Modulation of 11β-Hydroxysteroid Dehydrogenase as a Strategy to Reduce Vascular Inflammation

Contribution of Endogenous Glucocorticoids and Their Intravascular Metabolism by 11β-HSDs to Postangioplasty Neointimal Proliferation in Mice

(2012) Javaid Iqbal et al.   ENDOCRINOLOGY

Mineralocorticoid receptor activation in myocardial infarction and failure: recent advances

(2012) Paolo Galuppo et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Auto-amplification of cortisol actions in human carotid atheroma is linked to arterial remodeling and stroke

(2012) Hanène Ayari et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease

(2012) F. Atalar et al.   GENETICS AND MOLECULAR RESEARCH

Regulation of cortisol bioavailability—effects on hormone measurement and action

(2012) Ilias Perogamvros et al.   Nature Reviews Endocrinology

Hypoxia-driven pathways in bone development, regeneration and disease

(2012) Christa Maes et al.   Nature Reviews Rheumatology

11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature

(2012) Mingjuan J. Luo et al.   PHYSIOLOGICAL GENOMICS

Painting blood vessels and atherosclerotic plaques with an adhesive drug depot

(2012) C. J. Kastrup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of In-Stent Stenosis by Oral Administration of Bindarit in Porcine Coronary Arteries

(2011) Armando Ialenti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adrenalectomy stimulates the formation of initial atherosclerotic lesions: Reversal by adrenal transplantation

(2011) Ronald J. van der Sluis et al.   ATHEROSCLEROSIS

Novel Fat Depot-Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11 -Hydroxysteroid Dehydrogenase Type 1-Deficient Mice

(2011) M. Wamil et al.   DIABETES

11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

(2011) Agnes E. Coutinho et al.   ENDOCRINOLOGY

Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice

(2011) Zoi Michailidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

The Hemostatic System as a Modulator of Atherosclerosis

(2011) Julian Ilcheff Borissoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11βHSD1-deficient mice post-MI

(2010) Sara J. McSweeney et al.   CARDIOVASCULAR RESEARCH

Adaptive T cell immune responses and atherogenesis

(2010) Soraya Taleb et al.   CURRENT OPINION IN PHARMACOLOGY

The 11- -Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

(2010) J. Rosenstock et al.   DIABETES CARE

11β-Hydroxysteroid Dehydrogenase Type 2 Deficiency Accelerates Atherogenesis and Causes Proinflammatory Changes in the Endothelium inApoe−/−Mice

(2010) Graeme A. Deuchar et al.   ENDOCRINOLOGY

11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress

(2010) Caitlin S. Wyrwoll et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

11 -Hydroxysteroid Dehydrogenase Type 1 Expression Is Increased in the Aged Mouse Hippocampus and Parietal Cortex and Causes Memory Impairments

(2010) M. C. Holmes et al.   JOURNAL OF NEUROSCIENCE

Biochemistry and physiology of hexose-6-phosphate knockout mice

(2010) Agnieszka E. Zielinska et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease

(2009) Patrick W.F. Hadoke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antidiabetic effects of 11β-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis

(2009) D. J. Lloyd et al.   DIABETES OBESITY & METABOLISM

Effect of Glucocorticoid Administration Early in Life on Aortic Prostaglandin Synthesis and Morphology in Atherosclerosis-Susceptible Pigeons

(2009) D. Deitemeyer et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Cortisol Inactivation by 11β-Hydroxysteroid dehydrogenase-2 May Enhance Endometrial Angiogenesis via Reduced Thrombospondin-1 in Heavy Menstruation

(2009) Mick Rae et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hypothalamic-Pituitary-Adrenal Axis Abnormalities in Response to Deletion of 11β-HSD1 is Strain-Dependent

(2009) R. N. Carter et al.   JOURNAL OF NEUROENDOCRINOLOGY

Innate and adaptive immunity in atherosclerosis

(2009) René R. S. Packard et al.   Seminars in Immunopathology

The role and regulation of 11β-hydroxysteroid dehydrogenase type 1 in the inflammatory response

(2008) Karen E. Chapman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

11β-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ and is stimulated by extracellular glucose

(2008) Anna A. Dzyakanchuk et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY