Article
Biochemistry & Molecular Biology
Magda C. Diaz-Vesga, Raul Flores-Vergara, Jaime A. Riquelme, Marcelo Llancaqueo, Gina Sanchez, Cecilia Vergara, Luis Michea, Paulina Donoso, Andrew F. G. Quest, Ivonne Olmedo, Zully Pedrozo
Summary: Cardiomyopathy is commonly observed in patients with ADPKD, even without renal dysfunction or high blood pressure. This study investigated the role of PC1 in cardiovascular pathophysiology and found that decreased PC1 expression in cardiomyocytes induces dilated cardiomyopathy through reduced BIN1 expression and T-tubule remodeling. These findings suggest a novel pathway that may contribute to the development of cardiomyopathy in ADPKD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Juan Ignacio Elio Mariangelo, Gabriel Dario Di Marzio, Luis Alberto Gonano, Matilde Said, Cecilia Mundina-Weilenmann
Summary: This study investigates the effects of hypertrophy and hypertension on cardiac alternans, finding that rats with hypertrophic myocardium are more prone to high-frequency mechanical and Ca2+ alternans. Subcellular Ca2+ alternans is also observed. It is suggested that tuning the refractoriness of SR Ca2+ release may prevent cardiac alternans in hypertrophic myocardium with adverse T-tubule remodeling.
Article
Physiology
Kanchan Kulkarni, Stavros Stavrakis, Khaled Elkholey, Jagmeet P. Singh, Kimberly A. Parks, Antonis A. Armoundas
Summary: Acute LLTS leads to a heart-rate dependent increase in TWA burden, while right atrial pacing significantly heightens TWA burden.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Junlan Zhou, Neha Singh, Chloe Monnier, William Marszalec, Li Gao, Jing Jin, Michael Frisk, William E. Louch, Suresh Verma, Prasanna Krishnamurthy, Elsa Nico, Maaz Mulla, Gary L. Aistrup, Raj Kishore, J. Andrew Wasserstrom
Summary: The study demonstrated that PIP2-mediated targeting of BIN1 to the sarcolemma may be compromised during heart failure development, leading to T-tubule remodeling. Additionally, the interaction between PIP2 and cardiac BIN1 is essential for T-tubule maintenance and function, with depletion of PIP2 potentially causing T-tubule disruption.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sean Yamakawa, Daniel Wu, Mona Dasgupta, Havisha Pedamallu, Binita Gupta, Rishi Modi, Maryam Mufti, Caitlin O'Callaghan, Michael Frisk, William E. Louch, Rishi Arora, Yohannes Shiferaw, Amy Burrell, Juliet Ryan, Lauren Nelson, Madeleine Chow, Sanjiv J. Shah, Gary Aistrup, Junlan Zhou, William Marszalec, J. Andrew Wasserstrom
Summary: T-tubule remodeling contributes significantly to abnormal Ca2+ cycling in failing hearts, reducing myocardial performance and increasing the incidence of triggered Ca2+ waves. The disruption of t-tubules alone plays a critical role in impaired Ca2+ cycling in heart failure.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Vrishti M. Phadumdeo, Brianna L. Mallare, Thomas J. Hund, Seth H. Weinberg
Summary: Using patient-specific data, the study investigates the influence of long-term changes in heart rate and electrical remodeling on the formation of proarrhythmic alternans in individuals with chronic heart failure. The results show that both the changes in heart rate and electrical remodeling have an impact on alternans formation, with variations in heart rate potentially playing a more influential role.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nikolay Naumenko, Maija Mutikainen, Lari Holappa, Jorge L. Ruas, Tomi Tuomainen, Pasi Tavi
Summary: Biological sex has a significant impact on the development of heart failure, with females being more susceptible. The transcriptional coactivator PGC-1 alpha plays a crucial role in regulating cardiac energy metabolism.
