Article
Biochemistry & Molecular Biology
Romina M. Rodriguez, Marina Colom-Pellicer, Jordi Blanco, Enrique Calvo, Gerard Aragones, Miquel Mulero
Summary: This study found that seasonal variations have an impact on hepatic glucose and lipid metabolism, suggesting a potential relationship with metabolic diseases. Furthermore, the consumption of procyanidin may modulate the photoperiod-dependent changes in glucose and lipid metabolism.
Article
Food Science & Technology
Ivan Escobar-Martinez, Veronica Arreaza-Gil, Begona Muguerza, Anna Arola-Arnal, Francisca Isabel Bravo, Cristina Torres-Fuentes, Manuel Suarez
Summary: This study found that circadian rhythms, diet, and gender are key factors influencing the bioavailability of phenolic compounds.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Chemistry, Physical
Dan-Yang Wang, Bo-Li Nie, Hui-Jing Li, Wei-Wei Zhang, Yan-Chao Wu
Summary: The mixture of GSPE and Tween-80 as an eco-friendly corrosion inhibitor shows excellent inhibition performance for mild steel in 1M hydrochloric acid, with the inhibitory effect verified through various experimental methods. The study found that this mixture can enhance the corrosion inhibition of mild steel, achieving an inhibition rate of 96.48%, and the mechanism of action was determined through adsorption isotherms and surface analysis.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Agriculture, Multidisciplinary
Federico J. Berli, Rodrigo Alonso, Richard P. Pharis, Ruben Bottini
Summary: The application of GA(5), GA(4), and GA(4/7) to grape berry bunches over a 3-year field experiment showed an increase in berry numbers per bunch at harvest, leading to improved berry quality for winemaking, thus proving to be a viable viticultural practice for enhancing wine grape production and quality.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Oncology
Ka-Na Lin, Wei Zhao, Shi-Ying Huang, Hao Li
Summary: The study revealed that GSPE inhibits the proliferation of HL-60/ADR cells through induction of apoptosis in a dose-dependent manner via the Bax/Bcl-2 caspase-3/9 signaling pathway.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Chemistry, Applied
Meng Xu, Xiaoling Chen, Zhiqing Huang, Daiwen Chen, Mingzhou Li, Jun He, Hong Chen, Ping Zheng, Jie Yu, Yuheng Luo, Bing Yu
Summary: The study found that dietary grape seed proanthocyanidin extract (GSPE) supplementation can improve meat quality, muscle fiber characteristics, and antioxidant capacity in finishing pigs. By increasing certain nutrient content and promoting specific protein expressions, GSPE enhances the overall nutritional value of pork.
Article
Biochemistry & Molecular Biology
Antonio J. Cortes-Espinar, Nestor Ibarz-Blanch, Jorge R. Soliz-Rueda, Enrique Calvo, Francisca Isabel Bravo, Miquel Mulero, Javier Avila-Roman
Summary: Disruptions of the light/dark cycle and unhealthy diets can lead to oxidative stress. Grape seed proanthocyanidin extract (GSPE) has antioxidant properties and has shown positive effects in regulating circadian disruptions. This study examined the impact of GSPE administration on the liver oxidant system of rats undergoing a sudden photoperiod shift. The results indicate that GSPE improved the antioxidant response under specific photoperiod conditions, suggesting its potential in treating circadian-related disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Antonio J. Cortes-Espinar, Nestor Ibarz-Blanch, Jorge R. Soliz-Rueda, Beatrice Bonafos, Christine Feillet-Coudray, Francois Casas, Francisca Isabel Bravo, Enrique Calvo, Javier Avila-Roman, Miquel Mulero
Summary: Polyphenols play a key role in regulating circadian rhythms, while the cafeteria diet disrupts liver biological rhythm and increases ROS production. This study investigated the effects of grape seed proanthocyanidin extract (GSPE) on restoring the antioxidant balance and circadian rhythm in rats fed a cafeteria diet. GSPE treatment recovered the disrupted circadian rhythm, increased the peak expression of Sod1, and corrected altered hepatic metabolites. The timing of GSPE administration also showed a chronotherapeutic effect on its antioxidant properties.
Article
Pharmacology & Pharmacy
Yiyun Song, Hui Yu, Qiaoling Sun, Fei Pei, Qing Xia, Zhaoli Gao, Xianhua Li
Summary: Grape seed proanthocyanidin extract (GSPE) can maintain the balance between mitochondrial biogenesis and dynamics by negatively regulating p66Shc expression, and it has a renal protective effect in diabetic kidney disease (DKD).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Kangliang Sheng, Guanghui Zhang, Xiaowei Kong, Jingmin Wang, Wanmeng Mu, Yongzhong Wang
Summary: Encapsulating grape seed proanthocyanidin extract (GSPE) using materials such as sodium alginate (SA) can improve stability and release efficiency, effectively immobilizing GSPE in polymeric microcapsules for controlled release. Research has shown that microcapsules made with SA-methyl cellulose (MC) and SA-hydroxypropyl methylcellulose (HPMC) exhibit higher thermal stability, making them suitable for maintaining GSPE content and release efficiency.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Jessica Bassetto Carra, Ricardo Luis Nascimento de Matos, Ana Paula Novelli, Rene Oliveira do Couto, Fabio Yamashita, Marcos Alessandro dos Santos Ribeiro, Eduardo Cesar Meurer, Waldiceu Aparecido Verri, Rubia Casagrande, Sandra Regina Georgetti, Nilton Syogo Arakawa, Marcela Maria Baracat
Summary: Novel microcapsules containing grape peel by-product extract were successfully obtained using complex coacervation and spray-drying. Factors such as feed rate, drying temperature, and airflow rate were found to influence the microencapsulation process. The interaction between polyphenols in the extract and polymers played a key role in enhancing thermal stability and reducing material loss during the spray-drying process.
