Mitochondrial depolarization promotes calcium alternans: Mechanistic insights from a ventricular myocyte model

A spatiotemporal ventricular myocyte model incorporating mitochondrial calcium cycling

(2019) Zhen Song et al.   BIOPHYSICAL JOURNAL

Transverse tubular network structures in the genesis of intracellular calcium alternans and triggered activity in cardiac cells

(2018) Zhen Song et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Stochastic initiation and termination of calcium-mediated triggered activity in cardiac myocytes

(2017) Zhen Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of mitochondrial permeability transition pore (mPTP) in cardiac arrhythmias: Evidence from cyclophilin D knockout mice

(2016) Richard Gordan et al.   CELL CALCIUM

SERCA2a upregulation ameliorates cellular alternans induced by metabolic inhibition

(2016) Victoria Stary et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mitochondria-derived ROS bursts disturb Ca2+ cycling and induce abnormal automaticity in guinea pig cardiomyocytes: a theoretical study

(2015) Qince Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calcium-Voltage Coupling in the Genesis of Early and Delayed Afterdepolarizations in Cardiac Myocytes

(2015) Zhen Song et al.   BIOPHYSICAL JOURNAL

Mechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the Heart

(2015) Panagiota T. Foteinou et al.   BIOPHYSICAL JOURNAL

Molecular Basis of Hypokalemia-Induced Ventricular FibrillationCLINICAL PERSPECTIVE

(2015) Arash Pezhouman et al.   CIRCULATION

The growing importance of mitochondrial calcium in health and disease

(2015) Liron Boyman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Reports

Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity

(2015) Hirohito Shimizu et al.   eLife

Nonlinear and stochastic dynamics in the heart

(2014) Zhilin Qu et al.   PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS

Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca2+ Oscillations, Store-Operated Ca2+ Entry and Ca2+-Dependent Gene Expression in Response to Receptor Stimulation

(2014) Krishna Samanta et al.   PLoS One

Heart Failure and Mitochondrial Dysfunction

(2013) Anne A. Knowlton et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Mitochondrial calcium uptake

(2013) G. S. B. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium alternans in a couplon network model of ventricular myocytes: role of sarcoplasmic reticulum load

(2012) Michael Nivala et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Redox Regulation of Sodium and Calcium Handling

(2012) Stefan Wagner et al.   ANTIOXIDANTS & REDOX SIGNALING

Calcium alternans in cardiac myocytes: Order from disorder

(2012) Zhilin Qu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ca2+Regulation of Mitochondrial ATP Synthesis Visualized at the Single Cell Level

(2011) Masahiro Nakano et al.   ACS Chemical Biology

Linking Flickering to Waves and Whole-Cell Oscillations in a Mitochondrial Network Model

(2011) Melissa Nivala et al.   BIOPHYSICAL JOURNAL

Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress

(2011) Lufang Zhou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Mitochondrial Oscillations and Waves in Cardiac Myocytes: Insights from Computational Models

(2010) Ling Yang et al.   BIOPHYSICAL JOURNAL

A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network

(2010) Lufang Zhou et al.   PLoS Computational Biology

The Role of Mitochondria for the Regulation of Cardiac Alternans

(2010) Stela M. Florea et al.   Frontiers in Physiology

Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death

(2009) Andriy E. Belevych et al.   CARDIOVASCULAR RESEARCH

Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes

(2009) David Baddeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Ca Alternans: Coordinated Regulation by Sarcoplasmic Reticulum Release, Uptake, and Leak

(2008) Lai-Hua Xie et al.   BIOPHYSICAL JOURNAL

Mechanisms of calcium transient and action potential alternans in cardiac cells and tissues

(2007) William T. Clusin   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY