Gene editing in human development: ethical concerns and practical applications

A global observatory for gene editing

(2018) Sheila Jasanoff et al.   NATURE

CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein

(2017) Lichun Tang et al.   MOLECULAR GENETICS AND GENOMICS

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

(2017) Marta N. Shahbazi et al.   NATURE

U.S. attitudes on human genome editing

(2017) Dietram A. Scheufele et al.   SCIENCE

A pluripotent stem cell-based model for post-implantation human amniotic sac development

(2017) Yue Shao et al.   Nature Communications

Correction of β-thalassemia mutant by base editor in human embryos

(2017) Puping Liang et al.   Protein & Cell

Addressing the ethical issues raised by synthetic human entities with embryo-like features

(2017) John Aach et al.   eLife

Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro

(2016) Quan Zhou et al.   Cell Stem Cell

Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing

(2016) Kenya Sato et al.   Cell Stem Cell

The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion

(2016) Kotaro Sasaki et al.   DEVELOPMENTAL CELL

Self-organization of the in vitro attached human embryo

(2016) Alessia Deglincerti et al.   NATURE

Reconstitution in vitro of the entire cycle of the mouse female germ line

(2016) Orie Hikabe et al.   NATURE

A developmental coordinate of pluripotency among mice, monkeys and humans

(2016) Tomonori Nakamura et al.   NATURE

Applications of CRISPR technologies in research and beyond

(2016) Rodolphe Barrangou et al.   NATURE BIOTECHNOLOGY

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

(2015) Naoko Irie et al.   CELL

Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

(2015) Kotaro Sasaki et al.   Cell Stem Cell

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

(2015) Puping Liang et al.   Protein & Cell

Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells

(2014) Yuxuan Wu et al.   CELL RESEARCH

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS