Bone remodeling in the context of cellular and systemic regulation: the role of osteocytes and the nervous system

In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism

(2015) N. Lara-Castillo et al.   BONE

Unlocking thesostgene

(2015) Mark L Johnson   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt Signaling

(2015) Philipp Leucht et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial

(2015) Benjamin Z Leder et al.   LANCET

Wnt inhibitory factor-1 functions as a tumor suppressor through modulating Wnt/β-catenin signaling in neuroblastoma

(2014) Jiao Zhang et al.   CANCER LETTERS

Wnt and the Wnt signaling pathway in bone development and disease

(2014) Yiping Wang   Frontiers in Bioscience-Landmark

Substance P Activates the Wnt Signal Transduction Pathway and Enhances the Differentiation of Mouse Preosteoblastic MC3T3-E1 Cells

(2014) Gang Mei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanical Load Increases in Bone Formation via a Sclerostin-Independent Pathway

(2014) Alyson Morse et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Neuropeptide Y Attenuates Stress-Induced Bone Loss Through Suppression of Noradrenaline Circuits

(2014) PA Baldock et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

(2014) Sofia Movérare-Skrtic et al.   NATURE MEDICINE

Romosozumab in Postmenopausal Women with Low Bone Mineral Density

(2014) Michael R. McClung et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Wnt Signaling and Sclerostin in the Pathogenesis of Glucocorticoid-Induced Osteoporosis

(2014) Núria Guañabens et al.   Current Osteoporosis Reports

Effect of glucocorticoid treatment on Wnt signalling antagonists (sclerostin and Dkk-1) and their relationship with bone turnover

(2013) L. Gifre et al.   BONE

Osteocytes: Master Orchestrators of Bone

(2013) Mitchell B. Schaffler et al.   CALCIFIED TISSUE INTERNATIONAL

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Osteoporosis Treatment and Prevention for Postmenopausal Women

(2013) JOANN V. PINKERTON et al.   CLINICAL OBSTETRICS AND GYNECOLOGY

The Osteocyte: An Endocrine Cell … and More

(2013) Sarah L. Dallas et al.   ENDOCRINE REVIEWS

Resorption Controls Bone Anabolism Driven by Parathyroid Hormone (PTH) Receptor Signaling in Osteocytes

(2013) Yumie Rhee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt3a Reestablishes Osteogenic Capacity to Bone Grafts from Aged Animals

(2013) Philipp Leucht et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Single- and Multiple-Dose Randomized Studies of Blosozumab, a Monoclonal Antibody Against Sclerostin, in Healthy Postmenopausal Women

(2013) Juliet McColm et al.   JOURNAL OF BONE AND MINERAL RESEARCH

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Neuropeptides stimulate human osteoblast activity and promote gap junctional intercellular communication

(2013) Wenhui Ma et al.   NEUROPEPTIDES

WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta

(2013) Christine M. Laine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling

(2013) Maarten van Dinther et al.   PLoS One

Preosteocytes/Osteocytes Have the Potential to Dedifferentiate Becoming a Source of Osteoblasts

(2013) Elena Torreggiani et al.   PLoS One

Characterization of Mesenchymal Progenitor Cell Populations Directly Derived from Human Dermis

(2013) Vaughan Feisst et al.   STEM CELLS AND DEVELOPMENT

Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury

(2012) Martine Roudier et al.   ARTHRITIS AND RHEUMATISM

Low-intensity pulsed ultrasound regulates proliferation and differentiation of osteoblasts through osteocytes

(2012) Lei Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An overview of the regulation of bone remodelling at the cellular level

(2012) Jasreen Kular et al.   CLINICAL BIOCHEMISTRY

Central Depletion of Brain-Derived Neurotrophic Factor in Mice Results in High Bone Mass and Metabolic Phenotype

(2012) C. Camerino et al.   ENDOCRINOLOGY

Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton

(2012) Melissa S. McNulty et al.   GENE EXPRESSION PATTERNS

Selective glucocorticoid receptor modulation maintains bone mineral density in mice

(2012) Sylvia Thiele et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Van Buchem disease: Clinical, biochemical, and densitometric features of patients and disease carriers

(2012) Antoon H van Lierop et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin

(2012) Aruna Kode et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteoblastogenesis regulation signals in bone remodeling

(2012) C. Zuo et al.   OSTEOPOROSIS INTERNATIONAL

Decreased osteoclastogenesis in serotonin-deficient mice

(2012) Y. Chabbi-Achengli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen and the skeleton

(2012) Sundeep Khosla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Osteocytes: central conductors of bone biology in normal and pathological conditions

(2011) A. Neve et al.   Acta Physiologica

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts

(2011) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury

(2011) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

(2011) B.Y. Chan et al.   OSTEOARTHRITIS AND CARTILAGE

Prostaglandin E2 Signals Through PTGER2 to Regulate Sclerostin Expression

(2011) Damian C. Genetos et al.   PLoS One

Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway

(2011) Asiri R. Wijenayaka et al.   PLoS One

Bone and bone marrow: The same organ

(2010) Andrea Del Fattore et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The two faces of serotonin in bone biology

(2010) Patricia Ducy et al.   JOURNAL OF CELL BIOLOGY

Hypothalamic regulation of bone

(2010) Frank Driessler et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Wnt Proteins Promote Bone Regeneration

(2010) S. Minear et al.   Science Translational Medicine

A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure

(2009) Vijay K. Yadav et al.   CELL

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

(2009) Chuwen Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin in Mineralized Matrices and van Buchem Disease

(2009) R.L. van Bezooijen et al.   JOURNAL OF DENTAL RESEARCH

Regulation of bone remodeling by the central and peripheral nervous system

(2008) Florent Elefteriou   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Functions of RANKL/RANK/OPG in bone modeling and remodeling

(2008) Brendan F. Boyce et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

Wdr5 Is Essential for Osteoblast Differentiation

(2008) Eric D. Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue

(2008) Luis Cardoso et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoclasts Control Osteoblast Chemotaxis via PDGF-BB/PDGF Receptor Beta Signaling

(2008) Maria Arantzazu Sanchez-Fernandez et al.   PLoS One