
Maey Gharbiah, Ayaki Nakamoto, Adam B. Johnson, J. David Lambert, Lisa M. Nagy
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Longjun Wu, Kailey E. Ferger, J. David Lambert
MOLECULAR BIOLOGY AND EVOLUTION
(2019)
Article
Multidisciplinary Sciences
Adam B. Johnson, Nina S. Fogel, J. David Lambert
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Longjun Wu, Laurel S. Hiebert, Marleen Klann, Yale Passamaneck, Benjamin R. Bastin, Stephan Q. Schneider, Mark Q. Martindale, Elaine C. Seaver, Svetlana A. Maslakova, J. David Lambert
NATURE COMMUNICATIONS
(2020)
Article
Evolutionary Biology
J. David Lambert
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
(2008)
Article
Evolutionary Biology
Evan P. Kingsley, Xin Yi Chan, Yingli Duan, J. David Lambert
EVOLUTION & DEVELOPMENT
(2007)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)