A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity

Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for Predictive Toxicology

(2011) Romualdo Benigni et al.   CHEMICAL REVIEWS

Measurement and Estimation of Electrophilic Reactivity for Predictive Toxicology

(2011) Johannes A. H. Schwöbel et al.   CHEMICAL REVIEWS

Assessment of Methods To Define the Applicability Domain of Structural Alert Models

(2011) C. M. Ellison et al.   Journal of Chemical Information and Modeling

Reactivity and aquatic toxicity of aromatic compounds transformable to quinone-type Michael acceptors

(2011) F. Bajot et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Mechanistic Category Formation for the Prediction of Respiratory Sensitization

(2010) S. J. Enoch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Reactivity assays: dealing with substances and samples in an in vitro world - the solution and the real problem

(2010) David W. Roberts et al.   CONTACT DERMATITIS

Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy

(2010) Anton C. de Groot et al.   CONTACT DERMATITIS

A review of the electrophilic reaction chemistry involved in covalent DNA binding

(2010) S. J. Enoch et al.   CRITICAL REVIEWS IN TOXICOLOGY

Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages

(2010) Shibashish Giri et al.   Expert Opinion on Drug Metabolism & Toxicology

Using In Silico Tools in a Weight of Evidence Approach to Aid Toxicological Assessment

(2010) Claire M. Ellison et al.   Molecular Informatics

Reactivity-based toxicity modelling of five-membered heterocyclic compounds: Application toTetrahymena pyriformis

(2010) T.W. Schultz et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Chemical reactivity measurements: Potential for characterization of respiratory chemical allergens

(2010) Jon F. Lalko et al.   TOXICOLOGY IN VITRO

Electrophilic Reaction Chemistry of Low Molecular Weight Respiratory Sensitizers

(2009) Steven J. Enoch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Chemical Mechanisms for Skin Sensitization by Aromatic Compounds with Hydroxy and Amino Groups

(2009) Aynur O. Aptula et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structural Alerts, Reactive Metabolites, and Protein Covalent Binding: How Reliable Are These Attributes as Predictors of Drug Toxicity?

(2009) Amit S. Kalgutkar et al.   CHEMISTRY & BIODIVERSITY

Formaldehyde-releasers: relationship to formaldehyde contact allergy. Contact allergy to formaldehyde and inventory of formaldehyde-releasers

(2009) Anton C de Groot et al.   CONTACT DERMATITIS

Read-across to rank skin sensitization potential: subcategories for the Michael acceptor domain

(2009) Terry Wayne Schultz et al.   CONTACT DERMATITIS

Skin sensitization and possible groupings for ‘read across’ for rosin based substances

(2009) H.P.A. Illing et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments

(2009) Shengde Wu et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Integrating (Q)SAR models, expert systems and read-across approaches for the prediction of developmental toxicity

(2009) M. Hewitt et al.   REPRODUCTIVE TOXICOLOGY

Using chemical categories to fill data gaps in hazard assessment

(2009) K. van Leeuwen et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Nucleophilic substitution reaction at an sp2 carbon of vinyl halides with an intramolecular thiol moiety: synthesis of thio-heterocycles

(2009) Mao-Yi Lei et al.   TETRAHEDRON

Formation of Structural Categories to Allow for Read-Across for Teratogenicity

(2009) Steven J. Enoch et al.   Quantitative structure-activity relationships & combinatorial science

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

(2008) R. Scott Obach et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Quantitative and Mechanistic Read Across for Predicting the Skin Sensitization Potential of Alkenes Acting via Michael Addition

(2008) Steven James Enoch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Repair of DNA damage induced by anthanthrene, a polycyclic aromatic hydrocarbon (PAH) without bay or fjord regions

(2008) Claus Desler et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Oximes: Metabolic Activation and Structure−Allergenic Activity Relationships

(2008) Moa Andresen Bergström et al.   JOURNAL OF MEDICINAL CHEMISTRY

REACH, non-testing approaches and the urgent need for a change in mind set

(2008) G. Schaafsma et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Category analysis of the substituted anilines studied in a 28-day repeat-dose toxicity test conducted on rats: Correlation between toxicity and chemical structure†

(2008) Y. Sakuratani et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach

(2008) S.J. Enoch et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Toxmatch–a new software tool to aid in the development and evaluation of chemically similar groups

(2008) G. Patlewicz et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

LC-MS–Based Characterization of the Peptide Reactivity of Chemicals to Improve the In Vitro Prediction of the Skin Sensitization Potential

(2008) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

Structure–Activity Relationships for Aldehyde Categories

(2007) John D. Walker et al.   Quantitative structure-activity relationships & combinatorial science