Hypoxia-driven pathways in bone development, regeneration and disease

Bevacizumab Inhibits Breast Cancer-Induced Osteolysis, Surrounding Soft Tissue Metastasis, and Angiogenesis in Rats as Visualized by VCT and MRI

(2015) Tobias Bäuerle et al.   NEOPLASIA

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Whole-exome sequencing detects somatic mutations of IDH1 in metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria (MC-HGA)

(2011) Lisenka E.L.M. Vissers et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche

(2011) M. Rehn et al.   BLOOD

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

IDH1 mutations are not found in cartilaginous tumours other than central and periosteal chondrosarcomas and enchondromas

(2011) Stephen Damato et al.   HISTOPATHOLOGY

VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival

(2011) Christa Maes et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

(2011) Elisa Araldi et al.   NATURE MEDICINE

Antiangiogenic therapy: impact on invasion, disease progression and metastasis

(2011) John M. L. Ebos et al.   Nature Reviews Clinical Oncology

A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis

(2011) Erinn B. Rankin et al.   Current Osteoporosis Reports

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches

(2010) I. G. Winkler et al.   BLOOD

Hypoxia, HIFs and bone development

(2010) Elisa Araldi et al.   BONE

Anti-Placental Growth Factor Reduces Bone Metastasis by Blocking Tumor Cell Engraftment and Osteoclast Differentiation

(2010) L. Coenegrachts et al.   CANCER RESEARCH

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

How does PKMζ maintain long-term memory?

(2010) Todd C. Sacktor   NATURE REVIEWS NEUROSCIENCE

Genetic Control of Bone Formation

(2009) Gerard Karsenty et al.   Annual Review of Cell and Developmental Biology

Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble flt-1

(2009) Tomoyuki Matsumoto et al.   ARTHRITIS AND RHEUMATISM

Extracellular matrix genes as hypoxia-inducible targets

(2009) Johanna Myllyharju et al.   CELL AND TISSUE RESEARCH

VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

(2009) Marja Lohela et al.   CURRENT OPINION IN CELL BIOLOGY

The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf

(2009) I. Eshkar-Oren et al.   DEVELOPMENT

The Role of Hypoxia in Development of the Mammalian Embryo

(2009) Sally L. Dunwoodie   DEVELOPMENTAL CELL

Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

(2009) Christa Maes et al.   EMBO JOURNAL

Role of the Osteoblast Lineage in the Bone Marrow Hematopoietic Niches

(2009) Joy Y Wu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

(2009) Ernestina Schipani et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypoxia-inducible factors 1α and 2α exert both distinct and overlapping functions in long bone development

(2009) Stacy H. Shomento et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Role of hypoxia-inducible factor-1α in angiogenic–osteogenic coupling

(2009) Ryan C. Riddle et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice

(2009) Xing Shen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment

(2009) Lauren K. Dunn et al.   PLoS One

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Bone Formation During Distraction Osteogenesis Is Dependent on Both VEGFR1 and VEGFR2 Signaling

(2008) Kimberly A Jacobsen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Detection of functional haematopoietic stem cell niche using real-time imaging

(2008) Yucai Xie et al.   NATURE

Activation of the hypoxia-inducible factor-1  pathway accelerates bone regeneration

(2008) C. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY

Bone remodeling during fracture repair: The cellular picture

(2008) Aaron Schindeler et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY