Review
Cell Biology
Xun Gao, Yuanyuan Xu
Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by progressive cognitive impairment and memory loss. Research indicates that endoplasmic reticulum stress and unfolded protein response play a role in the pathogenesis of AD. Targeting ER stress and ER stress-mediated apoptosis may be effective in treating AD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gehan Botrus, Richard M. Miller, Pedro Luiz Serrano Uson Jr, Geoffrey Kannan, Haiyong Han, Daniel D. Von Hoff
Summary: High levels of ER stress and UPR activation are present in pancreatic cancer, leading to adaptive mechanisms and potential apoptosis. This review discusses the mechanisms by which compounds activate the UPR pathways and induce apoptosis, and explores the potential of ER stress inducers for anti-tumor efficacy in pancreatic cancer. A new approach of increasing ER stress and UPR activation to incite apoptotic cell death in pancreatic cancer is hypothesized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sanaz Dastghaib, P. Sravan Kumar, Sajjad Aftabi, Gautam Damera, Azadeh Dalvand, Adel Sepanjnia, Mohammad Kiumarsi, Mohamad-Reza Aghanoori, Sukhwinder Singh Sohal, Sudharsana R. Ande, Javad Alizadeh, Pooneh Mokarram, Saeid Ghavami, Pawan Sharma, Amir A. Zeki
Summary: Lung cells are exposed to internal and external stressors, leading to disruption of protein homeostasis and activation of the UPR. Dysregulation of the UPR is associated with disease development and various human conditions. Compounds targeting the UPR pathway show potential for future therapeutic interventions.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Immunology
Wolfgang Vivas, Sebastian Weis
Summary: Pathogens and their toxic byproducts can cause tissue damage in infected hosts, triggering stress responses such as the unfolded protein response (UPR) to limit pathogenesis. However, prolonged or excessive activation of UPR may have detrimental effects including cell death.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Md. Sahab Uddin, Wing Shan Yu, Lee Wei Lim
Summary: Alzheimer's disease is characterized by the accumulation of misfolded proteins due to changes in protein homeostasis, possibly stemming from endoplasmic reticulum stress. The unfolded protein response is a critical signaling cascade that helps reduce misfolded proteins, but age-related changes in ER chaperones and enzymes can disrupt this process. The accumulation of misfolded proteins in AD, caused by sustained cellular stress, leads to neurodegeneration and neuronal death.
AGEING RESEARCH REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Adalberto Merighi, Laura Lossi
Summary: In addition to protein processing, the endoplasmic reticulum (ER) also plays roles in lipid synthesis, molecular transfers, and Ca2+ homeostasis. Proper protein folding and modification in the ER require molecular chaperones and a favorable environment. Disruption in ER conditions or chaperone capacity can lead to the unfolded protein response (UPR), triggering autophagy and potentially causing cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Noel Verjan Garcia, Kyung U. Hong, Nobuyuki Matoba
Summary: The endoplasmic reticulum (ER) plays a vital role in cell homeostasis and disruptions to its functions can lead to diseases. Dysregulated ER stress and UPR are linked to various human diseases, including inflammatory bowel disease (IBD). A recent study has shown that EPICERTIN can induce a protective UPR in colon epithelial cells, promoting mucosal healing in IBD models.
Review
Genetics & Heredity
Si Xu, Haihui Liu, Chen Wang, Yu Deng, Bin Xu, Tianyao Yang, Wei Liu
Summary: The unfolded protein response (UPR) is a cellular stress response mechanism that is induced by the accumulation of unfolded or misfolded proteins. It restores organelle homeostasis and promotes cell survival by increasing the expression of chaperone proteins, regulating protein quality control systems, and enhancing the protein degradation pathway. However, abnormal UPR can lead to cell death and is associated with neurodegenerative diseases.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Review
Pharmacology & Pharmacy
Bowen Qing, Song Wang, Yingan Du, Can Liu, Wei Li
Summary: Endoplasmic reticulum stress is a cell response to stress and its abnormal activation can influence tumor development and treatment efficacy. Investigating the molecular mechanism of ERS can help solve drug resistance in tumors and provide a novel strategy for treating refractory tumors.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Dan Qiao, Ziwei Zhang, Yali Zhang, Qian Chen, Yujun Chen, Yingjue Tang, Xiong Sun, Zhipeng Tang, Yancheng Dai
Summary: Ulcerative colitis is a chronic inflammatory disease, and endoplasmic reticular stress-induced autophagy plays a crucial role in its pathogenesis. Dysregulated autophagy can lead to inflammation and disruption of the intestinal barrier, increasing the risk of colonic diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinlong Tan, Yinju Liu, Fan Yang, Guohua Chen, Yongxiang Fang, Xiaobing He, Zhongzi Lou, Huaijie Jia, Zhizhong Jing, Weike Li
Summary: This study demonstrates that infection with lumpy skin disease virus (LSDV) causes endoplasmic reticulum (ER) stress and activates the unfolded protein response (UPR). It also shows that an unbalanced ER environment hampers LSDV replication and that PERK-eIF2a and IRE1-XBP1 signaling cascades contribute to LSDV replication.