CARDIOVASCULAR RESEARCH
(2022)
Review
Cell Biology
Zoltan Husti, Andras Varro, Istvan Baczko
Summary: Chronic heart failure is associated with significant morbidity and mortality, often leading to cardiac arrhythmias such as ventricular tachyarrhythmias and atrial fibrillation. Changes in ion channel expression and function, as well as alterations in calcium handling in the heart, play a key role in arrhythmogenic remodeling. Understanding these mechanisms is crucial for improving arrhythmia management and preventing sudden cardiac death in heart failure patients.
Article
Pharmacology & Pharmacy
Prachi Umbarkar, Anand P. Singh, Sultan Tousif, Qinkun Zhang, Palaniappan Sethu, Hind Lal
Summary: Nintedanib (NTB) is an FDA-approved tyrosine kinase inhibitor for pulmonary fibrosis, and study shows its potential in reducing cardiac fibrosis and improving cardiac function in a murine heart failure model, suggesting its promising application in treating HF patients.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Thassio Mesquita, Rui Zhang, Jae Hyung Cho, Rui Zhang, Yen-Nien Lin, Lizbeth Sanchez, Joshua Goldhaber, Joseph K. Yu, Jialiu A. Liang, Weixin Liu, Natalia A. Trayanova, Eugenio Cingolani
Summary: Chronotropic incompetence and sinoatrial node (SAN) dysfunction are common problems in patients with heart failure, but the underlying mechanisms are not yet fully understood. This study identified intrinsic abnormalities in SAN structure and function as the cause of chronotropic incompetence in heart failure patients with preserved ejection fraction (HFpEF).
Review
Biochemistry & Molecular Biology
Xiaonan Sun, Jalen Alford, Hongyu Qiu
Summary: Mitochondrial remodeling is crucial for maintaining normal cellular function and dysregulation can lead to complex diseases. Understanding the molecular basis and regulatory network of mitochondrial remodeling is important for elucidating the pathogenesis of cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Health Care Sciences & Services
Barbara Ponikowska, Gracjan Iwanek, Agata Zdanowicz, Szymon Urban, Robert Zymlinski, Piotr Ponikowski, Jan Biegus
Summary: Heart failure is a major public concern with high incidence and prevalence, and the utility of various cardiovascular biomarkers in diagnosis and treatment is of significant importance, requiring further research.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
M. Scott Binder, Lisa R. Yanek, Wanjun Yang, Barbara Butcher, Sanaz Norgard, Joseph E. Marine, Aravindan Kolandaivelu, Jonathan Chrispin, Neal S. Fedarko, Hugh Calkins, Brian O'Rourke, Katherine C. Wu, Gordon F. Tomaselli, Andreas S. Barth
Summary: Heart failure (HF) is increasing in prevalence, and there is a need for better biomarkers to predict and prognosticate the condition. GDF-15 (growth differentiation factor-15) is a novel biomarker associated with HF mortality, but there have been no serial studies on GDF-15. This study investigated the association between GDF-15 levels over time and the occurrence of ventricular arrhythmias, HF hospitalizations, and all-cause mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Danilo Martins, Leonardo Rufino Garcia, Diego Aparecido Rios Queiroz, Taline Lazzarin, Carolina Rodrigues Tonon, Paola da Silva Balin, Bertha Furlan Polegato, Sergio Alberto Rupp de Paiva, Paula Schmidt Azevedo, Marcos Ferreira Minicucci, Leonardo Zornoff
Summary: Cardiac remodeling refers to a series of molecular, cellular, and interstitial changes in the heart that occur after different stimuli, manifesting clinically as changes in size, mass, geometry, and function. Remodeling plays a crucial pathophysiological role in the onset and progression of ventricular dysfunction. The role of oxidative stress as a therapeutic target for cardiac remodeling has been gaining attention in recent years.
Article
Cardiac & Cardiovascular Systems
Daniel Burkhoff, Veli K. Topkara, Gabriel Sayer, Nir Uriel
Summary: This review provides a comprehensive overview of research into LVAD therapy for heart failure, including the hemodynamic effects of LVAD support and the structural, cellular, and molecular aspects of LVAD-associated reverse remodeling. The review also discusses the synergistic effects of LVAD support with heart failure therapies on clinical outcomes and myocardial biology.
