Article
Biochemistry & Molecular Biology
Zhengqing Hu, Li Tao, Meng Deng
Summary: The study found that Nestin and Sox2 double-expressing NSCs were observed in the AC area of mice from P3 to 4M in vivo, while the number of NSCs reduced significantly with age. In vitro, the neurosphere forming capability, cell proliferation, and percentage of Nestin and Sox2 double-expressing NSCs also decreased significantly with age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Jonas Engert, Bjoern Spahn, Linda Bieniussa, Rudolf Hagen, Kristen Rak, Johannes Voelker
Summary: This study aimed to investigate the neural stem cell potential of the medial geniculate body (MGB). The findings showed that MGB cells exhibited the cardinal features of neural stem cells, including self-renewal, formation of progenitor cells, and differentiation into all neuronal lineage cells. These findings contribute to a better understanding of the development of the auditory pathway.
Article
Cell Biology
Sara Mancinelli, Michela Vitiello, Maria Donnini, Francesca Mantile, Giuseppe Palma, Antonio Luciano, Claudio Arra, Laura Cerchia, Giovanna Lucia Liguori, Monica Fedele
Summary: The proper regulation of neurogenesis is crucial for brain development and function. Patz1 plays a key role in maintaining neural stem cells and progenitor cells (NS/PCs), with its absence leading to a reduction in NS/PC numbers and self-renewal capability. This highlights the importance of Patz1 in brain development and suggests potential implications for neurodegenerative disorders and glial brain tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tommy Nordstrom, Leif C. Andersson, Karl E. O. Akerman
Summary: The HCN channels play a crucial role in the proliferation and migration of embryonic neural progenitor cells (NPCs) and may trigger spontaneous electrical activity and chemotactic response in neurons.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Xiaojiang Liu, Yiqiu Cui, Jun Li, Cheng Guan, Shu Cai, Jinrong Ding, Jianhong Shen, Yixiang Guan
Summary: PTEN inhibitor bpv(pic) promotes the proliferation and differentiation of NSCs into neurons by regulating the expression and phosphorylation of the Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Jeng-Chang Chen, Wendy Yang, Li-Yun Tseng, Hsueh-Ling Chang
Summary: In this study, neurospheres were successfully generated using NSM and SRM, and they were able to assemble enteric neural networks in both two- and three-dimensional environments, as well as on gut explants. The transplantation of these neurospheres resulted in the reconstitution of myenteric plexuses in the recipient's rectum. This research provides valuable insights into the dynamic nature of the ENS and opens up possibilities for further exploration and understanding of its cellular activities.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Moawiah M. Naffaa, Rehan R. Khan, Chay T. Kuo, Henry H. Yin
Summary: This study identifies a neural circuit that regulates neurogenesis and cell proliferation in the lateral ventricle-subventricular zone. Glutamatergic projections from the anterior cingulate cortex and inhibitory projections from local interneurons modulate the activity of cholinergic neurons in the subependymal zone. Optogenetic stimulation and inhibition of this circuit can control neurogenesis in the ventral SVZ.
Article
Biochemistry & Molecular Biology
Rita Matta, Muhammad Sulaiman Yousafzai, Michael Murrell, Anjelica L. Gonzalez
Summary: The study found that microvascular endothelial cells play a crucial role in promoting neural stem cell clustering and migration, by affecting the expression of N-cadherin to promote cluster formation. This mechanism may enhance the therapeutic response of neural stem cells to sites of injury.
Review
Cell Biology
Emily A. B. Gilbert, Nishanth Lakshman, Kylie S. K. Lau, Cindi M. Morshead
Summary: Spinal cord injury affects millions of people worldwide, and there is currently no cure. Utilizing endogenous neural stem cells (NSCs) to replace lost cells and promote structural repair is a promising approach. However, there are still many unanswered questions regarding the heterogeneity of NSCs, their interaction with the environment, and factors that enhance their response.
Article
Materials Science, Biomaterials
Oliver G. Frost, Nazanin Owji, Richard Thorogate, Christos Kyriakidis, Prasad Sawadkar, Nicola Mordan, Jonathan C. Knowles, Ferdinand Lali, Elena Garcia-Gareta
Summary: Cell morphology plays a crucial role in cell-biomaterial surface interactions, indicating ideal candidates for various applications and reducing screening and development time.
BIOMATERIALS SCIENCE
(2021)
Article
Neurosciences
Dan Li, Yangnan Hu, Hao Wei, Wei Chen, Yun Liu, Xiaoqian Yan, Lingna Guo, Menghui Liao, Bo Chen, Renjie Chai, Mingliang Tang
Summary: SPIOs have good biocompatibility and adhesion, and can promote NSC proliferation in the presence of static magnetic field, which is of significant importance for tissue engineering and regenerative medicine.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hyung-Jin Won, Hyung-Sun Won, Jeong-Oh Shin
Summary: The mammalian palate plays a crucial role in feeding, respiration, and speech. Palatogenesis is a complex process involving cellular and molecular events. This study explores the role of miR-200c in palate development and suggests that miR-200c is essential in palatal fusion as it regulates E-cadherin expression, cell death, and cell migration. The findings provide insights into potential gene therapies for cleft palate.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Zhen Dong, Chunyi Li, Dawn Coates
Summary: The growing deer antler contains a stem cell niche that drives bone regeneration at a rapid rate. PTN is a highly expressed growth factor in the antler stem cell tissues, with potential interactions with receptors such as PTPRZ and ALK. In vitro studies show that PTN does not induce differentiation or proliferation in antler stem cells, but rather maintains their stem cell status.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemical Research Methods
James A. Carroll, Simote T. Foliaki, Cathryn L. Haigh
Summary: The study presents a novel method to model 3D mouse brain tissue using a 3D co-culture system with microglia, showing successful integration and functional response to external stimuli. The system offers a straightforward and effective way to study inter-cellular interactions and changes in any available mouse genotype within live tissue.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Neurosciences
Jonas Engert, Kristen Rak, Linda Bieniussa, Miriam Scholl, Rudolf Hagen, Johannes Voelker
Summary: This research project aimed to evaluate the neurogenic potential in the rat inferior colliculus from early postnatal days until adulthood, identifying and characterizing neural stem cells (NSCs) and their age-specific features. The study contributes to a better understanding of the development and plasticity of the auditory pathway, providing insights for potential therapeutic applications.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