Article
Cell Biology
Vittorio Abbonante, Alessandro Malara, Martina Chrisam, Samuele Metti, Paolo Soprano, Claudio Semplicini, Luca Bello, Valeria Bozzi, Monica Battiston, Alessandro Pecci, Elena Pegoraro, Luigi De Marco, Paola Braghetta, Paolo Bonaldo, Alessandra Balduini
Summary: Endoplasmic reticulum stress is linked to collagen retention, apoptosis, and impaired autophagy in megakaryocytes. This study highlights the interplay between genetic disorders of collagens, endoplasmic reticulum stress, and autophagy regulation in megakaryocytes.
Article
Fisheries
Guang-Xin Liu, Yu Tian, Chang-Hong Cheng, Hong-Ling Ma, Si-Gang Fan, Yi-Qin Deng, Juan Feng, Jian-Jun Jiang, Zhi-Xun Guo
Summary: In this study, a ATF6 gene from the mud crab (Sp-ATF6) was cloned and identified. Sp-ATF6 was widely expressed in different tissues and its expression was induced by hydrogen peroxide and V. parahaemolyticus challenge. Knocking down Sp-ATF6 reduced the expression of antioxidant-related genes and heat shock proteins after V. parahaemolyticus infection.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Microbiology
Yuki Ishiwata-Kimata, Yukio Kimata
Summary: This article reviews the canonical and up-to-date insights regarding yeast UPR, mainly focusing on the functions and regulation of Ire1 and HAC1.
Review
Plant Sciences
Sofia Reyes-Impellizzeri, Adrian A. Moreno
Summary: This review focuses on the impact of alterations in components of ERQC, ERAD, and UPR on plant responses to abiotic stresses. Evidence shows a clear connection between ERAD and UPR mechanisms, but the connection of ERQC components with these processes or their possible client proteins is lacking. Proteomics approaches are suggested to uncover the identity of these proteins and their connection to ER proteostasis.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Mina Thon, Toru Hosoi, Koichiro Ozawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Pharmacology & Pharmacy
Toru Hosoi, Toshiko Kohda, Syu Matsuzaki, Mizuho Ishiguchi, Ayaka Kuwamura, Tomoyuki Akita, Junko Tanaka, Koichiro Ozawa
BRITISH JOURNAL OF PHARMACOLOGY
(2016)
Article
Pharmacology & Pharmacy
Toru Hosoi, Mai Kakimoto, Keigo Tanaka, Jun Nomura, Koichiro Ozawa
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2016)
Article
Neurosciences
Toru Hosoi, Yosuke Yamawaki, Hitomi Kimura, Koichiro Ozawa
Article
Neurosciences
Toru Hosoi, Kanako Nakatsu, Akira Shimamoto, Hidetoshi Tahara, Koichiro Ozawa
NEUROSCIENCE LETTERS
(2016)
Review
Pharmacology & Pharmacy
Toru Hosoi, Koichiro Ozawa
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2016)
Article
Pharmacology & Pharmacy
Kayo Ikeda, Toru Hosoi, Michiko Yoshii, Masanori Sugiyama, Koichiro Ozawa
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2016)
Article
Pharmacology & Pharmacy
Toru Hosoi, Yuka Suyama, Takaaki Kayano, Koichiro Ozawa
FRONTIERS IN PHARMACOLOGY
(2016)
Review
Endocrinology & Metabolism
Toru Hosoi, Koichiro Ozawa
FRONTIERS IN ENDOCRINOLOGY
(2016)
Review
Endocrinology & Metabolism
Mina Thon, Toru Hosoi, Koichiro Ozawa
FRONTIERS IN ENDOCRINOLOGY
(2016)
Article
Pharmacology & Pharmacy
Kayo Ikeda, Mayu Kasuga, Toru Hosoi, Michiko Yoshii, Masanori Sugiyama, Aki Wako, Koichiro Ozawa
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2017)
Article
Endocrinology & Metabolism
Virginie Vauthier, Clara Roujeau, Patty Chen, Chamsy Sarkis, Stephanie Migrenne, Toru Hosoi, Koichiro Ozawa, Yves Rouille, Marc Foretz, Jacques Mallet, Jean-Marie Launay, Christophe Magnan, Ralf Jockers, Julie Dam
MOLECULAR METABOLISM
(2017)
Editorial Material
Endocrinology & Metabolism
Toru Hosoi, Margherita Maffei
FRONTIERS IN ENDOCRINOLOGY
(2017)
Article
Multidisciplinary Sciences
Mina Thon, Toru Hosoi, Koichiro Ozawa
SCIENTIFIC REPORTS
(2016)
Article
Pharmacology & Pharmacy
Mina Thon, Toru Hosoi, Chanbora Chea, Koichiro Ozawa
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2017)