CIRCULATION RESEARCH
(2021)
Meeting Abstract
Biophysics
Christopher Y. Ko, Zhen Song, Zhilin Qu, James N. Weiss
BIOPHYSICAL JOURNAL
(2015)
Article
Biophysics
Zhen Song, Christopher Y. Ko, Michael Nivala, James N. Weiss, Zhilin Qu
BIOPHYSICAL JOURNAL
(2015)
Article
Cardiac & Cardiovascular Systems
Arash Pezhouman, Neha Singh, Zhen Song, Michael Nivala, Anahita Eskandari, Hong Cao, Aneesh Bapat, Christopher Y. Ko, Thao P. Nguyen, Zhilin Qu, Hrayr S. Karagueuzian, James N. Weiss
Meeting Abstract
Biophysics
Zhen Song, Richard Gordan, James N. Weiss, Lai-Hua Xie, Zhilin Qu
BIOPHYSICAL JOURNAL
(2016)
Meeting Abstract
Biophysics
Michael B. Liu, Christopher Y. Ko, Zhen Song, Alan Garfinkel, James N. Weiss, Qu Zhilin
BIOPHYSICAL JOURNAL
(2016)
Article
Biophysics
Michael B. Liu, Christopher Y. Ko, Zhen Song, Alan Garfinkel, James N. Weiss, Zhilin Qui
BIOPHYSICAL JOURNAL
(2016)
Article
Biochemical Research Methods
Zhen Song, Alain Karma, James N. Weiss, Zhilin Qu
PLOS COMPUTATIONAL BIOLOGY
(2016)
Article
Multidisciplinary Sciences
Zhen Song, Zhilin Qu, Alain Karma
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Cardiac & Cardiovascular Systems
Zhen Song, Michael B. Liu, Zhilin Qu
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2018)
Article
Biochemical Research Methods
Xiaodong Huang, Zhen Song, Zhilin Qui
PLOS COMPUTATIONAL BIOLOGY
(2018)
Article
Biophysics
Zhen Song, Lai-Hua Xie, James N. Weiss, Zhilin Qu
BIOPHYSICAL JOURNAL
(2019)
Article
Biophysics
Chunli Huang, Zhen Song, Julian Landaw, Zhilin Qu
BIOPHYSICAL JOURNAL
(2020)
Article
Biochemical Research Methods
Zhen Song, Zhilin Qu
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Biophysics
Zhaoyang Zhang, Michael B. Liu, Xiaodong Huang, Zhen Song, Zhilin Qu
Summary: QT prolongation is a major risk factor for lethal ventricular arrhythmias due to its association with early afterdepolarizations (EADs) and premature ventricular complexes (PVCs). This study found that PVCs can arise from two distinct mechanisms in ventricular action potential models: repolarization gradient (RG)-induced PVCs and phase-2 EAD-induced PVCs. RG-induced PVCs are promoted by increasing RG and L-type calcium current, while EAD-induced PVCs occur when the RG is small and are more sensitive to gap junction coupling. Further research is needed to better understand the links between these distinct PVC mechanisms and arrhythmogenesis in clinical settings.
BIOPHYSICAL JOURNAL
(2021)
Article
Biochemical Research Methods
Vikas Pandey, Lai-Hua Xie, Zhilin Qu, Zhen Song
Summary: Mitochondria play a critical role in influencing intracellular calcium dynamics, with their dysfunction being implicated in life-threatening cardiac arrhythmias. This study explores the mechanisms of Ca2+ alternans during mitochondrial depolarization, highlighting the role of ROS elevation and ATP reduction in promoting alternans acutely. Additionally, findings suggest that oxidized Ca2+/calmodulin-dependent protein kinase II activation may suppress Ca2+ alternans chronically. The study provides valuable insights for understanding the genesis of Ca2+ alternans in the context of mitochondrial depolarization.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)