Article
Chemistry, Multidisciplinary
Ana Paula da Fonseca Machado, Antonio Montes, Diego Valor
Summary: This study investigated the co-precipitation of ethanol extract from grape residue with polyvinylpyrrolidone using sub- and supercritical CO2 technology. The effects of pressure and temperature on the process and particle characteristics were evaluated. The results showed that higher pressures and temperatures resulted in better precipitation yields and smaller particle sizes. In addition, the co-precipitation process at low temperature and high pressure led to the production of dry powders with higher concentrations of anthocyanins and total phenolic compounds.
JOURNAL OF CO2 UTILIZATION
(2022)
Article
Fisheries
Yaser Mohammadi, Barzan Bahrami Kamangar, Mohammad Ali Zarei
Summary: The study evaluated the effects of grape seed proanthocyanidin extract on growth performance, serum biochemical properties, fillet proximate composition, and liver antioxidant enzyme activity in common carp fingerlings. The results showed dose-dependent effects of GSPE on various parameters, with low levels showing positive impacts.
Article
Biochemistry & Molecular Biology
Kangliang Sheng, Jian Yang, Yifan Xu, Xiaowei Kong, Jingmin Wang, Yongzhong Wang
Summary: This study evaluated the effect of grape seed proanthocyanidin extract (GSPE) on aging and found that GSPE can improve antioxidant capacity and reduce inflammation levels. The study also discovered that GSPE administration can affect the gut microbiota composition and inhibit the NLRP3 inflammasome signaling pathway, providing a novel strategy for alleviating aging-induced alterations.
Article
Biochemistry & Molecular Biology
Yan Qi, Shilei Chen, Yukai Lu, Zihao Zhang, Song Wang, Naicheng Chen, Mingqiang Shen, Fang Chen, Mo Chen, Yong Quan, Lijing Yang, Yang Xu, Yongping Su, Mengjia Hu, Junping Wang
Summary: The research demonstrates that grape seed proanthocyanidin extract can ameliorate IR-induced HSPC injury by upregulating the expression of Foxo1 and its target antioxidant genes, thereby reducing ROS production and DNA damage while increasing HSC reconstituting ability and survival in irradiated mice.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Hanaa A. Hassan, Nermin E. El-Gharib
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2015)
Article
Urology & Nephrology
Hanaa A. Hassan, Gamal M. Edrees, Ezz M. El-Gamel, Elsamra A. El-Sayed
Article
Oncology
Hanaa Ali Hassan, Mohamed Labib Salem, Mona Samy Gouida, Khalid Mohammed El-Azab
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2018)
Review
Food Science & Technology
Tarun Belwal, Hari Prasad Devkota, Hanaa A. Hassan, Sudhir Ahluwalia, Mohamed Fawzy Ramadan, Andrei Mocan, Atanas G. Atanasov
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Hanaa A. Hassan, Hani S. Hafez, Mona S. Goda
Article
Biotechnology & Applied Microbiology
Hanaa A. Hassan, Azza M. El Wakf, Nermin E. El Gharib
Article
Biotechnology & Applied Microbiology
Hanaa A. Hassan, Wafaa M. El-Kholy, Samar E. Nour
Article
Biotechnology & Applied Microbiology
Azza M. El Wakf, Hanaa A. Hassan, Nermin S. Gharib
Article
Biotechnology & Applied Microbiology
Hanaa A. Hassan, Ahmed M. Isa, Wafaa M. El-Kholy, Samar E. Nour
Article
Biotechnology & Applied Microbiology
Hanaa A. Hassan, Gamal M. Edrees, Ezz M. El-Gamel, Elsamra A. El-sayed
Article
Biotechnology & Applied Microbiology
Azza M. El-Wakf, Hanaa A. Hassan, Ashraf Z. Mahmoud, Marwa N. Habza
Review
Food Science & Technology
H. A. Hassan, A. F. Abdel-Aziz
FOOD AND CHEMICAL TOXICOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Hanaa A. Hassan, Mosaad A. Abdel-Wahhab
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2012)
Article
Medicine, Research & Experimental
Hanaa A. Hassan, Hanaa M. Serag, Makwan S. Qadir, Mohamed Fawzy Ramadan
BIOMEDICINE & PHARMACOTHERAPY
(2017)