期刊
DEVELOPMENTAL CELL
卷 56, 期 1, 页码 7-21出版社
CELL PRESS
DOI: 10.1016/j.devcel.2020.10.021
关键词
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资金
- National Institute of General Medical Sciences [R01 GM126112]
- Silicon Valley Community Foundation, Chan Zuckerberg Initiative grant [CZF2019-002423]
- Children's Discovery Initiative grant [CDI-SP-2019-847]
- Allen Distinguished Investigator Award
- Paul G. Allen Frontiers Group advised grant of the Paul G. Allen Family Foundation
- Vallee Scholar Award
- Sloan Research Fellowship
- New York Stem Cell Foundation Robertson Investigator Award
- NIH [5T32GM007067-46]
Lineage tracing and fate mapping are two disciplines for tracking cells and their progeny, with lineage tracing focusing on identifying progeny and fate maps showing embryo development. Recent genomic technologies have enabled high-resolution reconstruction of lineage relationships. Fate maps, however, offer spatial information often lost in lineage reconstruction.
Lineage tracing and fate mapping, overlapping yet distinct disciplines to follow cells and their progeny, have evolved rapidly over the last century. Lineage tracing aims to identify all progeny arising from an individual cell, placing them within a lineage hierarchy. The recent emergence of genomic technologies, such as single-cell and spatial transcriptomics, has fostered sophisticated new methods to reconstruct lineage relationships at high resolution. In contrast, fate maps, schematics showing which parts of the embryo will develop into which tissue, have remained relatively static since the 1970s. However, fate maps provide spatial information, often lost in lineage reconstruction, that can offer fundamental mechanistic insight into development. Here, we broadly review the origins of fate mapping and lineage tracing approaches. We focus on the most recent developments in lineage tracing, permitted by advances in single-cell genomics. Finally, we explore the current potential to leverage these new technologies to synthesize high-resolution fate maps and discuss their potential for interrogating development at new depths.
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